Bee Pollen as a Promising Agent in the Burn Wounds Treatment

Olczyk, Paweł; Koprowski, Robert; Kaźmierczak, Justyna; Mencner, Łukasz; Wojtyczka, Robert D.; Stojko, Jerzy; Olczyk, Krystyna; Komosińska-Vassev, Katarzyna

doi:10.1155/2016/8473937

Cited by 16 publications

(10 citation statements)

References 30 publications

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“…However, the observed results generally confirm high anti-staphylococcal potential of BP and particularly BB extracts and additionally support the need for more advanced studies focusing on the application of these products for treatment of bacterial infections. Moreover, Olczyk and coworkers revealed that bee pollen ointment may affect the wound healing process of burn wounds, preventing infection of the newly formed tissue [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Bee Bread Exhibits Higher Antimicrobial Potential Compared to Bee Pollen

et al. 2021

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This study aimed at investigation of the antimicrobial potential of ethanolic extracts of bee bread (BB) and bee pollen (BP) and suspensions of these products in MHB (Mueller Hinton Broth). We covered 30 samples of BP and 19 samples of BB harvested in Polish apiaries. Slightly lower activity was observed against Gram-negative bacteria compared to Gram-positive staphylococci. BB extracts exhibited higher inhibitory potential with minimum inhibitory concentration (MIC) values in the range from 2.5 to 10% (v/v) against Staphylococcus aureus ATCC 25923 and ATCC 29213. Most active BB extracts, namely, BB6, BB11 and BB19, effectively inhibited growth of clinical isolates of S. aureus (n = 9), including MRSA (methicillin resistant Staphylococcus aureus) strains (n = 3) at concentrations ranging from 2.5 to 5.0% (v/v). Minimal bactericidal concentration (MBC) values were in the same range of concentrations; however, a shift from 2.5 to 5.0% (v/v) was observed for some products. The most active BP extracts inhibited the growth of reference strains of S. aureus at a concentration of 5% (v/v). Up to the concentration of 20% (v/v) three and seven BP extracts were not able to inhibit the growth of S. aureus ATCC 29213 and S. aureus ATCC 25923 respectively. The growth of staphylococci was also importantly inhibited in suspensions of the products in MHB. No correlation between phenolic content and antimicrobial activity was observed.

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Section: Discussionmentioning

confidence: 99%

Bee Bread Exhibits Higher Antimicrobial Potential Compared to Bee Pollen

et al. 2021

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“…Staphylococcus aureus) (Dustmann, 1979;Maeda et al, 2008) as well as anti-inflammatory (reviewed in Hadagali and Chua, 2014). Bee pollen has been described mostly as a nutraceutical, but has also been shown to exhibit pro-regenerative properties in burn wounds in pre-clinical experiments (Olczyk et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Exosome-like vesicles in Apis mellifera bee pollen, honey and royal jelly contribute to their antibacterial and pro-regenerative activity

Schuh

Aguayo

Zavala³

et al. 2019

Journal of Experimental Biology

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Microvesicles are key players in cellular communication. As glandular secretions present a rich source of active exosomes, we hypothesized that exosome-like vesicles are present in Apis mellifera hypopharyngeal gland secretomal products (honey, royal jelly and bee pollen), and participate in their known antibacterial and pro-regenerative effects. We developed an isolation protocol based on serial centrifugation and ultracentrifugation steps and demonstrated the presence of protein-containing exosome-like vesicles in all three bee-derived products. Assessing their antibacterial properties, we found that exosome-like vesicles had bacteriostatic, bactericidal and biofilm-inhibiting effects on Staphylococcus aureus. Furthermore, we demonstrated that mesenchymal stem cells (MSCs) internalize bee-derived exosomelike vesicles and that these vesicles influence the migration potential of the MSCs. In an in vitro wound-healing assay, honey and royal jelly exosome-like vesicles increased migration of human MSCs, demonstrating their inter-kingdom activity. In summary, we have discovered exosome-like vesicles as a new, active compound in bee pollen, honey and royal jelly.

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“…It also has a positive effect on the skin by reducing water loss and influencing the lipid barrier. Bee pollen is also used to treat skin burns due to the high content of biologically active substances [ 29 ].…”

Section: Products Of Bee Origin—effect On Human Health Its Various Applications and A Source Of Chemical Contaminantsmentioning

confidence: 99%

Effects of Insecticides and Microbiological Contaminants on Apis mellifera Health

Leska,

Nowak,

Nowak

et al. 2021

Molecules

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Over the past two decades, there has been an alarming decline in the number of honey bee colonies. This phenomenon is called Colony Collapse Disorder (CCD). Bee products play a significant role in human life and have a huge impact on agriculture, therefore bees are an economically important species. Honey has found its healing application in various sectors of human life, as well as other bee products such as royal jelly, propolis, and bee pollen. There are many putative factors of CCD, such as air pollution, GMO, viruses, or predators (such as wasps and hornets). It is, however, believed that pesticides and microorganisms play a huge role in the mass extinction of bee colonies. Insecticides are chemicals that are dangerous to both humans and the environment. They can cause enormous damage to bees’ nervous system and permanently weaken their immune system, making them vulnerable to other factors. Some of the insecticides that negatively affect bees are, for example, neonicotinoids, coumaphos, and chlorpyrifos. Microorganisms can cause various diseases in bees, weakening the health of the colony and often resulting in its extinction. Infection with microorganisms may result in the need to dispose of the entire hive to prevent the spread of pathogens to other hives. Many aspects of the impact of pesticides and microorganisms on bees are still unclear. The need to deepen knowledge in this matter is crucial, bearing in mind how important these animals are for human life.

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Bee Pollen as a Promising Agent in the Burn Wounds Treatment

Cited by 16 publications

References 30 publications

Bee Bread Exhibits Higher Antimicrobial Potential Compared to Bee Pollen

Bee Bread Exhibits Higher Antimicrobial Potential Compared to Bee Pollen

Exosome-like vesicles in Apis mellifera bee pollen, honey and royal jelly contribute to their antibacterial and pro-regenerative activity

Effects of Insecticides and Microbiological Contaminants on Apis mellifera Health

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