Beau’s line in COVID-19 after a long ICU stay

Paula, Jéssica Alves de; Franck, Claudia; Justino, Sandra; Leite, Luíza Silva; Junior, Odery Ramos; Rabito, Estela Iraci

doi:10.20960/nh.04131

Cited by 2 publications

(7 citation statements)

References 13 publications

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“…As observed from our results, Beau's lines were reported in only two cases after the administration of the COVID-19 vaccine, specifically of the Pfizer-BioNTech vaccine [19,21]. In both cases, Beau's lines were observed within the first 6 weeks in females aged 64 and 76 years old.…”

Section: Discussionsupporting

confidence: 74%

“…All included studies were published between 2020 and 2024 [ 9 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. The studies were conducted in different areas around the world, including the USA (three studies), Germany (one study), Canada (one study), Turkey (one study), Brazil (one study), Japan (one study), and Greece (one study).…”

Section: Resultsmentioning

confidence: 99%

“…All included studies documented Beau’s lines after COVID-19 vaccination (two studies) [ 19 , 21 ] or after COVID-19 infection (seven studies) [ 9 , 14 , 15 , 16 , 17 , 18 , 20 ]. One study reported two children, 2 and 5 years of age, while in the remaining seven isolated cases (four males, three females), the mean age was 60 years old.…”

Section: Resultsmentioning

confidence: 99%

“…Mean onset time after COVID-19 infection was approximately 3 months, while mean resolution time calculated from the available data was 6 months. Onset in the two studies reporting Beau’s lines after vaccination was 7 days and 6 weeks, respectively, with resolution reported after 2 months and 17 weeks, respectively [ 19 , 21 ]. In the case–control study [ 9 ], as well as in two reported cases, the appearance of Beau’s lines was associated with a prior severe COVID-19 infection [ 14 , 20 ].…”

Section: Resultsmentioning

confidence: 99%

“…As seen in Table 1 , these transverse indentations resolved within a few weeks to months. It should be noted that, although Ricardo et al reported the appearance of Beau’s lines after COVID-19 vaccination, the described patient also had a previous asymptomatic COVID-19 infection 6 months ago [ 19 ]. Despite the report of these two cases, further investigation is warranted to establish a possible association between SARS-CoV-2 vaccination and Beau’s lines, as well as the possible causative pathways.…”

Section: Discussionmentioning

confidence: 99%

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Beau’s Lines and COVID-19; A Systematic Review on Their Association

Agouridis,

Mastori-Kourmpani,

Antoniou

et al. 2024

Pathogens

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Background: Beau’s lines are transverse grooves in the nail plate that result from transient interruption of the growth of the proximal nail matrix after severe disease. The aim of this study is to systematically report all evidence on the association of Beau’s lines with COVID-19 infection or vaccination against COVID-19. Methods: PubMed and Scopus databases were searched up to January 2024 for articles reporting Beau’s lines associated with COVID-19 infection or vaccination for COVID-19. PROSPERO ID: CRD42024496830. Results: PubMed search identified 299 records while Scopus search identified 18 records. After screening the bibliography, nine studies including 35 cases were included in our systematic review. The studies were reported from different areas around the world. Included studies documented Beau’s lines following COVID-19 vaccination (two studies) or after COVID-19 infection (seven studies). High variability was recorded in onset and resolution times among included cases, averaging 3 months and 6 months after COVID-19 infection, respectively. In the two studies reporting Beau’s lines after vaccination, onset was at 7 days and 6 weeks and resolution occurred after 8 and 17 weeks, respectively. Conclusions: To the best of our knowledge, this is the first systematic review reporting the association of Beau’s lines with COVID-19 infection and vaccination. Severe immune response can result in the formation of these nail disorders. Of importance, Beau’s lines represent a potential indicator of prior severe COVID-19 infection or vaccination for COVID-19, as well as a sign of long COVID-19 syndrome.

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Section: Discussionsupporting

confidence: 74%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Beau’s Lines and COVID-19; A Systematic Review on Their Association

Agouridis,

Mastori-Kourmpani,

Antoniou

et al. 2024

Pathogens

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Unravelling Beau's lines as a potential indicator of severe immune response in COVID-19 and reinfection

Agouridis,

Ntzani,

Anastasiou

et al. 2024

European Journal of Case Reports in Internal Medicine

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Background: Beau's lines are transverse grooves in the nail plate that result from transient interruption of the growth of the proximal nail matrix. These rare nail disorders can be triggered mostly by infections or systemic diseases. Case Description: We describe a 65-year-old man who presented with nail changes on all fingernails. The patient, a non-smoker with no medication history, had severe immune responses during two hospitalisations, 9 and 4 months ago, for COVID-19. Both hospitalisations were accompanied by markedly elevated interleukin-6 levels, and treatment with tocilizumab on top of dexamethasone was required. The present examination revealed Beau's lines which were associated with both prior COVID-19 infections. Conclusions: Although nail changes look harmless, seeking Beau's lines during the physical examination might indicate past severe COVID-19 infection and a higher probability for reinfection and rehospitalisation.

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Beau’s line in COVID-19 after a long ICU stay

Cited by 2 publications

References 13 publications

Beau’s Lines and COVID-19; A Systematic Review on Their Association

Beau’s Lines and COVID-19; A Systematic Review on Their Association

Unravelling Beau's lines as a potential indicator of severe immune response in COVID-19 and reinfection

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