BDNF gene and obsessive compulsive disorder risk, symptom dimensions and treatment response

J, Reshma Jabeen Taj M; Ganesh, Suhas; Shukla, Tulika; Deolankar, Sayali Chandrashekhar; Nadella, Ravi Kumar; Sen, Somdatta; Purushottam, Meera; Reddy, Y.C. Janardhan; Jain, Sanjeev; Viswanath, Biju

doi:10.1016/j.ajp.2017.10.014

Cited by 30 publications

(11 citation statements)

References 35 publications

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“…Our finding is consistent with the European population (De Luca et al, 2008; Frazier et al, 2014; Li et al, 2016), which indicate a positive association of the Val allele with BD risk. In the current study, the genotype and allele frequency of control subjects are similar to other reports from our group (Taj M J et al, 2017; Timothy, 2017, unpublished data (doctoral thesis)).…”

Section: Discussionsupporting

confidence: 91%

Association study of BDNF Val66Met gene polymorphism with bipolar disorder and lithium treatment response in Indian population

Paul

Nadella

Sen

et al. 2020

Preprint

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Background: The association of the Val66Met (rs6265) polymorphism in the brain derived neurotrophic factor (BDNF) gene with bipolar disorder (BD) and response to lithium treatment has been suggested, though inconsistently. The considerable diversity of allele frequency across different populations contributes to this. There is no data from South Asia till date. Hence, we examined the association of this polymorphism in BD cases from India, and its correlation with lithium treatment response. Methods: BD patients (N=301) were recruited from the clinical services of National Institute of Mental Health and Neurosciences (NIMHANS), India. Lithium treatment response for 190 BD subjects was assessed using Alda scale by NIMH life charts. Patients with total score ≥ 7 were defined as lithium responders (N=115) and patients with score <7 were defined as lithium non-responders (N=75). Healthy controls (N = 484) with no lifetime history of neuropsychiatric illness, or a family history of mental illness were recruited as control set. Genotyping was performed by TaqMan genotyping assay. Results: Genotype and allele frequency of BDNF Val66Met SNP was significantly different (χ2 = 7.78, p=0.02) in cases compared to controls, and the Val(G) allele was more frequent (χ2 = 7.08, p=0.008) in BD patients. Although there was trend towards significance for greater occurrence of Val(G) allele among lithium non-responders, this difference did not persist in an analysis of extreme response groups. Conclusions: The Val(G) allele of BDNF Val66Met polymorphism is associated with risk of BD in this sample, but is not related to response to lithium.

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Section: Discussionsupporting

confidence: 91%

Association study of BDNF Val66Met gene polymorphism with bipolar disorder and lithium treatment response in Indian population

Paul

Nadella

Sen

et al. 2020

Preprint

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“…Besides, a study on the Mexican population showed that there was a significantly higher frequency of Val/Val genotype and Val allele in OCD subjects as compared with the control group (Márquez et al, 2013). A similar result pattern was reported in South Indian population whereby a higher frequency of the Met allele was observed among controls as compared to cases, indicating a possible protective effect of the Met variant against the development of the disorder (Taj M J et al, 2017). Despite the availability of studies with a positive association of the BDNF variant to OCD, some studies found negative results.…”

Section: Obsessive-compulsive Disorder (Ocd)supporting

confidence: 66%

Single nucleotide polymorphism of BDNF Val66Met (rs6265) and its association to neuropsychiatric disorders

2020

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Brain-derived neurotrophic factor (BDNF) is the most abundant neurotrophin in the central nervous system and was shown to be involved in neuronal growth, differentiation and synaptic plasticity. A single nucleotide polymorphism at the pro-region of the BDNF gene (rs6265) has been reported to alter the amino acid from valine to methionine at codon 66 and was associated with neuropsychiatric disorders in several studies. To date, the results on the association of BDNF rs6265 to the aetiology of the neuropsychiatric illnesses have been inconsistent with some studies reporting a positive association and others reporting no association. Concerning the past inconsistent reports, this mini-review aims at determining the association of BDNF rs6265 and neuropsychiatric disorders among the different studies. Firstly, we discuss the findings on studies reporting the association of BDNF rs6265 with depression whereby a positive association between the BDNF variant and depression was obtained in several studies on the Caucasian, German, Chinese, and Malaysian population but not in studies on the Korean and other populations. Likewise, some studies found the occurrence of the SNP to be associated with a reduction in the BDNF level in depressed cases, but others found no effect at all. We then reported findings on the association of BDNF rs6265 with anxiety disorder, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, bipolar disorder, and schizophrenia. Val allele has been found associated with these disorders, whereas some studies reported the involvement of the Met allele, and some reported no association at all. Similarly, the association of the BDNF variant with the BDNF level remains controversial. It is, therefore, essential to conduct more studies with larger sample sizes and look at the haplotype level to determine the association.

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“…Previous studies have found that familial OCD is also associated with more compulsions, greater severity of illness and greater comorbidity (Arumugham et al, 2014;Viswanath et al, 2011). The other characteristics of the sample (symptoms, comorbidity, treatment response) are as in other OCD studies from our center (Taj M J et al, 2018(Taj M J et al, , 2013.…”

Section: Discussionmentioning

confidence: 80%

Association of SAPAP3 allelic variants with symptom dimensions and pharmacological treatment response in obsessive–compulsive disorder.

Naaz¹,

Balachander²,

Murthy³

et al. 2022

Experimental and Clinical Psychopharmacology

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BDNF gene and obsessive compulsive disorder risk, symptom dimensions and treatment response

Cited by 30 publications

References 35 publications

Association study of BDNF Val66Met gene polymorphism with bipolar disorder and lithium treatment response in Indian population

Association study of BDNF Val66Met gene polymorphism with bipolar disorder and lithium treatment response in Indian population

Single nucleotide polymorphism of BDNF Val66Met (rs6265) and its association to neuropsychiatric disorders

Association of SAPAP3 allelic variants with symptom dimensions and pharmacological treatment response in obsessive–compulsive disorder.

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