Bee venom induces anti-tumor effects in HT-29 colon cancer cells through regulation of cell proliferation and apoptosis

Saghi, Hossein; Mirzavi, Farshad; Afshari, Amir R.; Jalili‐Nik, Mohammad; Mashkani, Baratali; Soukhtanloo, Mohammad

doi:10.1007/s11756-022-01201-9

Cited by 4 publications

(1 citation statement)

References 37 publications

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“…Melittin inhibited colon cancer cell growth via apoptosis induction and increased the expression of death receptors (4 and 5), p21, p53, and caspases (3, 8 and 9). The treatment further reduced NF-κB DNA binding activity, which validated its growth-inhibitory potential in colon cancer cells [ 39 ].…”

Section: Molecular Interaction Of Melittin (Honeybee Venom) In Cancermentioning

confidence: 99%

An Updated Review Summarizing the Anticancer Efficacy of Melittin from Bee Venom in Several Models of Human Cancers

Pandey

Khan

et al. 2023

Nutrients

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Apitherapy (using bee products) has gained broad recognition in cancer therapeutics globally. Honeybee venom has a broad range of biological potential, and its utilization is rapidly emerging in apitherapy. Bee products have significant potential to strengthen the immune system and improve human health. Thus, this review is targeted toward recapitulating the chemo-preventive potential of melittin (MEL), which constitutes a substantial portion of honeybee venom. Honeybee venom (apitoxin) is produced in the venom gland of the honeybee abdomen, and adult bees utilize it as a primary colony defense mechanism. Apitoxin comprises numerous biologically active compounds, including peptides, enzymes, amines, amino acids, phospholipids, minerals, carbohydrates, and volatile components. We are mainly focused on exploring the potential of melittin (a peptide component) of bee venom that has shown promising potential in the treatment of several human cancers, including breast, stomach, lung, prostate, ovary, kidney, colon, gastric, esophageal, cervical cancers, melanoma, osteosarcoma, and hepatocellular carcinoma. This review has summarized all potential studies related to the anticancerous efficacy of melittin (apitoxin), its formulations, conjugates, and nano-formulations against several human carcinomas, which would further pave the way for future researchers in developing potent drugs for cancer management.

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Section: Molecular Interaction Of Melittin (Honeybee Venom) In Cancermentioning

confidence: 99%

An Updated Review Summarizing the Anticancer Efficacy of Melittin from Bee Venom in Several Models of Human Cancers

Pandey

Khan

et al. 2023

Nutrients

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show abstract

The Cytotoxic Effects of Turkish Bee Venom (Apis mellifera) on Selected Cancer Cell Lines

Babayeva,

Dibek,

Kıvrak

et al. 2024

Int J Pept Res Ther

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The Anti-tumor, Anti-oxidative, and Anti-inflammatory Effects of Bee Venom in C26 Colon Carcinoma-Bearing Mice Model

Mirzavi,

Saghi,

Ebrahimi

et al. 2023

Iran J Sci

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Bee venom induces anti-tumor effects in HT-29 colon cancer cells through regulation of cell proliferation and apoptosis

Cited by 4 publications

References 37 publications

An Updated Review Summarizing the Anticancer Efficacy of Melittin from Bee Venom in Several Models of Human Cancers

An Updated Review Summarizing the Anticancer Efficacy of Melittin from Bee Venom in Several Models of Human Cancers

The Cytotoxic Effects of Turkish Bee Venom (Apis mellifera) on Selected Cancer Cell Lines

The Anti-tumor, Anti-oxidative, and Anti-inflammatory Effects of Bee Venom in C26 Colon Carcinoma-Bearing Mice Model

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