Bedeutung der Familienanamnese beim Zervixkarzinom

Fischer, Uta; Raptis, Georgios; Lc, Horn

doi:10.1055/s-2001-14791

Cited by 2 publications

(2 citation statements)

References 29 publications

(40 reference statements)

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“…Almost one third of the patients had at least one first‐degree relative with cancer at any site, which should be compared with the results from another study of patients with cervical cancer where only 15–20% of the cases had at least one first‐degree relative with malignancies at any site ( 46 ) .…”

Section: Discussionmentioning

confidence: 99%

Primary carcinoma of the vagina: factors influencing the age at diagnosis. The Radiumhemmet series 1956-96

Hellman¹,

Silfverswärd²,

Nilsson³

et al. 2004

Int J Gynecol Cancer

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The objective to this retrospective study of 341 cases of primary carcinoma of vagina (PCV) diagnosed between 1956 and 1996 was to find whether epidemiological, clinical, and histopathological variables were related to the age at diagnosis of patients with PCV. The univariate statistical analysis showed that younger age at diagnosis significantly correlated with a history of cervical dysplasia, hysterectomy, gynecological infections, and tumors located in the upper part of the vagina, whereas older age at diagnosis significantly correlated with late menarche and exophytically growing tumors. In the multivariate regression analysis, the remaining independent predictors were a history of cervical dysplasia and age at menarche. Further, parity >/=4 as well as nulliparity, smoking, and unstable marital status were more common among patients with PCV than among those in the general Swedish female population. This study indicates that the etiology of vaginal carcinoma may be age related. In young patients, the disease seems to be etiologically related to cervical neoplasia and thus human papillomavirus (HPV) dependent. However, in the most common age group, the older patients, there might be another (probably non-HPV-related) etiology associated with hormonal factors and trauma to the vagina.

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Section: Discussionmentioning

confidence: 99%

Primary carcinoma of the vagina: factors influencing the age at diagnosis. The Radiumhemmet series 1956-96

Hellman¹,

Silfverswärd²,

Nilsson³

et al. 2004

Int J Gynecol Cancer

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show abstract

“…Reported figures on familial cervical cancer in situ (CIS) and cervical cancer are summarized in Table 1. Apart from three studies (the study by Brinton et al [18], who investigated the family history of women with cervical cancer in a North American population, the study by Fischer et al [19] in a German population and Furgyik et al [20] in a Swedish population), all other available studies used the Swedish national cancer registers. Not surprisingly the results of the Swedish studies are similar, although different methods to investigate familial risks were used and results were expressed in different types of risk units [12-14,21,22].…”

Section: Review and Discussionmentioning

confidence: 99%

Familial Cervical Cancer: Case Reports, Review and Clinical Implications

Zoodsma

Sijmons

Vries

et al. 2004

Hered Cancer Clin Pract

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We report three Dutch families with familial clustering of (pre)neoplastic cervical disease, review the literature on familial risks of cervical intraepithelial neoplasia (CIN) and cervical cancer, and discuss possible practical guidelines for women with a family history of cervical cancer. Daughters and sisters of women with cervical cancer have been reported to have a relative risk of 1.5-2.3 to develop this type of cancer. From a practical clinical point of view, we suggest that as in women with an increased non-genetic risk to develop cervical cancer (e.g. because of immunosuppressive therapy) increased surveillance to detect this tumour should be considered in women with an increased risk based on family history. Cessation of smoking should be advised. As the use of condoms at least prevents HPV re-infection its use can be recommended as a way to lower the cervical cancer risk. Future studies to determine the genetic contribution to the development of cervical cancer should include the paternal family history of cancer and, because genetic predisposition might express itself as a higher risk to develop precursors of cervical cancer, carcinoma in situ and CIN grade II-III.

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Bedeutung der Familienanamnese beim Zervixkarzinom

Cited by 2 publications

References 29 publications

Primary carcinoma of the vagina: factors influencing the age at diagnosis. The Radiumhemmet series 1956-96

Primary carcinoma of the vagina: factors influencing the age at diagnosis. The Radiumhemmet series 1956-96

Familial Cervical Cancer: Case Reports, Review and Clinical Implications

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