Bedside diagnostic testing of body fluids

Peredy, Tamas R.; Powers, Robert D.

doi:10.1016/s0735-6757(97)90137-6

Cited by 15 publications

(4 citation statements)

References 60 publications

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“…Nonetheless, the timeframes to complete these tests are often still not consistent with the POC [109,110]. For example, a typical doctor's visit that lasts 15–30 min does not permit for a diagnostic test that requires more than 1hr to complete.…”

Section: Towards Point-of-carementioning

confidence: 99%

Porous Bead-Based Diagnostic Platforms: Bridging the Gaps in Healthcare

Chou

Wong

Christodoulides

et al. 2012

Sensors

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Advances in lab-on-a-chip systems have strong potential for multiplexed detection of a wide range of analytes with reduced sample and reagent volume; lower costs and shorter analysis times. The completion of high-fidelity multiplexed and multiclass assays remains a challenge for the medical microdevice field; as it struggles to achieve and expand upon at the point-of-care the quality of results that are achieved now routinely in remote laboratory settings. This review article serves to explore for the first time the key intersection of multiplexed bead-based detection systems with integrated microfluidic structures alongside porous capture elements together with biomarker validation studies. These strategically important elements are evaluated here in the context of platform generation as suitable for near-patient testing. Essential issues related to the scalability of these modular sensor ensembles are explored as are attempts to move such multiplexed and multiclass platforms into large-scale clinical trials. Recent efforts in these bead sensors have shown advantages over planar microarrays in terms of their capacity to generate multiplexed test results with shorter analysis times. Through high surface-to-volume ratios and encoding capabilities; porous bead-based ensembles; when combined with microfluidic elements; allow for high-throughput testing for enzymatic assays; general chemistries; protein; antibody and oligonucleotide applications.

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Section: Towards Point-of-carementioning

confidence: 99%

Porous Bead-Based Diagnostic Platforms: Bridging the Gaps in Healthcare

Chou

Wong

Christodoulides

et al. 2012

Sensors

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“…Urine, saliva, sweat, interstitial fluid, breath and tears are possible sampling sources (Brady et al, 2006). Urine testing is a well established method typically implemented as a point of care solution wherein a dipstick containing a reagent changes colour depending on the concentration of a target species (Peredy and Powers, 1997). More recently, saliva has been identified as a "mirror of the body" for diagnostic testing (Lee et al, 2009, Kaufman E, 2002.…”

Section: Wearable Chemical Sensors "Looking In" To Monitor Heathmentioning

confidence: 99%

“…Urine testing is a well established method, typically implemented as a point of care solution wherein a dipstick that contains a reagent changes colour depending on the concentration of a target species (Peredy & Powers, 1997).…”

Section: Wearable Chemical Sensors "Lookingmentioning

confidence: 99%

Fibers and Fabrics for Chemical and Biological Sensing

Coyle

Benito‐Lopez²,

Radu³

et al. 2010

Research Journal of Textile and Apparel

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Wearable sensors can be used to monitor many interesting parameters about the wearer's physiology and environment, with important applications in personal health and well-being, sports performance and personal safety. Wearable chemical sensors can monitor the status of the wearer by accessing body fluids, such as sweat, in an unobtrusive manner. They can also be used to protect the wearer from hazards in the environment by sampling potentially harmful gas emissions such as carbon monoxide. Integrating chemical sensors into textile structures is a challenging and complex task. Issues which must be considered include sample collection, calibration, waste handling, fouling and reliability. Sensors must also be durable and comfortable to wear. Here we present examples of wearable chemical sensors that monitor the person and also their environment. We also discuss the issues involved in developing wearable chemical sensors and strategies for sensor design and textile integration.

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“…The advantages of high-throughput multiplex testing through high surface-to-volume ratios of solid support porous spheres have allowed for shorter analysis times consistent with the POC [13,14] using low sample and reagent requirements. Further, the p-BNC assay characteristics now in development adhere to the guidelines for POC tests that have been developed and designated with the acronym COMMAND QUALS [9], that is Cheap, Obvious, Miniaturized, Multiplexed, Automated, Nonperishable, Dependable, Quick, Unobtrusive, Adaptable, Limited (volume), and Self-contained.…”

mentioning

confidence: 99%