Beam collimation and bolusing material optimizations for 10boron neutron capture enhancement of fast neutron (BNCEFN): definition of the optimum irradiation technique

Fast Neutron Beams for Boron Neutron Capture Therapy?

“…In the upper energy range, for small fields the values and spatial distributions of D BNC turn out to be unfavourable compared to large fields and smaller energies. This was already noted by Pignol et al [33], Poeller [34] and others. Better values are obtained at lower energies at the cost, however, of a moderate loss in quality of dose conformation as a consequence of the increasing influence of neutron scatter.…”

“…To make dependencies clearer, the data are connected by simple spline curves. Results from other research groups in the field have been included for comparison [4,5,22,28,33,34]. In addition, we have included fluence to dose ratios F for two epithermal reactor neutron beams one of which is in charge with radiation therapy [24,32,44].…”

“…We have not tried to optimize the thermal neutron flux by inserting filters into the beam as done by Kota and others [21,22,33] because the photons from the irradiated filter material introduce additional radiation burden.…”

Design of a boron neutron capture enhanced fast neutron therapy assembly

“…It was also used to verify the design of the BNCEFNT reflective assembly. Moderation and reflection of neutrons using graphite, water, or heavy water around the head phantom was studied by Pignol [48] for Boron Neutron Capture…”

Development of a Boron Neutron Capture Enhanced Fast Neutron Therapy Beam

“…A 20 × 20 cm 2 beam produced a dose enhancement of 10.4% per 100-ppm 10 B [28]. Further studies by Paquis and Pignol to increase the PDE for the Nice Biomedical Cyclotron have focused on the addition of high Z material collimation near the patients head [23,29]. The head was assumed to be surrounded by a block of graphite.…”