BDNF Level in the Rat Prefrontal Cortex Increases Following Chronic but Not Acute Treatment with Duloxetine, a Dual Acting Inhibitor of Noradrenaline and Serotonin Re-uptake

Mannari, Claudio; Origlia, Nicola; Scatena, Alessia; Debbio, Alessandro Del; Catena, Mario; Dell’Agnello, Grazia; Barraco, Alessandra; Giovannini, Luca; Dell’Osso, Liliana; Domenici, Luciano; Piccinni, Armando

doi:10.1007/s10571-007-9254-x

Cited by 56 publications

(48 citation statements)

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“…The mature form and the precursor form of BDNF play different roles in cell survival, synaptic plasticity and cognitive functions in health and pathology [46] . In animals, we recently showed that the mature, but not the precursor form of BDNF was significantly increased in the prefrontal cortex of rats treated for 14 days with duloxetine at 30 mg/kg/day [47] .…”

Section: Discussionmentioning

confidence: 99%

Associations between Brain-Derived Neurotrophic Factor Plasma Levels and Severity of the Illness, Recurrence and Symptoms in Depressed Patients

et al. 2010

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Background: There is increasing evidence that the brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of mood disorders and that its peripheral levels represent a reliable mirror of its concentration in the brain. The aim of the present study was to measure BDNF plasma levels in patients affected by major depression and to explore the possible relationship between the biological parameter and characteristics of the illness. Method: BDNF plasma levels were evaluated in 30 inpatients suffering from major depression, according to DSM-IV criteria, by means of a commonly employed ELISA method. The clinical characteristics were assessed by the Hamilton Rating Scale for Depression (HRSD) and the Clinical Global Impression Scale. Results: BDNF plasma levels were significantly lower in the patients with the severest illness compared with the others, and the same was true for patients with dissociative symptoms, severe sleep disturbance and recurrent depression. A significant and negative correlation was observed between the biological parameter and the retardation factor score of the HRSD. Conclusion: These findings suggest that low BDNF levels are related to both recurrence and severity of depression, as well as to symptoms typical of dysfunctions of the hypothalamic-pituitary-adrenal axis.

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Section: Discussionmentioning

confidence: 99%

Associations between Brain-Derived Neurotrophic Factor Plasma Levels and Severity of the Illness, Recurrence and Symptoms in Depressed Patients

et al. 2010

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“…[34,[90][91][92][93] Given that a failure in the central NE regulation of HPA activity and the subsequent inability to regulate the stress response can contribute to the pathogenesis of mood and anxiety symptoms, the neuroplastic changes after antidepressant treatments suggest that NE and/or 5-HT can have a direct role in regulating BDNF expression, and a disruption of NE and/or 5-HT functions in the brain can contribute to the cellular mechanisms underlying anxiety and depression. [34,[91][92][93][94][95][96][97] Furthermore, nonpharmacological approaches (e.g., exercise, diet control, and life-style changes) also increase BDNF and neurogenesis. [78,[98][99][100] These approaches may constitute an indirect way to modulate NE functions, which, in turn, regulate BDNF and neurogenesis-dependent mechanisms to normalize the state of anxious depression.…”

Section: Stress Ne Brain-derived Neurotrophic Factor and Adult Neurmentioning

confidence: 99%

Current perspectives of the roles of the central norepinephrine system in anxiety and depression

et al. 2010

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Norepinephrine (NE) is a major monoamine neurotransmitter that has widespread effects across multiple brain areas to regulate arousal and stress responses. The underlying function of the NE cortical system is to balance vigilance/scanning behavior with focused attention on novel environmental stimuli and the state of arousal. The central NE system is involved intrinsically with the stress response system, and dysregulation within the NE system has been implicated in the pathogenesis of anxiety and depressive disorders. Central NE activity paradoxically has either anxiogenic or anxiolytic effects, depending on whether the time course of the stress is acute or chronic, whether the stress is predictable or unpredictable, and which underlying brain regions are affected. Under conditions of chronic stress, NE system activity dysregulation of the hypothalamic-pituitary-adrenal system may turn a homeostatic stress response into a pathological stress response. Data suggest that the NE interplay with the serotonin system may exert neurobiological normalization of the pathophysiological state of anxious depression. Accordingly, pharmacological interventions targeting the NE system can result in anxiolytic, rather than anxiogenic, outcomes when used to treat patients with anxiety and depression. Depression and Anxiety 27:339-350, 2010. r r

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“…The effect on NA and 5-HT uptake resulting from the acute and chronic administration of some drugs depends on the time of administration (Mannari et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Acute effects of restraint, shock and training in the elevated T-Maze on noradrenaline and serotonin systems of the prefrontal cortex.

García-Saldívar

González-López

Monroy

et al. 2014

Acta. Colomb. Psicol.

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The prefrontal cortex (PFC) participates in cognitive functions and stress regulation. Noradrenaline (NA) and serotonin (5-HT) levels in some regions of the central nervous system are modified by acute stress. The effects depend on the type of stressor and the time elapsed between the presence of the stressor and the assessment. The aims of the present study were to assess the acute effect of different stressors on NA and 5-HT activities in the PFC and its relation with corticosterone levels. Independent groups of male Wistar rats (250-280 g) were submitted to restraint, footshock or training in the elevated T-maze (ETMT). The animals were sacrificed immediately (T0) or one hour (T1) after stress exposure. An untreated group sacrificed concurrently with treated animals was included as control. Samples of the PFC were dissected and the concentration of NA, 5-HT and their metabolites were measured by HPLC. Corticosterone levels were measured in serum. None of the treatments modified NA levels in the PFC. Animals exposed to footshock or ETMT showed significantly higher concentrations of 5-HT at T0. Restraint and footshock treatments were associated with higher corticosterone levels at T0 and T1 after the respective treatment. Taken together the results show that in the PFC, the noradrenergic and serotonergic systems, and the corticosterone levels respond in different ways to different stressors. Key words: Stressors, noradrenaline, serotonin, prefrontal cortex, corticosterona. EFECTOS AGUDOS DE LA RESTRICCIÓN, CHOQUE Y ENTRENAMIENTO EN EL LABERINTO ELEVADO EN T EN LOS SISTEMAS DE NORADRENALINA Y SEROTONINA EN LA CORTEZA PREFRONTAL ResumenLa corteza prefrontal (CPF) participa en las funciones cognitivas y la regulación del estrés. Las concentraciones de noradrenalina (NA) y serotonina (5-HT) en algunas regiones en el sistema nervioso central son modificadas por el estrés agudo. El efecto depende del estresor y del tiempo que transcurra entre el estresor y la evaluación. El objetivo del presente estudio fue evaluar el efecto agudo de diferentes estresores en la actividad de la NA y 5-HT en la CPF y su relación con los niveles de corticosterona. Grupos independientes de ratas (250-270 g) fueron sometidos a restricción, choque o entrenamiento en el laberinto elevado en T (ELET). Los animales fueron sacrificados inmediatamente (T0) o una hora (T1) después de la exposición al estrés. Un grupo no tratado, sacrificado al mismo tiempo que los animales tratados, se incluyó como control. Las muestras de la CPF fueron disecadas y la concentración de NA, 5-HT y sus metabolitos fue detectada por la técnica de HPLC. Las concentraciones de corticosterona fueron medidas en el suero. Ninguno de los tratamientos modificó las concentraciones de NA en la CPF. Al T0 los animales expuestos a choque o al ELET mostraron concentraciones de 5-HT significativamente mayores que el control. Los tratamientos de restricción y choque estuvieron asociados con altas concentraciones de corticosterona al T0 y a T1 después del tratamiento respe...

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BDNF Level in the Rat Prefrontal Cortex Increases Following Chronic but Not Acute Treatment with Duloxetine, a Dual Acting Inhibitor of Noradrenaline and Serotonin Re-uptake

Abstract: Our results show a major finding that repeated, but not single, Duloxetine treatment increases the level of BDNF in the prefrontal cortex.

Cited by 56 publications

References 78 publications

Associations between Brain-Derived Neurotrophic Factor Plasma Levels and Severity of the Illness, Recurrence and Symptoms in Depressed Patients

Associations between Brain-Derived Neurotrophic Factor Plasma Levels and Severity of the Illness, Recurrence and Symptoms in Depressed Patients

Current perspectives of the roles of the central norepinephrine system in anxiety and depression

Acute effects of restraint, shock and training in the elevated T-Maze on noradrenaline and serotonin systems of the prefrontal cortex.

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