Bee Stings and Chronic Pain Disorder

Steffen, Peter R. P.; Hofbauer, Hannes; Noll‐Hussong, Michael

doi:10.7759/cureus.2060

Cited by 1 publication

(1 citation statement)

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“…The potential adverse effects of bee venom therapy range from trivial skin reactions to life-threatening severe immunological responses [8]. Evidence-based studies concerning bee venom therapy in medical practice are still insufficient [9].…”

Section: Introductionmentioning

confidence: 99%

Assessment of bee venom therapy in animal model of statin-induced myopathy

Kader

Azmy

Maher

et al. 2019

Egypt J Neurol Psychiatry Neurosurg

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Background: Statin-induced myopathy is the most common adverse effect of statins. Bee venom provides a potential mean of controlling immune responses and inflammatory reactions; the proposed mechanisms for statininduced myopathy. Objective: The present study aimed at clarification of the role of the bee venom in prevention of statin-induced myopathy. Materials and methods: It was carried out on 30 Sprague-Dawley female rats. Rats were randomly classified into 3 groups: control group, statin group which received statins for 2 weeks, and venom group that was exposed to alternate day actual bee sting concurrent to statins administration for 2 weeks. Quantitative electromyography (QEMG) was performed as well as serum creatine kinase (CK) and cholesterol levels, in addition to in vitro muscle contractility tests. Results: QEMG and contractility tests showed significant changes in the statin group compared to both control and venom groups. Serum cholesterol level decreased with increase in CK levels in the statin and venom groups compared to controls; however, the CK level was significantly lower in the venom group as compared to the statin group. Conclusion: Bee venom therapy offers a simple and available means of prophylaxis against the myopathic effects induced by statins in animal model. However, it partly restricts the therapeutic effect of statins.

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Section: Introductionmentioning

confidence: 99%