Bee products and diabetes mellitus

Maroof, Kashif; Gan, Siew Hua

doi:10.1016/b978-0-323-85400-9.00012-5

Cited by 7 publications

(3 citation statements)

References 171 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[256] Therefore, depend- promoting the uptake of lipid in adipose tissue. [14,257] Apart from these remarkable therapeutic properties, intravenous administration of MLT trigger severe toxicity reactions associated with hemolysis.…”

Section: Conclusion and Future Trendsmentioning

confidence: 99%

See 1 more Smart Citation

Immunomodulatory activities and biomedical applications of melittin and its recent advances

Jafari,

Sadeghi,

Dehaghi

et al. 2024

Archiv der Pharmazie

View full text Add to dashboard Cite

Melittin (MLT), a peptide containing 26 amino acids, is a key constituent of bee venom. It comprises ∼40%–60% of the venom's dry weight and is the main pricing index for bee venom, being the causative factor of pain. The unique properties of MLT extracted from bee venom have made it a very valuable active ingredient in the pharmaceutical industry as this cationic and amphipathic peptide has propitious effects on human health in diverse biological processes. It has the ability to strongly impact the membranes of cells and display hemolytic activity with anticancer characteristics. However, the clinical application of MLT has been limited by its severe hemolytic activity, which poses a challenge for therapeutic use. By employing more efficient mechanisms, such as modifying the MLT sequence, genetic engineering, and nano‐delivery systems, it is anticipated that the limitations posed by MLT can be overcome, thereby enabling its wider application in therapeutic contexts. This review has outlined recent advancements in MLT's nano‐delivery systems and genetically engineered cells expressing MLT and provided an overview of where the MLTMLT's platforms are and where they will go in the future with the challenges ahead. The focus is on exploring how these approaches can overcome the limitations associated with MLT's hemolytic activity and improve its selectivity and efficacy in targeting cancer cells. These advancements hold promise for the creation of innovative and enhanced therapeutic approaches based on MLT for the treatment of cancer.

show abstract

Section: Conclusion and Future Trendsmentioning

confidence: 99%

“…It also exerts its hypolipidemic activity via promoting the uptake of lipid in adipose tissue. [ 14,257 ]…”

Section: Conclusion and Future Trendsmentioning

confidence: 99%

Immunomodulatory activities and biomedical applications of melittin and its recent advances

Jafari,

Sadeghi,

Dehaghi

et al. 2024

Archiv der Pharmazie

View full text Add to dashboard Cite

show abstract

“…7 Royal jelly is one of the most nutritious bee products and its constituents include water, protein, simple sugars (monosaccharides), omega fatty acids, minerals and vitamins. 8 Studies have shown the antiviral, 9 anti-inflammatory, insulin-like 10 and blood sugar-modulating 11 properties of royal jelly. According to the above-cited findings and arguments, the present study was conducted to investigate the effect of royal jelly capsules on blood pressure, laboratory parameters and critical course of Covid-19 in patients receiving corticosteroid therapy.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Tang Forte (Royal Jelly) Capsule on Hypoglycemia and Clinical Course in COVID-19 Patients Under Corticosteroid Therapy

Pourfard

Ahmadi

Habibi

et al. 2023

J Evid Based Complementary Altern Med

View full text Add to dashboard Cite

Corticosteroids improve the complications of Covid-19 but may cause some side effects such as hyperglycemia. Royal jelly is one of the bee products that exert anti-inflammatory, insulin-like, and hypoglycemic activities. The present study was conducted to investigate the effect of royal jelly capsules on blood sugar and the clinical course of Covid-19 in the patients receiving corticosteroid therapy. In this clinical trial, 72 Covid-19 patients with positive reverse transcription polymerase chain reaction (RT-PCR) test and pulmonary involvement hospitalized in Shahrekord Hajar Hospital were enrolled and randomized into two groups: treatment (receiving corticosteroids and Royal Jelly 1000 mg capsules daily for 7 days) and placebo (given corticosteroids and placebo). Laboratory tests, blood sugar, and clinical courses were determined and compared. Data was analyzed using SPSS version 16. On day 7 after the onset of the intervention, the dosage and frequency of insulin, FBS level, and required corticosteroid showed a decrease in both groups but the inter-group difference was not significant ( P > .05). As well, the Spo2 level indicated a non-significant increase and hospital stay length indicated a non-significant decrease in the intervention group ( P > .05). Among the symptoms, only headache, cough, and dyspnea indicated an improvement in the intervention group ( P < .05). Overall, the results indicated the short-term consumption of royal jelly could not significantly improve blood sugar and the clinical course of Covid-19; however, it could significantly improve headache, cough, and dyspnea in the patients.

show abstract

A preliminary study on phenolics, antioxidant and antibacterial activities of Acacia mangium and Garcinia mangostana propolis collected by Geniotrigona thoracica

Maroof¹,

Chen²,

Lee³

et al. 2023

Food Chemistry Advances

View full text Add to dashboard Cite

Bee products and diabetes mellitus

Cited by 7 publications

References 171 publications

Immunomodulatory activities and biomedical applications of melittin and its recent advances

Immunomodulatory activities and biomedical applications of melittin and its recent advances

The Effect of Tang Forte (Royal Jelly) Capsule on Hypoglycemia and Clinical Course in COVID-19 Patients Under Corticosteroid Therapy

A preliminary study on phenolics, antioxidant and antibacterial activities of Acacia mangium and Garcinia mangostana propolis collected by Geniotrigona thoracica

Contact Info

Product

Resources

About