Be(a)ware of Leukocytosis in Papillary Thyroid Cancer

Laskou, Styliani; Sapalidis, Konstantinos; Topalidis, Christos; Κoletsa, Triantafyllia; Κεσίσογλου, Ισαάκ

doi:10.1155/2022/5799432

Cited by 1 publication

(2 citation statements)

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“…Both the efficacy and the duration of the method depend on surgical incision length, as well as the topical agent used. 4 In the same clinical setting, the use of NSAIDs as adjuncts to ropivacaine infiltration promoted an enhanced analgesic effect.11,19…”

Section: Discussionmentioning

confidence: 99%

“…Evidence indicates that thyroidectomy wound infiltration constitutes an easy-to-implement technique operated by the surgeon himself, while it elongates the time frame until rescue analgesia. 4 Currently, magnesium sulfate is widely applied in the perioperative setting for its multifactorial properties and has been shown to decrease the anesthesia and analgesia requirements effectively. 5-8 Relevant reports indicate that the implementation of wound infiltration with magnesium sulfate and ropivacaine mixture seems to reduce postoperative tramadol requirements after radical prostatectomy.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy and Safety of Magnesium Sulfate as an Adjunct to Ropivacaine Wound Infiltration in Thyroid Surgery.

Laskou,

Tsaousi,

Pourzitaki

et al. 2024

Preprint

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Objective: To assess wound infiltration with ropivacaine plus magnesium sulfate for pain relief following thyroid surgery. Background: Analgesia with local anesthetics following surgery is a critical element of alleviating postoperative pain. However, such strategies in neck surgery has not been a well-established practice. Methods: This prospective double-blind randomized study enrolled 68 patients who underwent thyroid surgery. Concerning the solution used for surgical wound infiltration the study participants were randomly allocated into three groups: 1) 100 mg of ropivacaine (Group R), 2) 100mg of ropivacaine plus magnesium sulfate 10mg/kg (Group RMg), and 3) normal saline which served as placebo (Group P). Pain perception both at rest and at movement, was measured using the Visual Analogue Scale (VAS) at 30 minutes, as well as 1, 2, 4, 6, 12, and 24 hours postoperatively. The total consumption of analgesics in morphine equivalents was also recorded. Moreover, adverse effects and patient satisfaction were recorded. Cortisol, TNF-α, and IL-6 levels were measured 30 minutes before infiltration, 6 hours and 24 hours postoperatively. Results: Demographics and clinical characteristics were similar between the groups. The VAS scores at rest and during movement were significantly lower in the RMg group compared to saline or ropivacaine groups. Total analgesic consumption was also significantly lower in the RMg group. No operational, wound or infiltration-related adverse effects were recorded in the study groups. Better overall satisfaction was obtained for the group RMg. Conclusions: Ropivacaine plus magnesium sulfate wound infiltration provided better pain control and analgesic effect was more significant, contributing to effective postoperative analgesia in patients undergoing thyroid surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%