Bee Honey Added to the Oral Rehydration Solution in Treatment of Gastroenteritis in Infants and Children

Abdulrhman, Mamdouh; Mekawy, Mohamed; Awadalla, Maha; Mohamed, Alaa A.

doi:10.1089/jmf.2009.0075

Cited by 35 publications

(43 citation statements)

References 13 publications

(8 reference statements)

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“…This is in contrast with the results of Abdulrhman et al [16] who reported that addition of honey to ORS reduces the frequency of diarrhea in patients with gastroenteritis. Haffejee and Moosa [9] studied the effects of a honey-electrolyte solution (containing 50 ml of honey per liter, i.e.…”

Section: Discussioncontrasting

confidence: 99%

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Honey

Elnady¹,

Abdalmoneam²,

Aly³

et al. 2013

Medical Research Journal

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Background Diarrheal disease is one of the major causes of mortality of infants and toddlers in developing countries. Bee honey is a functional food that has a unique composition, antimicrobial properties, and bifidogenic and anti-inflammatory effects.Objective The present study was carried out to assess the effect of using pure honey as a form of adjuvant to oral rehydration solution (ORS) in the management of acute infantile diarrhea. Patients and methodsThe effect of floral honey on 150 infants aged 6-24 months suffering from acute diarrhea with mild to moderate dehydration was assessed. They were randomized into three groups of 50 infants each. Group I received WHO ORS only. The other two groups received floral honey in various forms: group II: received 50 ml honey in 1 l of ORS; group III: received pure honey at a dose of 5 ml every 6 h/day, in addition to ORS. The studied groups were observed for rehydration time, vomiting, diarrhea, and recovery time. Stool culture was carried out at admission. Stool pH and serum sodium and potassium levels were estimated and followed up until recovery. ResultsThe recovery time was significantly shorter in group III, which was treated with pure honey and ORS (3.1 ± 0.6 days) as compared with group I and group II (P < 0.05). Moreover, pure honey and ORS shortened the recovery time significantly both in infants with bacterial and in those with nonbacterial diarrhea. A significant positive correlation was found between the degree of dehydration and frequency of diarrhea (r = 0.340, P < 0.01). The recovery time was significantly negatively correlated with the frequency of diarrhea and stool pH (r = -0.340, P < 0.05).Conclusion Honey is a nonallergic, natural agent of high nutrient value. Pure honey administered as a form of adjuvant therapy in addition to ORS in cases of acute infantile diarrhea causes significant shortening of the recovery period, decreases the frequency of passing loose stools, and improves stool consistency. Further studies on pure honey as an adjuvant therapy in infantile diarrhea are recommended on a large scale.

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Section: Discussioncontrasting

confidence: 99%

“…This group included patients who received ORS with honey at a dose of 50 ml dissolved in 1 l of ORS, which resulted in a significant increase in the glucose content (109 mmol/l instead of 75 mmol/l) and osmolarity of ORS (310 mOsmol/l instead of 245 mOsmol/l), [16].…”

Section: Group IImentioning

confidence: 99%

Honey

Elnady¹,

Abdalmoneam²,

Aly³

et al. 2013

Medical Research Journal

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“…A clinical study by Abdulrahman, 2010, has reported the treatment of infantile gastroenteritis using honey. The study found that replacing the glucose in standard electrolyte oral rehydration solution (ORS) with honey reduced the recovery time of patients with gastroenteritis because the high sugar content in honey boosts electrolyte and water reabsorption in the gut [70]. …”

Section: Health Benefits Of Honeymentioning

confidence: 99%

Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits

Rao

Sammugam

Ramesh

et al. 2017

Oxidative Medicine and Cellular Longevity

619

471

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Background There are several health benefits that honeybee products such as honey, propolis, and royal jelly claim toward various types of diseases in addition to being food. Scope and Approach In this paper, the effects of honey, propolis, and royal jelly on different metabolic diseases, cancers, and other diseases have been reviewed. The modes of actions of these products have also been illustrated for purposes of better understanding. Key Findings and Conclusions An overview of honey, propolis, and royal jelly and their biological potentials was highlighted. The potential health benefits of honey, such as microbial inhibition, wound healing, and its effects on other diseases, are described. Propolis has been reported to have various health benefits related to gastrointestinal disorders, allergies, and gynecological, oral, and dermatological problems. Royal jelly is well known for its protective effects on reproductive health, neurodegenerative disorders, wound healing, and aging. Nevertheless, the exact mechanisms of action of honey, propolis, and royal jelly on the abovementioned diseases and activities have not been not fully elucidated, and further research is warranted to explain their exact contributions.

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“…8,9 Short-term top-ups of accessible Zn stores are effective in maintaining improved Zn status over a period of several weeks. [12][13][14] The efficacy of low-osmolarity ORS, 15 rice-based ORS formulations, 16,17 and ORS containing novel compounds 18,19 have some beneficial effects on children with diarrhea. In 2004, the World Health Organisation and the United Nations Children's Fund first recommended the use of low-osmolarity ORS and supplementation with Zn for up to 2 weeks as part of the management of acute diarrhea.…”

Section: Introductionmentioning

confidence: 99%

Zinc-Fortified Oral Rehydration Solution Improved Intestinal Permeability and Small Intestinal Mucosal Recovery

Tran

Hawkes

Graham

et al. 2014

Clin Pediatr (Phila)

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A randomized double-blind placebo-controlled study was conducted in children admitted to hospital with gastroenteritis (≥3 loose stools per day). All were treated for 5 days following admission with either zinc (Zn, 3 mg) or without Zn-fortified rice-based oral rehydration solution (ORS). (13)C-sucrose breath test (SBT) and intestinal permeability (lactulose/rhamnose or L/R ratio) were performed concurrently prior to commencement of ORS with or without Zn and at day 5 post-admission. There was a significant improvement in the SBT results in both the Zn-fortified group, median (5th-95th percentile) 2.1% (0.4% to 8.3%) versus 4.4% (0.4% to 10.4%), P < .05, and control group, 1.4% (0.1% to 5.4%) versus 4.3% (0.4% to 11.4%), P < .05, between the day of admission and day 5 post-admission. In the Zn-fortified group, there was also a significant improvement in L/R ratio between the day of admission and day 5 post-admission, 53.0 (19.5-90.6) versus 17.7 (13.4-83.2), P < .05. Low levels of Zn improved intestinal permeability but did not enhance short-term recovery following diarrheal illness.

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Bee Honey Added to the Oral Rehydration Solution in Treatment of Gastroenteritis in Infants and Children

Cited by 35 publications

References 13 publications

Honey

Honey

Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits

Zinc-Fortified Oral Rehydration Solution Improved Intestinal Permeability and Small Intestinal Mucosal Recovery

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