BDNF protein expression in the hippocampus following exposure of rats to forced swimming stress

Булыгина, В. В.; Шишкина, Г. Т.; Berezova, I. V.; Дыгало, Н. Н.

doi:10.1134/s0012496611020116

Cited by 8 publications

(2 citation statements)

References 13 publications

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“…25 Correspondingly, in the present study, we observed a significant reduction in hippocampal BDNF levels combined with spatial learning and memory deterioration after prolonged stress exposure, in agreement with previous reports. 63,64 Current findings are consistent with the negative effect of prolonged stress on spatial learning and memory tested in the RAWM and BDNF levels in the hippocampus. 52 Additionally, they shed light on the negative influence nine weeks of chronic stress on hippocampus-dependent memory processes.…”

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confidence: 80%

Evaluation of the Effect of Hypericum triquetrifolium Turra on Memory Impairment Induced by Chronic Psychosocial Stress in Rats: Role of BDNF

Alzoubi

Abdel-Hafiz

Khabour

et al. 2020

DDDT

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Background: Chronic psychosocial stress impairs memory function and leads to a depression-like phenotype induced by a persistent status of oxidative stress. Hypericum perforatum L. (St. John's wort) is widely used to relieve symptoms of anxiety and depression; however, its long-term use is associated with adverse effects. Hypericum triquetrifolium Turra is closely related to H. perforatum. Both plants belong to Hypericaceae family and share many biologically active compounds. Previous work by our group showed that methanolic extracts of H. triquetrifolium have potent antioxidant activity as well as high hypericin content, a component that proved to have stress-relieving and antidepressant effects by other studies. Therefore, we hypothesized that H. triquetrifolium would reduce stress-induced cognitive impairment in a rat model of chronic stress. Objective: To determine whether chronic treatment with H. triquetrifolium protects against stress-associated memory deficits and to investigate a possible mechanism. Methods: The radial arm water maze (RAWM) was used to test learning and memory in rats exposed to daily stress using the resident-intruder paradigm. Stressed and unstressed rats received chronic H. triquetrifolium or vehicle. We also measured levels of brain-derived neurotrophic factor (BDNF) in the hippocampus, cortex and cerebellum. Results: Neither chronic stress nor chronic H. triquetrifolium administration affected performance during acquisition. However, memory tests in the RAWM showed that chronic stress impaired different post-encoding memory stages. H. triquetrifolium prevented this impairment. Furthermore, hippocampal BDNF levels were markedly lower in stressed animals than in unstressed animals, and chronic administration of H triquetrifolium chronic administration protected against this reduction. No significant difference was observed in the effects of chronic stress and/or H. triquetrifolium treatment on BDNF levels in the cerebellum and cortex. Conclusion: H. triquetrifolium extract can oppose stress-associated hippocampus-dependent memory deficits in a mechanism that may involve BDNF in the hippocampus.

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supporting

confidence: 80%

Evaluation of the Effect of Hypericum triquetrifolium Turra on Memory Impairment Induced by Chronic Psychosocial Stress in Rats: Role of BDNF

Alzoubi

Abdel-Hafiz

Khabour

et al. 2020

DDDT

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“…no significant changes were identified. Other authors have reported no changes in BDNF protein expression in the hippocampus 24 h after exposure to the forced swim test [45]. Schulte-Herbrüggen et al demonstrated that the levels of BNDF in the frontal cortex, hippocampus, and striatum were not altered after swimming stress in mice [46].…”

Section: Discussionmentioning

confidence: 97%

Immobility behavior during the forced swim test correlates with BNDF levels in the frontal cortex, but not with cognitive impairments

Borsoi

Antonio

Viana

et al. 2015

Physiology & Behavior

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Increased Expression of the Anti-Apoptotic Protein Bcl-xL in the Brain is Associated with Resilience to Stress-Induced Depression-Like Behavior

et al. 2012

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Clinical observations and the results of animal studies have implicated changes in neuronal survival and plasticity in both the etiology of mood disorders, especially stress-induced depression, and anti-depressant drug action. Stress may predispose individuals toward depression through down-regulation of neurogenesis and an increase in apoptosis in the brain. Substantial individual differences in vulnerability to stress are evident in humans and were found in experimental animals. Recent studies revealed an association between the brain anti-apoptotic protein B cell lymphoma like X, long variant (Bcl-xL) expression and individual differences in behavioral vulnerability to stress. The ability to increase Bcl-xL gene expression in the hippocampus in response to stress may be an important factor for determining the resistance to the development of stress-induced depression. Treatment with anti-depressant drugs may change Bcl-xL response properties. In the rat brainstem, expression of this anti-apoptotic gene becomes sensitive to swim stress during the long-term fluoxetine treatment, an effect that appeared concomitantly with the anti-depressant-like action of the drug in the forced swim test, suggesting that Bcl-xL may be a new target for depression therapy. The processes and pathways linking stress stimuli to behavior via intracellular anti-apoptotic protein are discussed here in the context of Bcl-xL functions in the mechanisms of individual differences in behavioral resilience to stress and anti-depressant-induced effects on the behavioral despair.

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BDNF protein expression in the hippocampus following exposure of rats to forced swimming stress

Cited by 8 publications

References 13 publications

<p>Evaluation of the Effect of <em>Hypericum triquetrifolium</em> Turra on Memory Impairment Induced by Chronic Psychosocial Stress in Rats: Role of BDNF</p>

<p>Evaluation of the Effect of <em>Hypericum triquetrifolium</em> Turra on Memory Impairment Induced by Chronic Psychosocial Stress in Rats: Role of BDNF</p>

Immobility behavior during the forced swim test correlates with BNDF levels in the frontal cortex, but not with cognitive impairments

Increased Expression of the Anti-Apoptotic Protein Bcl-xL in the Brain is Associated with Resilience to Stress-Induced Depression-Like Behavior

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