Beauvericin and enniatins H, I and MK1688 are new potent inhibitors of human immunodeficiency virus type-1 integrase

Shin, Cha‐Gyun; An, Dog-Gn; Song, Hwayoung; Lee, Chan

doi:10.1038/ja.2009.102

Cited by 52 publications

(34 citation statements)

References 19 publications

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“…Beauvericin is a mycotoxin produced by many fungi, including Fusarium spp ( Wang & Xu 2012 ). Beauvericin displays insecticidal ( Hamill et al 1969 ), antitumour ( Cheng et al 2009 ), antibacterial, antifungal and antiviral activities ( Zhan et al 2007 , Shin et al 2009 , Meca et al 2010 , Xu et al 2010 ). Beauvericin was also reported to have leishmanicidal activity (EC 50 1.86 μM) against promastigotes of Leishmania braziliensis ( Nascimento et al 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Bioactive endophytic fungi isolated from Caesalpinia echinata Lam. (Brazilwood) and identification of beauvericin as a trypanocidal metabolite from Fusarium sp.

Campos

Sales

Romanha

et al. 2015

Mem. Inst. Oswaldo Cruz

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Aiming to identify new sources of bioactive secondary metabolites, we isolated 82 endophytic fungi from stems and barks of the native Brazilian tree Caesalpinia echinata Lam. (Fabaceae). We tested their ethyl acetate extracts in several in vitro assays. The organic extracts from three isolates showed antibacterial activity against Staphylococcus aureus and Escherichia coli [minimal inhibitory concentration (MIC) 32-64 μg/mL]. One isolate inhibited the growth of Salmonella typhimurium (MIC 64 μg/mL) and two isolates inhibited the growth of Klebsiella oxytoca (MIC 64 μg/mL), Candida albicans and Candida tropicalis (MIC 64-128 μg/mL). Fourteen extracts at a concentration of 20 μg/mL showed antitumour activities against human breast cancer and human renal cancer cells, while two isolates showed anti-tumour activities against human melanoma cancer cells. Six extracts were able to reduce the proliferation of human peripheral blood mononuclear cells, indicating some degree of selective toxicity. Four isolates were able to inhibit Leishmania (Leishmania) amazonensis and one isolate inhibited Trypanosoma cruzi by at least 40% at 20 μg/mL. The trypanocidal extract obtained from Fusarium sp. [KF611679] culture was subjected to bioguided fractionation, which revealed beauvericin as the compound responsible for the observed toxicity of Fusarium sp. to T. cruzi. This depsipeptide showed a half maximal inhibitory concentration of 1.9 μg/mL (2.43 μM) in a T. cruzi cellular culture assay.

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Section: Discussionmentioning

confidence: 99%

Bioactive endophytic fungi isolated from Caesalpinia echinata Lam. (Brazilwood) and identification of beauvericin as a trypanocidal metabolite from Fusarium sp.

Campos

Sales

Romanha

et al. 2015

Mem. Inst. Oswaldo Cruz

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“…Shin et al (2009) proposed beauvericin as the most effective inhibitor of cyclic hexadepsipeptides that inhibit HIV-1 integrase. However, an effective focus on the antiviral potential of beauvericin is required for the exploration of its activity against the more fatal and epidemic disease-causing viruses, such as HBV, SARS, H1N1, and AIV .…”

Section: Antiviral Activitymentioning

confidence: 99%

Beauveria bassiana: Biocontrol Beyond Lepidopteran Pests

et al. 2015

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“…Furthermore, enniatins, especially enniatins A, A 1 , B, and B 1 , possess anticarcinogenic properties by induction of apoptosis and disruption of ERK signaling (Dornetshuber et al, 2007;Lee et al, 2008;Hyun et al, 2009;Wätjen et al, 2009). Interestingly, it has been shown that enniatins possess anti-HIV activity, whereby a mixture of enniatins B, B 1 , and A exhibit the highest activity compared to all other enniatins isolated so far (Firáková et al, 2007;Shin et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Optimization of Enniatin Production by Solid-Phase Fermentation of Fusarium tricinctum

Wang

Debbab

Hemphill

et al. 2013

Zeitschrift Für Naturforschung C

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Enniatins are cyclic depsipeptides produced by fungi of the genus Fusarium that are of interest due to their pronounced biological activities; especially enniatins A, A 1 , B, and B 1 possess anticarcinogenic and anti-HIV properties. In the present study, F. tricinctum was grown on seven solid media and in one liquid growth medium with or without addition of peptone or of amino acid precursors in order to identify favourable media with simple cultivation conditions for maximum enniatin production. Additionally, the optimal duration of growth was investigated for the highest yields of enniatins. From the different media analysed, white beans (Phaseolus vulgaris, solid medium) induced the highest accumulation of enniatins A, A 1 , B, and B 1 , that reached a maximum of 1,365 mg total enniatins in 1 L growth medium after 18 days of fermentation. Fermentation of F. tricinctum on white beans gave the highest yield of enniatins compared to all other media analysed in this study.

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Beauvericin and enniatins H, I and MK1688 are new potent inhibitors of human immunodeficiency virus type-1 integrase

Cited by 52 publications

References 19 publications

Bioactive endophytic fungi isolated from Caesalpinia echinata Lam. (Brazilwood) and identification of beauvericin as a trypanocidal metabolite from Fusarium sp.

Bioactive endophytic fungi isolated from Caesalpinia echinata Lam. (Brazilwood) and identification of beauvericin as a trypanocidal metabolite from Fusarium sp.

Beauveria bassiana: Biocontrol Beyond Lepidopteran Pests

Optimization of Enniatin Production by Solid-Phase Fermentation of Fusarium tricinctum

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