Beauty from within: Oral administration of a sulfur-containing supplement methylsulfonylmethane improves signs of skin ageing

Abstract

Abstract. Background: Methylsulfonylmethane (MSM) is an organosulfur compound with known benefits for joint health, sports nutrition, immune function, and anti‐aging formulations and is gaining popularity as a nutritional supplement for the support of hair, skin and nails. Methods: The study was conducted in two steps; in Part I (pilot study) a panel of 20 participants ingested either 3 g a day of MSM or placebo capsules for 16 weeks. Visual and subject self assessment of wrinkles and skin texture as the predominant sign of ageing was observed. In Part II (dose-response study), 63 participants ingested either 1 g or 3 g per day of MSM for 16 weeks. Expert clinical grading, instrumental measurements and consumer perception was used to evaluate skin conditions like lines and wrinkles. Additionally, instrumentational analysis was conducted using corneometer and cutometer for investigation of skin hydration, firmness and elasticity. Results: Part I of the study clearly indicates that oral ingestion of MSM (3 g/d) reduces signs of ageing like facial wrinkles ( p < 0.05) and skin roughness ( p < 0.05) as compared to placebo. Detailed analysis in Part II instrumentation assessments showed a significant ( p < 0.05) improvement from baseline in the severity of facial wrinkles, as well as improved skin firmness, elasticity and hydration with MSM. Some of these parameters exhibited a good dose-response indicating that the higher (3 g/d) of the supplement was more effective than the lower dose of 1 g/d, but generally the lower dose of 1 g/d appeared to be sufficiently effective in reducing the facial signs of ageing. Conclusion: This study indicated that MSM is effective in reducing visual signs of skin ageing even at a low dose of 1 g/d.

Non-invasive biomechanical assessment of the prolapsed vaginal wall – an explorative pilot study on cutometry and indentometry

“…In vivo cutometry and indentometry have been widely applied to the facial skin, mainly for the evaluation of cosmetic treatments (12)(13)(14)(15)(16). Compared to reported Cutometer parameters of the skin, our study suggests that the vaginal wall is less rm (i.e.…”

“…Cutometry and indentometry are two widely applied methods for non-invasive evaluation of biomechanical properties of soft tissues (11). Both methods have mainly been applied to the skin within the eld of dermatology and cosmetology (12)(13)(14)(15)(16). Cutometry is a suction-based method that has been applied to the vaginal wall before (17,18).…”

Mutation or not, what directly establishes a neoplastic state, namely cellular immortality and autonomy, still remains unknown and should be prioritized in our research

“…Neural differentiation of the PC12 rat pheochromocytoma cell line induced by nerve growth factors or some chemicals is among the best-studied examples [537][538][539]. A dietary supplement methylsulfonylmethane [540], which is also a normal oxidation product of dimethyl sulfoxide (DMSO) [541], can obviate metastatic properties of a few different cancer cell lines via differentiating the cells [542][543][544][545][546]. Actually, there have been some clinical successes as proof in the remission of acute promyelocytic leukemias via differentiation induced by treatment with retinoic acid [547] or arsenic trioxide [548,549], alone or in combination with other chemotherapeutic agents, although relapses from extant cells often ensue later [107].…”

Beauty from within: A Review of the Science behind Yuliv<sup>TM</sup> Collagen Drink: An Anti-Aging Nutraceutical

“…Oral nutraceuticals and dietary supplements to counteract the progressive decline in the amount and function of collagen and related dermal structures have gained interest over the last years [2] [3]. Those nutraceuticals include collagen peptides, vitamins, minerals, and antioxidants and have the intend to slow down the natural aging process [29] [30].…”