Bee venom acupuncture for rheumatoid arthritis: a systematic review protocol

Lee, Ju Ah; Son, Mi Ju; Choi, Jiae; Yun, Kyung-Jin; Jun, Ji Hee; Lee, Myeong Soo

doi:10.1136/bmjopen-2013-004602

Cited by 18 publications

(11 citation statements)

References 16 publications

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“…Bee venom therapy (BVT) is the medicinal application of BV from honeybees into the human body for the treatment of some diseases, such as rheumatism arthritis [7]. This strategy has been used in alternative medicine for more than 5000 years.…”

Section: Generalities About Honeybeesmentioning

confidence: 99%

Bee Venom: Overview of Main Compounds and Bioactivities for Therapeutic Interests

et al. 2019

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Apitherapy is an alternate therapy that relies on the usage of honeybee products, most importantly bee venom for the treatment of many human diseases. The venom can be introduced into the human body by manual injection or by direct bee stings. Bee venom contains several active molecules such as peptides and enzymes that have advantageous potential in treating inflammation and central nervous system diseases, such as Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis. Moreover, bee venom has shown promising benefits against different types of cancer as well as anti-viral activity, even against the challenging human immunodeficiency virus (HIV). Many studies described biological activities of bee venom components and launched preclinical trials to improve the potential use of apitoxin and its constituents as the next generation of drugs. The aim of this review is to summarize the main compounds of bee venom, their primary biological properties, mechanisms of action, and their therapeutic values in alternative therapy strategies.

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Section: Generalities About Honeybeesmentioning

confidence: 99%

Bee Venom: Overview of Main Compounds and Bioactivities for Therapeutic Interests

et al. 2019

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“…However, the limited number, low quality, and small size of the RCTs make drawing conclusions difficult. [73][74][75] Summary-Although several studies described above have indicated a positive role for acupuncture in the treatment of rheumatoid arthritis, other studies have failed to show positive outcomes. [76][77][78][79] A survey study of 350 patients in rheumatology clinics with face-to-face structured interviews on self perceived efficacy of different types of complementary alternative medicine found that satisfaction was lowest among complementary medicine users with rheumatoid arthritis, vasculitis, or connective tissue diseases.…”

Section: Endogenous Factorsmentioning

confidence: 99%

Management of chronic pain using complementary and integrative medicine

Chen

Michalsen

2017

BMJ

149

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Complementary and integrative medicine (CIM) encompasses both Western-style medicine and complementary health approaches as a new combined approach to treat a variety of clinical conditions. Chronic pain is the leading indication for use of CIM, and about 33% of adults and 12% of children in the US have used it in this context. Although advances have been made in treatments for chronic pain, it remains inadequately controlled for many people. Adverse effects and complications of analgesic drugs, such as addiction, kidney failure, and gastrointestinal bleeding, also limit their use. CIM offers a multimodality treatment approach that can tackle the multidimensional nature of pain with fewer or no serious adverse effects. This review focuses on the use of CIM in three conditions with a high incidence of chronic pain: back pain, neck pain, and rheumatoid arthritis. It summarizes research on the mechanisms of action and clinical studies on the efficacy of commonly used CIM modalities such as acupuncture, mind-body system, dietary interventions and fasting, and herbal medicine and nutrients.

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“…The therapeutic applications of HBV include i.a. rheumatoid arthritis 21 , musculoskeletal pain 22 , neurodegenerative diseases (Parkinson’s disease, Alzheimer’s disease) 2 , 23 , skin diseases 24 , and neoplastic diseases 1 . Many in vitro and in vivo studies indicated that HBV has a direct antitumor effect and leads to inhibition of proliferation, metastasis, angiogenesis, and induction of apoptosis 1 , 25 .…”

Section: Introductionmentioning

confidence: 99%

Identification and quantification of honeybee venom constituents by multiplatform metabolomics

Klupczynska

Plewa

Dereziński

et al. 2020

Sci Rep

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Honeybee (Apis mellifera) venom (HBV) has been a subject of extensive proteomics research; however, scarce information on its metabolite composition can be found in the literature. The aim of the study was to identify and quantify the metabolites present in HBV. To gain the highest metabolite coverage, three different mass spectrometry (MS)-based methodologies were applied. In the first step, untargeted metabolomics was used, which employed high-resolution, accurate-mass Orbitrap MS. It allowed obtaining a broad overview of HBV metabolic components. Then, two targeted metabolomics approaches, which employed triple quadrupole MS, were applied to quantify metabolites in HBV samples. The untargeted metabolomics not only confirmed the presence of amines, amino acids, carbohydrates, and organic acids in HBV, but also provided information on venom components from other metabolite classes (e.g., nucleosides, alcohols, purine and pyrimidine derivatives). The combination of three MS-based metabolomics platforms facilitated the identification of 214 metabolites in HBV samples, among which 138 were quantified. The obtaining of the wide free amino acid profiles of HBV is one of the project’s achievements. Our study contributed significantly to broadening the knowledge about HBV composition and should be continued to obtain the most comprehensive metabolite profile of HBV.

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Bee venom acupuncture for rheumatoid arthritis: a systematic review protocol

Cited by 18 publications

References 16 publications

Bee Venom: Overview of Main Compounds and Bioactivities for Therapeutic Interests

Bee Venom: Overview of Main Compounds and Bioactivities for Therapeutic Interests

Management of chronic pain using complementary and integrative medicine

Identification and quantification of honeybee venom constituents by multiplatform metabolomics

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