Bedside hyperspectral imaging indicates a microcirculatory sepsis pattern - an observational study

Hyperspectral imaging for perioperative monitoring of microcirculatory tissue oxygenation and tissue water content in pancreatic surgery — an observational clinical pilot study

“…Future studies should therefore examine the relationship between HSI monitoring data and the function of different organ systems during haemodynamic compromise to answer whether skin HSI indicates coherent microcirculatory impairment of multiple organ systems. Our group previously showed that palm and fingertip HSI evaluation in sepsis patients revealed a distinctive pattern of reduced skin oxygenation and perfusion quality in combination with microcirculatory blood pooling and increased tissue water content (Dietrich et al, 2021 ). Although we did not observe a correlation with perioperative organ dysfunction in patients with major abdominal surgery, the results of this study add new aspects regarding bedside HSI as microcirculatory monitoring device.…”

“…An important research question is whether skin HSI monitoring data reflect concomitant systemic or organ-specific microcirculatory compromise and/or organ dysfunction. Recent data on skin HSI monitoring in septic patients points to an association with organ dysfunction (Kazune et al, 2019a ; Kazune et al, 2019b ; Dietrich et al, 2021 ). Surgical data showed that relevant intraoperative changes in organ oxygenation and perfusion quality can be identified by HSI monitoring (Jansen-Winkeln et al, 2018 ; Kohler et al, 2019 ; Thiem et al, 2021 ).…”

“…We proposed that an elevated THI might reflect pronounced alteration of skin microcirculation indicative for disturbed perfusion and a stagnant flow situation in septic patients. Furthermore, palm and fingertip THI discriminated between non-survivors and survivors and was predictive for 28-day survival in sepsis patients (Dietrich et al, 2021 ). In the present study, postoperative THI values discriminated between patients with higher and lower blood loss.…”

“…In septic patients, a significantly increased palm and fingertip TWI could be observed compared to healthy controls. Palm TWI during sepsis was persistently increased and correlated positively with the SOFA score on the third day following ICU admission (Dietrich et al, 2021 ). These results point to the potential of perioperative bedside HSI monitoring to detect increased skin water content and provide real-time stop signs to avoid fluid overload and tissue oedema.…”

Establishment and validation of a logistic regression model for prediction of septic shock severity in children

“…Sepsis is an acute organ dysfunction that is secondary to infection [ 1 ]. It is a major cause of death in patients with complex conditions including humoral and cellular reactions, inflammatory and anti-inflammatory issues, and circulatory problems [ 2 – 4 ]. The most severe complication of sepsis, septic shock, has a mortality of 20–35% [ 5 ].…”