BDNF Val66Met and reward-related brain function in adolescents: role for early alcohol consumption

Nees, Frauke; Witt, Stephanie H.; Dinu-Biringer, Ramona; Lourdusamy, Anbarasu; Tzschoppe, Jelka; Vollstädt‐Klein, Sabine; Millenet, Sabina; Bach, Christiane; Poustka, Luise; Banaschewski, Tobias; Barker, Gareth J.; Bokde, Arun L.W.; Bromberg, Uli; Büchel, Christian; Conrod, Patricia J.; Frank, Josef; Frouin, Vincent; Gallinat, Jürgen; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Mann, Karl; Martinot, Jean‐Luc; Paus, Tomáš; Pausová, Zdenka; Robbins, Trevor W.; Smolka, Michael N.; Rietschel, Marcella; Schumann, Günter; Flor, Herta

doi:10.1016/j.alcohol.2014.12.004

Cited by 26 publications

(26 citation statements)

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“…Although it was not the only region involved in this association it had one of the strongest correlations. Also, (Nees, et al, 2015) reported that adolescent Met carriers with high levels of current alcohol use showed reduced MID anticipatory activation in the left putamen compared to Met carriers with low current use. In addition, low left putamen response on MID outcomes predicted likelihood of drinking 2 years later.…”

Section: Discussionmentioning

confidence: 99%

“…People who are high in impulsivity show less differentiation in mesolimbic fMRI among small incentive values (Vaidya, et al, 2013). In addition, youths and adults with ADHD (Hoogman, et al, 2011; Plichta & Scheres, 2014; Scheres, Milham, Knutson, & Castellanos, 2007), adolescent smokers (Peters, et al, 2011) and adolescent Met carriers (Nees, et al, 2015) also show reduced mesolimbic responses on the MID. On the other hand, greater mesolimbic MID response has been associated with higher approach motivation (Hahn, et al, 2009; Kennis, Rademaker, & Geuze, 2013; Simon, et al, 2010), trait positive affect (Wu, Samanez-Larkin, Katovich, & Knutson, 2014), higher sensation seeking (Abler, Walter, Erk, Kammerer, & Spitzer, 2006; Bjork, Knutson, & Hommer, 2008), and presence of or risk for externalizing disorders (Bjork, Chen, Smith, & Hommer, 2010; Bjork, Smith, Chen, & Hommer, 2011; Heitzeg, et al, 2014; Hoogman, et al, 2011; Yau, et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…In many cases, only gains and neutral conditions were included (Galvan, et al, 2006; Geier, et al, 2010; Heitzeg, et al, 2014; Nees, et al, 2012; Nees, et al, 2015; Peters, et al, 2011; Schneider, et al, 2012; Vaidya, et al, 2013); hence, a full appreciation of incentive valence is not possible without including losses. Also, some prior studies did not manipulate the magnitude of incentives (or did not convey the magnitude information to the subjects).…”

Section: Introductionmentioning

confidence: 99%

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Modulation of meso-limbic reward processing by motivational tendencies in young adolescents and adults

et al. 2016

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Adolescence is a particularly vulnerable period for the onset of substance use disorders and other psychopathology. Individual variability in motivational tendencies and temperament and significant changes in functional brain organization during adolescence are important factors to consider in the development of substance use and dependence. Recent conceptualizations suggest that sensitivity to reward is heightened in adolescence and that this motivation tendency may precipitate subsequent substance abuse. The present study examined the role of personality traits in mesolimbic neurobehavioral response on a monetary incentive delay (MID) task in young adolescents (11–14 years) and emerging adults (18–25 years) using functional magnetic resonance imaging. As a group, adolescents were not more sensitive to gains than losses compared to adults during either anticipatory and feedback phases; instead, compared to adults they showed less sensitivity to incentive magnitude in mesolimbic circuitry during anticipation and feedback stages. However, personality modulated this response such that adolescents high in impulsivity or low in avoidance tendencies showed greater gain sensitivity and adolescents high in avoidance showed greater loss sensitivity during cue anticipation. In adults, mesolimbic response was modulated by the impulsivity construct such that high-impulsive adults showed reduced magnitude sensitivity during both anticipation and feedback compared to low impulsive adults. The present findings suggest that impulsive personality significantly modulates mesolimbic reward response during both adolescence and adulthood but avoidance and approach tendencies also modulate this response in adolescents. Moreover, personality modulated incentive valence in adolescents but incentive magnitude in adults. Collectively, these findings suggest that mesolimbic reward circuitry function is modulated by somewhat different parameters in adolescence than in adulthood.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Modulation of meso-limbic reward processing by motivational tendencies in young adolescents and adults

et al. 2016

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“…Finally, we found that a single point mutation in the BDNF gene which produces a valine to methionine substitution results in compulsive heavy alcohol use despite negative consequences in mice . Interestingly, this single point mutation is also associated with an early onset of relapse in alcoholics undergoing treatment (Wojnar et al, 2009), and with an increased likelihood to respond to alcohol cues in adolescents (Nees et al, 2015). The Val66Met BDNF polymorphism can also predict the level of alcohol intake in alcohol-dependent patients when assessed together with polymorphisms for dopaminergic genes (Klimkiewicz et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Differential Correlation of Serum BDNF and microRNA Content in Rats with Rapid or Late Onset of Heavy Alcohol Use

Ehinger

Phamluong

Darevesky

et al. 2019

Preprint

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Heavy alcohol use reduces the levels of the brain-derived neurotrophic factor (BDNF) in the prefrontal cortex of rodents through the upregulation of microRNAs targeting BDNF mRNA. In humans, an inverse correlation exists between circulating blood levels of BDNF and the severity of psychiatric disorders including alcohol abuse. Here, we set out to determine whether a history of heavy alcohol use produces comparable alterations in the blood of rats. We used an intermittent access to 20% alcohol using the 2-bottle choice paradigm (IA20%2BC), and measured circulating levels of BDNF protein and microRNAs in the serum of Long-Evans rats before and after 8-weeks of excessive alcohol intake. We observed that the drinking profile of heavy alcohol users is not unified; Whereas 70% of the rats gradually escalate their alcohol intake (Late Onset), 30% of alcohol users exhibit a very Rapid Onset of drinking (Rapid Onset). We found that serum BDNF levels are negatively correlated with alcohol intake in both Rapid Onset and Late Onset rats. In contrast, increased expression of the microRNAs (miRs) targeting BDNF, miR30a-5p, miR-195-5p, miR191-5p and miR206-3p, was detected only in the Rapid Onset rats. Finally, we report that the alcohol-dependent molecular changes are not due to alterations in platelet number. Our data suggest that rats exhibit both Late and Rapid Onset of alcohol intake. We further show that heavy alcohol use produces comparable changes in BDNF protein levels in both groups. However, circulating microRNAs are responsive to alcohol only in the Rapid Onset rats.

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“…Noteworthy, BDNF is involved with neuronal survival, development and plasticity (Thoenen, ), and many psychiatric disorders such as depression, stress, anxiety, pain, and drug addiction (Horger et al, ; Hall et al, ; Murakami et al, ; Pandey et al, ; Davis, ; Merighi et al, ). The possibility of BDNF as a biomarker of alcohol abuse is corroborated by its serum levels changes after heavy alcohol intake and polymorphisms in BDNF gene in people with alcohol dependence or with alcohol‐related risk phenotypes (Wojnar et al, ; Bus et al, ; Nees et al, ).…”

Section: Introductionmentioning

confidence: 99%

StandardizedPassiflora incarnataL. Extract Reverts the Analgesia Induced by Alcohol Withdrawal in Rats

et al. 2017

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Passiflora incarnata L. (Passifloraceae) has been traditionally used for treatment of anxiety, insomnia, drug addiction, mild infections, and pain. The aim of this study was to investigate the effect of a commercial extract of P. incarnata in the analgesia induced by alcohol withdrawal syndrome in rats. In addition, brain-derived neurotrophic factor and interleukin-10 levels were evaluated in prefrontal cortex, brainstem, and hippocampus. Male adult rats received by oral gavage: (1: water group) water for 19 days, 1 day interval and water (8 days); (2: P. incarnata group) water for 19 days, 1 day interval and P. incarnata 200 mg/kg (8 days); (3: alcohol withdrawal group) alcohol for 19 days, 1 day interval and water (8 days); and (4: P. incarnata in alcohol withdrawal) alcohol for 19 days, 1 day interval and P. incarnata 200 mg/kg (8 days). The tail-flick and hot plate tests were used as nociceptive response measures. Confirming previous study of our group, it was showed that alcohol-treated groups presented an increase in the nociceptive thresholds after alcohol withdrawal, which was reverted by P. incarnata, measured by the hot plate test. Besides, alcohol treatment increased brain-derived neurotrophic factor and interleukin-10 levels in prefrontal cortex, which was not reverted by P. incarnata. Considering these results, the P. incarnata treatment might be a potential therapy in the alcohol withdrawal syndrome. Copyright © 2017 John Wiley & Sons, Ltd.

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BDNF Val66Met and reward-related brain function in adolescents: role for early alcohol consumption

Cited by 26 publications

References 63 publications

Modulation of meso-limbic reward processing by motivational tendencies in young adolescents and adults

Modulation of meso-limbic reward processing by motivational tendencies in young adolescents and adults

Differential Correlation of Serum BDNF and microRNA Content in Rats with Rapid or Late Onset of Heavy Alcohol Use

StandardizedPassiflora incarnataL. Extract Reverts the Analgesia Induced by Alcohol Withdrawal in Rats

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