Be resistant to apoptosis: a host factor from gingival fibroblasts

Cheng, Ruyue; Hu, Tao; Bhowmick, Neil A.

doi:10.1038/cddis.2015.350

Cited by 14 publications

(15 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The treatment for gingival bleeding may influence the final outcome: gingivitis or periodontitis. Proper treatment will relieve gingivitis, while some uncontrolled gingivitis may progress to irreversible periodontitis, which can ultimately lead to tooth loss [ 39 , 40 ]. Figure 2 shows the possible treatments for students suffering from gingival bleeding.…”

Section: Resultsmentioning

confidence: 99%

The effects of oral health education regarding periodontal health on non-dental undergraduates in southwestern China—exploring the feasibility of an e-learning course for oral health promotion

Zhu

et al. 2021

BMC Oral Health

View full text Add to dashboard Cite

Background The high prevalence of periodontal diseases is an important oral health problem worldwide. It is necessary to increase public knowledge on and influence attitudes towards periodontal diseases in order to prevent them. However, the effect of oral health education (OHE) as a primary preventive method in China is unsatisfactory. The aim of this study is to investigate the feasibility of extending an e-learning course regarding periodontal health by comparing the effects of oral health education regarding periodontal health (OHE-PH) on dental and non-dental students and the effects between a traditional course and an e-learning course among non-dental students at Sichuan University. Methods A quasi-experimental study with a pre-test and a post-test was performed. A total of 217 dental students and 134 non-dental students attended a traditional course; 69 non-dental students attended an e-learning course. Before- and after-course questionnaires about periodontal health knowledge, attitudes and behaviours were administered. Results After the traditional/e-learning course, the knowledge of both dental and non-dental students about periodontal diseases and self-reported behaviours for gingival bleeding and oral care improved. The non-dental students reached or surpassed the level of dental students before the course. The non-dental students taking the e-learning course performed better in some areas than those taking the traditional course. Conclusions OHE-PH was effective for dental and non-dental students. The e-learning course on OHE-PH was sufficient for improving knowledge and self-reported behaviours among non-dental undergraduates and was even better than the traditional course in some areas. The e-learning course may be an effective method for periodontal health education and oral health promotion among undergraduates.

show abstract

Section: Resultsmentioning

confidence: 99%

The effects of oral health education regarding periodontal health on non-dental undergraduates in southwestern China—exploring the feasibility of an e-learning course for oral health promotion

Zhu

et al. 2021

BMC Oral Health

View full text Add to dashboard Cite

show abstract

“…At present, the aetiology of periodontitis is characterised by both dysbiosis of the host and oral microbiota. 1 Various mediators affect the balance in chronic inflammation. The pro-inflammatory cytokines include IL-1β, tumour necrosis factor (TNF)-α, IL-6 and IL-17, which lead to periodontal inflammation and tissue injury.…”

Section: Clinical Evidence Regarding Interleukin(il)-1βmentioning

confidence: 99%

Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review

Cheng

et al. 2020

Int J Oral Sci

152

View full text Add to dashboard Cite

Interleukin(IL)-1β, a pro-inflammatory cytokine, was elevated and participates in periodontitis. Not only the link between IL-1β and periodontitis was proved by clinical evidence, but also the increased IL-1β triggers a series of inflammatory reactions and promotes bone resorption. Currently, IL-1β blockage has been therapeutic strategies for autoimmune and autoinflammatory diseases such as rheumatoid arthritis, cryopyrin-associated periodic syndromes, gout and type II diabetes mellitus. It is speculated that IL-1β be a potential therapeutic target for periodontitis. The review focuses on the production, mechanism, present treatments and future potential strategies for IL-1β in periodontitis.

show abstract

“…Healthy periodontium maintain host-microbe homeostasis in which a controlled immuno-inflammatory state is kept. Imbalanced host-microbe interaction lead to disease initiation and progression (Cheng et al, 2015b ). Several Gram-negative anaerobic and microaerophilic bacterial species, such as Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia , and Aggregatibacter actinomycetemcomitans ( A. actinomycetemcomitans ) and the corresponding host responses, are the predominant etiological factors of periodontitis (Kinane, 2001 ).…”

Section: Introductionmentioning

confidence: 99%

Porphyromonas gingivalis-Derived Lipopolysaccharide Combines Hypoxia to Induce Caspase-1 Activation in Periodontitis

Cheng

Zhang

et al. 2017

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Periodontitis is defined as inflammation affecting the supporting tissue of teeth. Periodontal pathogens initiate the disease and induce inflammatory host response. Hypoxia may accelerate the process by producing pro-inflammatory factors. The aim of this study is to investigate the effect of Porphyromonas gingivalis (P. gingivalis) lipopolysaccharides (LPS) and Escherichia coli (E. coli) LPS in inducing caspase-1 activation in normoxic or hypoxic phases. The results showed that healthy gingiva was in a normoxic phase (HIF-1α negative). However, hypoxia appeared in periodontitis, in which NLRP3, cleaved-caspase-1, interleukin 1 beta (IL-1β) and caspase-1-induced cell death was enhanced in periodontitis specimens. The in vitro experiment showed that P. gingivalis LPS slightly decreased the level of NLRP3 and IL-1β in gingival fibroblasts under normoxia. Surprisingly, hypoxia reversed the effects of P. gingivalis LPS, highly promoted caspase-1 activation and IL-1β maturation. E. coli LPS, a kind of pathogen-associated molecular pattern (PAMP) was chosen to simulate the effect of Gram-negative microbiota. Different from P. gingivalis LPS, E. coli LPS enhanced IL-1β maturation both in normoxia and hypoxia. Moreover, E. coli LPS turned normoxia into hypoxia phase in experimental periodontitis model, which may subsequently propel the inflammatory effect of P. gingivalis LPS. It was concluded that E. coli LPS induced a hypoxic phase, which is a combing pathological factor of P. gingivalis LPS in caspase-1 activating and IL-1β maturation in periodontal inflammation.

show abstract

Be resistant to apoptosis: a host factor from gingival fibroblasts

Cited by 14 publications

References 11 publications

The effects of oral health education regarding periodontal health on non-dental undergraduates in southwestern China—exploring the feasibility of an e-learning course for oral health promotion

The effects of oral health education regarding periodontal health on non-dental undergraduates in southwestern China—exploring the feasibility of an e-learning course for oral health promotion

Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review

Porphyromonas gingivalis-Derived Lipopolysaccharide Combines Hypoxia to Induce Caspase-1 Activation in Periodontitis

Contact Info

Product

Resources

About