BDNF val66met modulates the association between childhood trauma, cognitive and brain abnormalities in psychoses

Aas, Monica; Haukvik, Unn K.; Djurovic, Srdjan; Bergmann, Ørjan; Athanasiu, Lavinia; Tesli, Martin; Hellvin, Tone; Steen, Nils Eiel; Agartz, Ingrid; Lorentzen, Steinar; Sundet, Kjetil; Andreassen, Ole A.; Melle, Ingrid

doi:10.1016/j.pnpbp.2013.07.008

Cited by 89 publications

(69 citation statements)

References 62 publications

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“…Consistent with functional studies and previous GxE research with the Val66Met polymorphism (i.e. : Aas et al, 2013;Alemany et al, 2011;Chen et al, 2006), we hypothesised that individuals carrying the Met allele (Met/Met and Val/Met) who have been exposed to childhood trauma are at higher risk of presenting with PEs in adulthood as compared with Val/Val subjects.…”

Section: Accepted Manuscriptsupporting

confidence: 69%

“…13 childhood trauma exposure showed poorer cognitive functioning, reduced hippocampal volumes and larger ventricles (Aas et al, 2013). However, these findings have not been replicated in other samples (Hernaus et al, 2014).…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 82%

“…The second study by Ramsay and colleagues attempted to replicate those findings, but was unable to find any significant interaction (Ramsay et al, 2013). Despite these contradictory results, there is independent evidence indicating that this polymorphism moderates the effects of stress exposure on cognition, brain structure and anxiety (Aas et al, 2013;Chen et al, 2006), in line with Alemany et al's findings.…”

Section: Accepted Manuscriptmentioning

confidence: 90%

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Childhood trauma, BDNF Val66Met and subclinical psychotic experiences. Attempt at replication in two independent samples

Castro-Català

Nierop

Barrantes‐Vidal

et al. 2016

Journal of Psychiatric Research

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Childhood trauma exposure is a robust environmental risk factor for psychosis. However, not all exposed individuals develop psychotic symptoms later in life. The Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265) has been suggested to moderate the psychosis-inducing effects of childhood trauma in clinical and nonclinical samples. Our study aimed to explore the interaction effect between childhood trauma and the BDNF Val66Met polymorphism on subclinical psychotic experiences (PEs). This was explored in two nonclinical independent samples: an undergraduate and technical-training school student sample (n=808, sample 1) and a female twin sample (n=621, sample 2). Results showed that childhood trauma was strongly associated with positive and negative PEs in nonclinical individuals. A BDNF Val66Met x childhood trauma effect on positive PEs was observed in both samples. These results were discordant in terms of risk allele: while in sample 1 Val allele carriers, especially males, were more vulnerable to the effects of childhood trauma regarding PEs, in sample 2 Met carriers presented higher PEs scores when exposed to childhood trauma, compared with Val carriers. Moreover, in sample 2, a significant interaction was also found in relation to negative PEs. Our study partially replicates previous findings and suggests that some individuals are more prone to develop PEs following childhood trauma because of a complex combination of multiple factors. Further studies including genetic, environmental and epigenetic factors may provide insights in this field.

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Section: Accepted Manuscriptsupporting

confidence: 69%

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 82%

Section: Accepted Manuscriptmentioning

confidence: 90%

See 1 more Smart Citation

Childhood trauma, BDNF Val66Met and subclinical psychotic experiences. Attempt at replication in two independent samples

Castro-Català

Nierop

Barrantes‐Vidal

et al. 2016

Journal of Psychiatric Research

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“…In the present review, we identified one study showing that met carriers diagnosed with BD have smaller hippocampi volumes and larger ventricles than val/val carriers. Moreover, met carriers were seen to encounter more difficulties in verbal fluency and working memory tasks than the val/val group (55). …”

Section: Results Of Identified Studiesmentioning

confidence: 99%

Inflammatory mediators of cognitive impairment in bipolar disorder

Bauer

Pascoe

Wollenhaupt-Aguiar

et al. 2014

Journal of Psychiatric Research

103

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Objectives Recent studies have pointed to neuroinflammation, oxidative stress and neurotrophic factors as key mediators in the pathophysiology of mood disorders. Little is however known about the cascade of biological episodes underlying the cognitive deficits observed during the acute and euthymic phases of bipolar disorder (BD). The aim of this review is to assess the potential association between cognitive impairment and biomarkers of inflammation, oxidative stress and neurotrophic activity in BD. Methods Scopus (all databases), Pubmed and Ovid Medline were systematically searched with no language or year restrictions, up to November 2013, for human studies that collected both inflammatory markers and cognitive data in BD. Selected search terms were bipolar disorder, depression, mania, psychosis, inflammatory, cognitive and neurotrophic. Results Ten human studies satisfied the criteria for consideration. The findings showed that high levels of peripheral inflammatory-cytokine, oxidative stress and reduced brain derived neurotrophic factor (BDNF) levels were associated with poor cognitive performance. The BDNF val66met polymorphism is a potential vulnerability factor for cognitive impairment in BD. Conclusions Current data provide preliminary evidence of a link between the cognitive decline observed in BD and mechanisms of neuroinflammation and neuroprotection. The identification of BD specific inflammatory markers and polymorphisms in inflammatory response genes may be of assistance for therapeutic intervention.

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“…Interestingly, psychotic patients with the met allele of the BDNF Val66met polymorphism and exposed to childhood trauma also had significant reduction of the hippocampus volume (Aas et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

The effect of lifetime adversities on resistance to antipsychotic treatment in schizophrenia patients

Hassan

Luca

2015

Schizophrenia Research

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BDNF val66met modulates the association between childhood trauma, cognitive and brain abnormalities in psychoses

Cited by 89 publications

References 62 publications

Childhood trauma, BDNF Val66Met and subclinical psychotic experiences. Attempt at replication in two independent samples

Childhood trauma, BDNF Val66Met and subclinical psychotic experiences. Attempt at replication in two independent samples

Inflammatory mediators of cognitive impairment in bipolar disorder

The effect of lifetime adversities on resistance to antipsychotic treatment in schizophrenia patients

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