There has been significant recent progress in our understanding of human mate choice. We outline several frontiers of rapid cultural change which may increasingly directly affect individual self-evaluation in the mating market, formation and maintenance of long-term partnerships, and potentially reproductive outcome and child health. Specifically, we review evidence for the effects of (1) increasing exposure to mass media, (2) the advent of novel ways to meet potential partners, and (3) cultural influences which may disrupt or alter the expression of evolved mate preferences. We comment on the potential for these effects to influence self-perception and partner-perception, with downstream effects on relationship satisfaction and stability. A common theme emerges, which is that these effects may contribute to relationship dissatisfaction and dissolution, with negative implications for societal change. We then address how we envisage evolutionary psychology research may focus on and offer informed approaches to ameliorate these effects in the future. We picture the development of a field of applied evolutionary psychology, and we suggest that this will increasingly become a central focus for many researchers.