Bee bread attenuates high fat diet induced renal pathology in obese rats via modulation of oxidative stress, downregulation of NF-kB mediated inflammation and Bax signalling

Eleazu, Chinedum; Suleiman, Joseph Bagi; Othman, Zaidatul Akmal; Zakaria, Zaida; Nna, Victor Udo; Hussain, Nik Hazlina Nik; Mohamed, Mahaneem

doi:10.1080/13813455.2020.1752258

Cited by 26 publications

(47 citation statements)

References 61 publications

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“…Previous studies by our group (Eleazu et al, 2020;Othman et al, 2020) revealed that apigenin, caffeic acid, ferulic acid, isorhamnetin, and kaempferol were the polyphenolic compounds that were detected in the bee bread we investigated while vitamins A and E, thiamine, riboflavin, and Zn were the nutrients with antiobesity potentials in it.…”

Section: Sod Dismutates the Superoxide Radical (O −mentioning

confidence: 96%

“…The H 2 O 2 generated from the action of SOD is broken down to H 2 O and O 2 by the action of GPx (Eleazu et al, 2020).…”

Section: Sod Dismutates the Superoxide Radical (O −mentioning

confidence: 99%

“…One major problem with the increasing prevalence of obesity is its associated comorbidities including: insulin resistance, hyperglycemia, dyslipidemia (Teasdale et al., 2013; Tomlinson et al., 2016), and hypertension, all of which have been implicated in the development of metabolic syndrome (a group of conditions that aggravate the risk of heart disease, stroke, and diabetes; Eleazu et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Oxidative stress refers to an imbalance between the antioxidants and reactive oxygen and nitrogen species (RONS) in a system in favor of these reactive species (Eleazu et al, 2020;Huang et al, 2015). It also reflects the negative impact the lack of balance between the prooxidant and antioxidant defense mechanisms of a system has on cells (Poloczek et al, 2020).…”

mentioning

confidence: 99%

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Effect of bee bread on some biochemical parameters and skeletal muscle histology of high‐fat diet‐induced obese Sprague‐Dawley rats

et al. 2021

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Obesity is a disorder of body weight regulatory systems that is characterized by an accumulation of excess body fat due to hyperplasia and hypertrophy of adipocytes (Eleazu et al., 2019; Ferrier, 2014). Several factors have been implicated in the etiology of obesity including genetic and environmental factors, stress, disequilibrium in energy intake and expenditure, increased energy from gut/intestinal

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Section: Sod Dismutates the Superoxide Radical (O −mentioning

confidence: 96%

“…The H 2 O 2 generated from the action of SOD is broken down to H 2 O and O 2 by the action of GPx (Eleazu et al, 2020).…”

Section: Sod Dismutates the Superoxide Radical (O −mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Effect of bee bread on some biochemical parameters and skeletal muscle histology of high‐fat diet‐induced obese Sprague‐Dawley rats

et al. 2021

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“…In another research, Eleazu et al [ 118 ] studied bee bread effects on obesity-induced renal pathology. The outcomes showed 0.5 g/kg H. itama bee bread attenuated renal pathology caused by obesity by diminishing oxidative stress and downregulating the expressions of inflammatory markers and bax-mediated proapoptotic condition in the kidney of HFD obese rats.…”

Section: Health Benefitsmentioning

confidence: 99%

Stingless Bee-Collected Pollen (Bee Bread): Chemical and Microbiology Properties and Health Benefits

2021

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Stingless bee-collected pollen (bee bread) is a mixture of bee pollen, bee salivary enzymes, and regurgitated honey, fermented by indigenous microbes during storage in the cerumen pot. Current literature data for bee bread is overshadowed by bee pollen, particularly of honeybee Apis. In regions such as South America, Australia, and Southeast Asia, information on stingless bee bee bread is mainly sought to promote the meliponiculture industry for socioeconomic development. This review aims to highlight the physicochemical properties and health benefits of bee bread from the stingless bee. In addition, it describes the current progress on identification of beneficial microbes associated with bee bread and its relation to the bee gut. This review provides the basis for promoting research on stingless bee bee bread, its nutrients, and microbes for application in the food and pharmaceutical industries.

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Tabersonine attenuates obesity‐induced renal injury via inhibiting NF‐κB‐mediated inflammation

Qian

Wang

Lin

et al. 2023

Phytotherapy Research

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Obesity-induced metabolic disorders can cause chronic inflammation in the whole body, activating the nuclear factor kappa B (NF-κB) pathway and inducing apoptosis.Therefore, anti-inflammatory strategies may be effective in preventing obesityrelated renal injury. Tabersonine (Tab) has been used pharmacologically to alleviate inflammation-related symptoms. This study evaluated the therapeutic effect of Tab on obesity-related renal injury and explored the pharmacological mechanism. Tab (20 mg/kg) relieved HFD-induced renal structural disorder and alleviated renal functional decline in mice, including improvement of renal tissue fibrosis, reducing renal cell apoptosis and inflammation in renal tissues. Mechanistically, we demonstrated that Tab inhibited the activation of NF-κB signaling pathway both in vivo and in vitro, thereby improving the renal tissue lesions in the mice with obesity-related renal injury. In both the obese mouse model and the mouse glomerular mesangial cell model, the natural compound Tab ameliorated HFD-and saturated fatty acid-induced renal cell injury by inhibiting the activation of NF-κB signaling pathway. Our data suggest that Tab may become a potential candidate for the prevention and treatment of obesity-related renal injury.

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Bee bread attenuates high fat diet induced renal pathology in obese rats via modulation of oxidative stress, downregulation of NF-kB mediated inflammation and Bax signalling

Cited by 26 publications

References 61 publications

Effect of bee bread on some biochemical parameters and skeletal muscle histology of high‐fat diet‐induced obese Sprague‐Dawley rats

Effect of bee bread on some biochemical parameters and skeletal muscle histology of high‐fat diet‐induced obese Sprague‐Dawley rats

Stingless Bee-Collected Pollen (Bee Bread): Chemical and Microbiology Properties and Health Benefits

Tabersonine attenuates obesity‐induced renal injury via inhibiting NF‐κB‐mediated inflammation

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