Beclomethasone Dipropionate Aerosol Effect on the Adrenals in Normal Persons

Mygind, Niels; Hansen, Ib

doi:10.1111/j.1398-9995.1973.tb01327.x

Cited by 31 publications

(10 citation statements)

References 11 publications

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“…Multiple studies carried out in approximately 20,00 subjects and summarized previously have shown that these preparations cause few systemic side-effects provided that the dose is kept low [1,2]. The few systemic side-effects demonstrated are more marked in children [3][4][5][6][7][8]. In the case of inhaled beclomethasone in adults, the threshold dose is close to 1 mg daily.…”

mentioning

confidence: 99%

Skin bruising in asthmatic subjects treated with high doses of inhaled steroids: frequency and association with adrenal function

Roy¹,

LeBlanc²,

Paquette³

et al. 1996

Eur Respir J

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High doses of inhaled corticosteroids (ICS) (budesonide and beclomethasone ≥800 µg·day -1 ) are commonly used in the treatment of asthma. Some investigators have presented evidence for cutaneous effects (bruising), which suggests systemic absorption. This study aimed to assess the prevalence of skin bruising, relate the occurrence of skin bruising to adrenocortical function, and determine the risk factors for skin bruising.One hundred adult asthmatic subjects taking high doses (800-2,000 µg·day -1 ) of ICS for 3 months or more were recruited in an asthma clinic, and 100 control subjects paired for sex and age were recruited from an ophthalmology out-patient clinic. A detailed questionnaire on asthma, general habits and cutaneous lesions was administered. A cutaneous examination was performed. Urine cortisol levels were assessed on two consecutive days. Blood cortisol level and the response to Cortrosyn injection (60 min test) were evaluated.One hundred adult asthmatics (66 females and 34 males), 73 on beclomethasone and 27 on budesonide, were included. The prevalence of skin bruising was 71% based on the questionnaire (32% in controls) and 48% (39 out of 81 subjects) based on direct examination of the skin. We found a satisfactory association between the response to questionnaire and examination of the skin. Adrenocortical function testing showed that a minority of subjects (14 with at least one abnormal test) had lower urinary or blood cortisol levels. These low cortisol levels occurred in subjects who reported skin bruising. By multiple logistic regression, being a female (odds ratio (OR)=20; 95% confidence interval (95% CI)=13-33) and taking ICS for asthma (OR=12; 95% CI=8-18) were significantly (t=5.4) related to the likelihood of developing skin bruising. In addition, among the asthmatic subjects, being older (OR=1.6; 95% CI=1.1-2.4/10 yrs interval) (t=2.3) and being a female (OR=22; 95% CI=7-75) (t=5.0) influenced the occurrence of skin bruising as documented by questionnaire.In asthmatic subjects, taking high doses of ICS is associated with: 1) increased occurrence of skin bruising by comparison with controls, particularly in older subjects; and 2) a generally normal adrenocortical function, although this function is significantly lower in subjects reporting skin bruising.

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confidence: 99%

Skin bruising in asthmatic subjects treated with high doses of inhaled steroids: frequency and association with adrenal function

Roy¹,

LeBlanc²,

Paquette³

et al. 1996

Eur Respir J

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“…These results also confirm the lack of adrenal suppression following admin¬ istration of BDP in most patients, as shown by other workers. 1,2,9 We conclude that BDP is a satisfac¬ tory alternative to systemic glucocorticosteroids in patients with chronic bronchial asthma, suffering from systemic complications and ad¬ renal insufficiency caused by steroid therapy, and represents a valuable addition to the therapeutic arsenal of bronchial asthma.…”

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confidence: 88%

Beclomethasone Dipropionate Use in Chronic Asthmatic Patients

Bondarevsky¹

1976

JAMA

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“…Inhaled beclomethasone dipropionate is beneficial in the treatment of bronchial asthma in doses that do not affect adrenal function (i, 2,4,7,9,12,13,16). It is also effective in patients with hay fever in an intranasal dose of 400 ng/day without producing evident adrenal suppression; this is according to Mygind (15), who registered a lower, but not significantly lower, mean value of 17-ketogenic steroids in urine during the beclomethasone treatment period than in the period of placebo treatment.…”

Section: Discussionmentioning

confidence: 99%

An Open Assessment of Becotide® (Beclomethasone Dipropionate) Nasal Spray in Seasonal Allergic Rhinitis

Löfkvist

Svensson

1975

Allergy

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The treatment of allergic diseases in the respiratory tract sometimes also includes cortisone therapy. A local application of cortisone on the shock organ should imply a reasonable possibility of preventing the systemic side-effects often observed in connection with prolonged peroral or parenteral steroid treatment. With this in view, cortisone, hydrocortisone, prednisolone, and dexamethasone-among other drugs-have been tried (3,5,6,8,17, 18,19,20,21,22), but all of them have proved to have an insufficient effect in doses without systemic resorption. There was renewed interest in the local application mode of treatment with the introduction of beclomethasone dipropionate and betamethasone valerate. In reports on the treatment of bronchial asthma by Brown et al. (i), and of allergic rhinitis by Mygind (15), the good therapeutic effect of beclomethasone dipropionate has been brought out. The preparation has been evaluated as a high-grade, locally active gluco-corticoid which is effective without any considerable side-effects. On the basis of prior investigations, we did not find the recommendations of dosage established. It is desirable to aim at still lower dosage while maintaining the effect of a drug. In the present report, results are given of trials with beclomethasone dipropionate against hay fever in lower dosage than in earlier investigations.

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Beclomethasone Dipropionate Aerosol Effect on the Adrenals in Normal Persons

Cited by 31 publications

References 11 publications

Skin bruising in asthmatic subjects treated with high doses of inhaled steroids: frequency and association with adrenal function

Skin bruising in asthmatic subjects treated with high doses of inhaled steroids: frequency and association with adrenal function

Beclomethasone Dipropionate Use in Chronic Asthmatic Patients

An Open Assessment of Becotide® (Beclomethasone Dipropionate) Nasal Spray in Seasonal Allergic Rhinitis

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