BDNF-secreting capsule exerts neuroprotective effects on epilepsy model of rats

Kuramoto, Satoshi; Yasuhara, Takao; Agari, Takashi; Kondo, Akihiko; Meng, Jing; Kikuchi, Yoichiro; Shinko, Aiko; Wakamori, Takaaki; Kameda, Masahiro; Wang, Feifei; Kin, Kyohei; Edahiro, Satoru; Miyoshi, Yasuyuki; Date, Isao

doi:10.1016/j.brainres.2010.10.054

Cited by 26 publications

(34 citation statements)

References 44 publications

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“…On the other hand, several studies revealed anti-epileptic effects of BDNF [35]. Based on our studies, we confirmed that continuous administration of BDNF at low dose exerted anti-epileptic effects using encapsulated BDNF-producing cell transplantation as described in the prior section [42]. In the study, the capsule produced about 200–300 pg of BDNF per hour.…”

Section: Basic Research and Clinical Application For Epilepsysupporting

confidence: 85%

Regenerative Medicine for Epilepsy: From Basic Research to Clinical Application

Yasuhara

Agari

Kameda

et al. 2013

IJMS

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Epilepsy is a chronic neurological disorder, which presents with various forms of seizures. Traditional treatments, including medication using antiepileptic drugs, remain the treatment of choice for epilepsy. Recent development in surgical techniques and approaches has improved treatment outcomes. However, several epileptic patients still suffer from intractable seizures despite the advent of the multimodality of therapies. In this article, we initially provide an overview of clinical presentation of epilepsy then describe clinically relevant animal models of epilepsy. Subsequently, we discuss the concepts of regenerative medicine including cell therapy, neuroprotective agents, and electrical stimulation, which are reviewed within the context of our data.

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Section: Basic Research and Clinical Application For Epilepsysupporting

confidence: 85%

Regenerative Medicine for Epilepsy: From Basic Research to Clinical Application

Yasuhara

Agari

Kameda

et al. 2013

IJMS

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“…Most studies (Heinrich et al, 2011;Reibel et al, 2000) determined that the expression of BDNF increased following a seizure, which was consistent with our in vitro results. However, whether promoting epileptogenesis (HarteHargrove et al, 2013;Heinrich et al, 2011) or the antiepileptogenic effects (Kuramoto et al, 2011;Reibel et al, 2000) of BDNF had always been controversial. Emerging evidence suggests that activation of the BDNF receptor TrkB plays an essential, not merely regulatory, role in epileptogenesis in the animal model of SE (He et al, 2004;Kotloski and McNamara, 2010;Liu et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-132 aggravates epileptiform discharges via suppression of BDNF/TrkB signaling in cultured hippocampal neurons

et al. 2015

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“…Furthermore, as the grafted cells are encapsulated, they are immuno‐isolated from host immune attacks, resulting in prolonged survival and sustained release of growth factors in the vicinity of the degeneration. In an animal model of TLE, implantation of encapsulated cells genetically modified to express adenosine, BDNF and GDNF significantly supressed seizure activities and protected hippocampal neurons (Huber et al ., ; Kuramoto et al ., ; Kanter‐Schlifke et al ., ). The beneficial effects of the cell encapsulation approach have also been confirmed in animal models of AD, as well as in clinical trials.…”

Section: Role Of Biomaterials In Cell‐based Neuroregenerative Therapymentioning

confidence: 97%

Regenerative therapy for hippocampal degenerative diseases: lessons from preclinical studies

Venugopal

Chandanala

Prasad

et al. 2015

J Tissue Eng Regen Med

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Increase in life expectancy has put neurodegenerative diseases on the rise. Amongst these, degenerative diseases involving hippocampus like Alzheimer's disease (AD) and temporal lobe epilepsy (TLE) are ranked higher as it is vulnerable to excitotoxicity induced neuronal dysfunction and death resulting in cognitive impairment. Modern medicines have not succeeded in halting the progression of these diseases rendering them incurable and often fatal. Under such scenario, regenerative studies employing stem cells or their by-products in animal models of AD and TLE have yielded encourageing results. This review focuses on the distinct cell types, such as hippocampal cell lines, neural precursor cells, embryonic stem cells derived neural precursor cells, induced pluripotent stem cells, induced neurons and mesenchymal stem cells, which can be employed to rescue hippocampal functions in neurodegenerative diseases like AD and TLE. Besides, the divergent mechanisms through which cell based therapy confer neuroprotection, current impediments and possible improvements in stem cell transplantation strategies are discussed. Authors are aware of the voluminous literature available on this issue and have made a sincere attempt to put forth the current status of research in the field of cell based therapy concurrently discussing the promise it holds for combating neurodegenerative diseases like AD and TLE in the near future. Copyright © 2015 John Wiley & Sons, Ltd.

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BDNF-secreting capsule exerts neuroprotective effects on epilepsy model of rats

Cited by 26 publications

References 44 publications

Regenerative Medicine for Epilepsy: From Basic Research to Clinical Application

Regenerative Medicine for Epilepsy: From Basic Research to Clinical Application

MicroRNA-132 aggravates epileptiform discharges via suppression of BDNF/TrkB signaling in cultured hippocampal neurons

Regenerative therapy for hippocampal degenerative diseases: lessons from preclinical studies

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