‘Beauty and the beast’ in infection: How immune–endocrine interactions regulate systemic metabolism in the context of infection

Wensveen, Felix M.; Šestan, Marko; Wensveen, Tamara Turk; Polić, Bojan

doi:10.1002/eji.201847895

Cited by 29 publications

(27 citation statements)

References 165 publications

(219 reference statements)

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“…The random transcriptional inactivation of X chromosomes in females may also help offset certain mutation-related dysregulation of the immune system ( 13 ). Differences in endocrine system regulation in females compared to males significantly affect disease processes including respiratory, cardiovascular, and renal disease ( 6 , 14 – 18 ). As nations across the world navigate their way through the Coronavirus disease 2019 (COVID-19) pandemic, clinical, research, and public health experts have observed that this disease does not affect all individuals alike.…”

Section: Introductionmentioning

confidence: 99%

Systematic Review and Meta-Analysis of Sex-Specific COVID-19 Clinical Outcomes

et al. 2020

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To successfully mitigate the extraordinary devastation caused by the Coronavirus disease 2019 (COVID-19) pandemic, it is crucial to identify important risk factors for this disease. One such neglected health determinant is the sex of the patient. This is an essential clinical characteristic, as it can factor into a patient's clinical management and preventative measures. Some clinical studies have shown disparities in the proportion between males and females that have more severe clinical outcomes or, subsequently, die from this disease. However, this association has not been unequivocally established. Thus, the purpose of this investigation was to examine the association between male sex and COVID-19 severity. We systematically reviewed the literature, identified studies that matched predetermined selection criteria, and performed a meta-analysis to evaluate the proportion of males among four disease severity categories. Appropriate assessment strategies were implemented to assess and minimize potential biases. The results of this meta-analysis indicated that males constituted a significantly higher proportion of those who had adverse clinical outcomes and died from COVID-19. As the coronavirus spread from the East to the West, male sex remained a consistent risk factor. Our results support the establishment of the male sex as an important risk factor for this disease. Early identification and appropriate medical care for males with lab-confirmed COVID-19 may substantially change the course of clinical prognosis, resulting in greater numbers of lives saved.

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Section: Introductionmentioning

confidence: 99%

Systematic Review and Meta-Analysis of Sex-Specific COVID-19 Clinical Outcomes

et al. 2020

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“…The random transcriptional inactivation of X chromosomes in females may also help offset certain mutation-related dysregulation of the immune system (Taneja, 2018). Differences in endocrine system regulation in females compared to males significantly affect disease processes including respiratory, cardiovascular, and renal disease (Hilliard et al, 2013; Blenck et al, 2016; Channappanavar et al, 2017; Palmisano et al, 2018; Vermillion et al, 2018; Wensveen et al, 2019). As nations across the world navigate their way through the Coronavirus disease 2019 (COVID-19) pandemic, clinical, research, and public health experts have observed that this disease does not affect all individuals alike.…”

Section: Introductionmentioning

confidence: 99%

Systematic Review and Meta-Analysis of Sex-Specific COVID-19 Clinical Outcomes

Galbadage

Peterson

Awada

et al. 2020

Preprint

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To successfully mitigate the extraordinary devastation caused by the Coronavirus disease 2019 (COVID-19) pandemic, it is crucial to identify important risk factors for this disease. One such neglected health determinant is the sex of the patient. This is an essential clinical characteristic, as it can factor into a patient's clinical management and preventative measures.Some clinical studies have shown disparities in the proportion between males and females that have more severe clinical outcomes or, subsequently, die from this disease. However, this association has not been unequivocally established. Thus, the purpose of this investigation was to examine the association between male sex and COVID-19 severity. We systematically reviewed the literature, identified non-randomized studies that matched predetermined selection criteria, and performed a meta-analysis to evaluate the proportion of males among four disease severity categories. Appropriate assessment strategies were implemented to assess and minimize potential biases. The results of this meta-analysis indicated that males constituted a significantly higher proportion of those who had adverse clinical outcomes and died from COVID-19. As the coronavirus spread from the East to the West, male sex remained a consistent risk factor. Our results support the establishment of the male sex as an important risk factor for this disease. Early identification and appropriate medical care for males with lab-confirmed COVID-19 may substantially change the course of clinical prognosis, resulting in greater numbers of lives saved.All rights reserved. No reuse allowed without permission.

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“…Mice deficient in adiponectin fail to effectively modulate metabolic homeostasis ( 30 ). Leptin increases immune cell development, chemotaxis, and cytokine secretion ( 31 , 32 ). Moreover, M1 and M2 macrophages in adipose tissues have opposing effects on insulin responses in that M1 macrophages promote insulin resistance whereas M2-macrophages enhance insulin sensitivity ( 33 , 34 ).…”

Section: Bidirectional Immune-endocrine Interactions Of the Hpt Axismentioning

confidence: 99%

Dynamic Interactions Between the Immune System and the Neuroendocrine System in Health and Disease

Klein

2021

Front. Endocrinol.

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The immune system and the neuroendocrine system share many common features. Both consist of diverse components consisting of receptors and networks that are widely distributed throughout the body, and both sense and react to external stimuli which, on the one hand control mechanisms of immunity, and on the other hand control and regulate growth, development, and metabolism. It is thus not surprising, therefore, that the immune system and the neuroendocrine system communicate extensively. This article will focus on bi-directional immune-endocrine interactions with particular emphasis on the hormones of the hypothalamus-pituitary-thyroid (HPT) axis. New findings will be discussed demonstrating the direct process through which the immune system-derived thyroid stimulating hormone (TSH) controls thyroid hormone synthesis and bone metamorphosis, particularly in the context of a novel splice variant of TSHβ made by peripheral blood leukocytes (PBL). Also presented are the ways whereby the TSHβ splice variant may be a contributing factor in the development and/or perpetuation of autoimmune thyroid disease (AIT), and how systemic infection may elicit immune-endocrine responses. The relationship between non-HPT hormones, in particular adipose hormones, and immunity is discussed.

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‘Beauty and the beast’ in infection: How immune–endocrine interactions regulate systemic metabolism in the context of infection

Cited by 29 publications

References 165 publications

Systematic Review and Meta-Analysis of Sex-Specific COVID-19 Clinical Outcomes

Systematic Review and Meta-Analysis of Sex-Specific COVID-19 Clinical Outcomes

Systematic Review and Meta-Analysis of Sex-Specific COVID-19 Clinical Outcomes

Dynamic Interactions Between the Immune System and the Neuroendocrine System in Health and Disease

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