Bee Venom and Its Biological Effects

ABACI, Nurten; Orhan, İlkay Erdoğan

doi:10.38093/cupmap.1127949

Cited by 3 publications

(3 citation statements)

References 69 publications

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“…Melittin also inhibited the proliferation of leukemia cells by blocking calmodulin protein. It is reported to inhibit the TLR2, TLR4, CD14, NEMO, and PDGFR signaling pathways while activating the p38, ERK1/2, AKT, and PLC1 pathways, elevating calcium channel activation, activating death receptors (DR4, DR5), and indirectly stimulating the apoptosis-related caspase 3 and caspase 9 enzymes (Wehbe et al, 2019;Abaci, 2022).…”

Section: Bee Venommentioning

confidence: 99%

Revisiting edible insects as sources of therapeutics and drug delivery systems for cancer therapy

Sinha,

Choudhury

2024

Front. Pharmacol.

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Cancer has been medicine’s most formidable foe for long, and the rising incidence of the disease globally has made effective cancer therapy a significant challenge. Drug discovery is targeted at identifying efficacious compounds with minimal side effects and developments in nanotechnology and immunotherapy have shown promise in the fight against this complicated illness. Since ancient times, insects and insect-derived products have played a significant role in traditional medicine across several communities worldwide. The aim of this study was to inspect the traditional use of edible insects in various cultures and to explore their modern use in cancer therapy. Edible insects are sources of nutrients and a variety of beneficial substances with anticancer and immunomodulatory potential. Recently, insect derived bioactive-components have also been used as nanoparticles either in combination with chemotherapeutics or as a nano-cargo for the enhanced delivery of chemotherapeutic drugs due to their high biocompatibility, low bio-toxicity, and their antioxidant and anticancer effects. The crude extracts of different edible insects and their active components such as sericin, cecropin, solenopsin, melittin, antimicrobial peptides and fibroin produce anti-cancer and immunomodulatory effects by various mechanisms which have been discussed in this review.

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Section: Bee Venommentioning

confidence: 99%

Revisiting edible insects as sources of therapeutics and drug delivery systems for cancer therapy

Sinha,

Choudhury

2024

Front. Pharmacol.

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“…Honeybee venom (also known as apitoxin) is a complex biogenic mixture that is produced in the venom gland of honeybees and has several pharmaceutical and medical properties [87][88][89]. It is composed of water (88%) and various substances, including peptides and enzymes (such as esterase and protease), while melittin (one of the antimicrobial peptides) is the most effective and powerful agent [90][91][92].…”

Section: Bee Venommentioning

confidence: 99%

Bee Products for Poultry and Rabbits: Current Challenges and Perspectives

Abd El-Aziz,

Abo Ghanima,

Mota-Rojas

et al. 2023

Animals

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Poultry and rabbit production are important and rapidly growing agricultural subsectors, particularly in several developing countries. To ensure the sustainability of poultry and rabbit production, realistic poultry and rabbit farming practices must be improved. Apitherapy is a traditional alternative medicine that involves the prevention and treatment of some diseases with several bee products including propolis, royal jelly, pollen, and venom. More feeding investigations on the numerous benefits of bee products for poultry and rabbits are crucial to be addressed. Poultry and rabbit production has recently experienced numerous challenges, including climate change, disease spread, and antibiotic misuse. Improving animal welfare, health, and production is a top priority for all livestock farms, as is supplying consumers with safe and healthy products. Therefore, this review aims to collect and investigate recent relevant literature on the use of bee products, as feed additives, drinking water supplements, and injections, for poultry and rabbits to improve animal health and production. From the current findings, bee products can improve the growth and immunological performance of small-livestock animals, such as poultry and rabbits, by activating digestive enzymes, maintaining microbial balance, and promoting vitamin synthesis. Therefore, bee products could be a promising natural alternative to growth promoters, reproductive stimulants, and immunological enhancers in poultry and rabbit farms to provide safe and healthy products for humans.

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“…Bee sting therapy involves injecting BV into the skin via live bee stings. However, this treatment approach carries a signi cant risk of undesirable side effects [7].…”

Section: Introductionmentioning

confidence: 99%

Bradykinin Potentiating Factor from Egyptian Honey Bee Venom Fraction: A Potential Therapeutic Agent for Type 1 Diabetes

Habib,

Raheem,

El-Sabry

et al. 2023

Preprint

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Background: Natural products have gained attention as potential sources for drug leads, including in the management of diabetes and related complications. Honey bee venom (HBV) is a natural product known for its various biological activities, such as antihypertensive, analgesic, anti-inflammatory, and antioxidant effects. One specific fraction of HBV, called Bradykinin Potentiating Factor (BPF), has shown potential therapeutic effects. This study aimed to investigate the potential antidiabetic effect of BPF in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: An in vivo study was conducted on fifty albino male rats, which were divided into five groups: (GI) vehicle control animals, (GII) diabetic STZ-induced group, (GIII) nondiabetic BPF-treated group, (GIV) BPF-injected animals post-treated with STZ, and (GV) STZ-injected animals post-treated with BPF. The rats were fasted overnight before the experiment, and then their blood glucose levels were measured using a glucometer. The rats were then administered STZ to induce diabetes, except for the nondiabetic control group. The rats were treated with BPF at a dose of 0.1 mg/kg body weight for 15 days. After 15 days, the rats were euthanized, and their plasma glucose levels, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and C-reactive protein (C-RP) were evaluated and compared to STZ-treated diabetic rats and vehicle control rats. The histological and immunohistochemical analyses were carried out to predict the potential role of BPF in regulating metabolic and inflammatory variables associated with DM1. The mRNA expression of apelin and resistin genes was quantified using qRT-PCR, and the plasma protein profiles of C-RP and apelin were examined using sodium dodecyl sulphate-Polyacrylamide gel electrophoresis (SDS-PAGE) and western blotting techniques. Results: The data showed that STZ-induced DM1rats (GII) rats had significantly higher levels of plasma glucose, ALT, and AST than BPF-treated (GIII, GIV, GV) and nondiabetic control (GI) rats. The BPF-treated rats had significantly lower levels of plasma glucose, ALT, and AST than the STZ-treated rats. RT-qPCR revealed that the concentrations of apelin and resistin genes were significantly lower in BPF-treated (GIII, GIV, GV) and vehicle control (GI) groups than in STZ-treated (GII) rats. The concentrations of C-RP (28.3 kDa) and apelin (16 kDa) proteins were higher in STZ-treated (GII) rats than in BPF-STZ treated (GIV), STZ-BPF treated (GV), and negative control (GI) rats. BPF exhibited a significant reduction in the severity of these histological changes compared to the STZ-induced diabetic group (GII). The increase in GLUT4 expression by BPFtreatment may facilitate glucose uptake and utilization in liver tissue, leading to better glycemic control in diabetic rats. Conclusion: This study provides evidence for the therapeutic and protective effects of BPF against STZ-induced type 1 diabetes (DM1) complications in rats. The results indicated that BPF has antihyperglycemic and antioxidant effects, as demonstrated by improved biochemical parameters. BPF treatment was found to modulate the expression of apelin, resistin, C-RPproteins in the blood plasma, and GULT4 in the liver tissue of STZ-induced diabetic rats. The mechanisms underlying how BPF exerts its antihyperglycemic and antioxidant effects in DM1 were further examined. Conducting clinical trials and additional preclinical experiments will provide valuable insights into the viability of BPF as a therapeutic agent for diabetes treatment.

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Bee Venom and Its Biological Effects

Cited by 3 publications

References 69 publications

Revisiting edible insects as sources of therapeutics and drug delivery systems for cancer therapy

Revisiting edible insects as sources of therapeutics and drug delivery systems for cancer therapy

Bee Products for Poultry and Rabbits: Current Challenges and Perspectives

Bradykinin Potentiating Factor from Egyptian Honey Bee Venom Fraction: A Potential Therapeutic Agent for Type 1 Diabetes

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