BCR/ABL analysis in myelodysplastic syndromes

Ghalesardi, Omid Kiani; Far, Mohammad Ali Jalali; Khodadi, Elahe; Ahmadzadeh, Ahmad; Saki, Najmaldin

doi:10.1007/s00580-017-2602-4

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…Cytogenetic abnormalities such as ampli cations, deletions, and translocations have been detected in about 50% of patients with de novo MDS and 80% of patients with secondary MDS, as well (7). Evaluation of cytogenetic abnormalities is useful in the diagnosis of MDS and crucial in determining the prognosis (8). Indeed, the chromosomal abnormality type is one of the most important factors employed in the MDS Revised International Prognostic Scoring System (R-IPSS) (9).…”

Section: Diagnosis Of Mds Transpires Via Scrutiny Of the Peripheral Bmentioning

confidence: 99%

Clinico-Hematological and cytogenetic spectrum of adult myelodysplastic syndrome The first retrospective cross-sectional study in Iranian patients

Paridar

Zibara

Ahmadi

et al. 2021

Preprint

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Background Myelodysplastic syndrome (MDS), a heterogeneous group of hematopoietic malignancy, has been shown to present different cytogenetic abnormalities, risk factors, and clinico-hematological features in different populations and geographic areas. Herein, we determined the cytogenetic spectrum and clinico-hematological features of Iranian MDS patients for the first time. Methods This prospective cross-sectional study was conducted on 103 patients with MDS in Ahvaz, southwest of Iran, from 2014 to 2018. Clinical presentations, complete blood counts (CBC), and bone marrow (BM) biopsy samples were assessed. Perls' staining was used to evaluate BM iron storage. The cytogenetic evaluation was performed using the conventional G banding method on the BM. Results Patients’ median age was 62.3 (ranged from 50–76), and the majority were male (72.8%). The most common clinical symptom at the time of admission was fatigue (n = 33) followed by pallor (n = 27). The most common subgroup was MDS-Multi Lineage Dysplasia (MDS-MLD) (n = 38, 36.8%), followed by MDS-Single Lineage Dysplasia (MDS-SLD) (n = 28, 18.4%). A normal karyotype was observed in 59 patients (57.3%), while 44 patients (42.7%) had cytogenetic abnormalities. Trisomy 8 (+ 8) was the most common cytogenetic abnormality (n = 14) followed by dell 17p (n = 9) and monosomy 7 (-7) (n = 7). Twelve patients (11.65 %) were transformed to AML. Conclusion Our data betokened that among our MDS patients, Trisomy 8 is the predominant cytogenetic abnormality, and MDS-MLD and MDS-SLD are the most common of subtypes. Noteworthy, the male: female ratio was slightly higher in Iran than in previous reports from other parts of the world. Our study is the first report of the clinical, hematological, and cytogenetic spectrum of MDS patients in Iran

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Section: Diagnosis Of Mds Transpires Via Scrutiny Of the Peripheral Bmentioning

confidence: 99%

Clinico-Hematological and cytogenetic spectrum of adult myelodysplastic syndrome The first retrospective cross-sectional study in Iranian patients

Paridar

Zibara

Ahmadi

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Cytogenetic abnormalities such as amplifications, deletions, and translocations have been detected in about 50% of patients with de novo MDS and 80% of patients with secondary MDS, as well [ 7 ]. Evaluation of cytogenetic abnormalities is useful in the diagnosis of MDS and crucial in determining the prognosis [ 8 ]. Indeed, the chromosomal abnormality type is one of the most important factors employed in the MDS Revised International Prognostic Scoring System (R-IPSS) [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Clinico-Hematological and cytogenetic spectrum of adult myelodysplastic syndrome: The first retrospective cross-sectional study in Iranian patients

et al. 2021

View full text Add to dashboard Cite

Background Myelodysplastic syndrome (MDS), a heterogeneous group of hematopoietic malignancy, has been shown to present different cytogenetic abnormalities, risk factors, and clinico-hematological features in different populations and geographic areas. Herein, we determined the cytogenetic spectrum and clinico-hematological features of Iranian MDS patients for the first time. Methods This prospective cross-sectional study was conducted on 103 patients with MDS in Ahvaz, southwest of Iran, from 2014 to 2018. Clinical presentations, complete blood counts (CBC), and bone marrow (BM) biopsy samples were assessed. Perls' staining was used to evaluate BM iron storage. The cytogenetic evaluation was performed using the conventional G banding method on the BM. Results Patients’ median age was 62.3 (ranged from 50–76), and the majority were male (72.8%). The most common clinical symptom at the time of admission was fatigue (n = 33) followed by pallor (n = 27). The most common subgroup was MDS-Multi Lineage Dysplasia (MDS-MLD) (n = 38, 36.8%), followed by MDS-Single Lineage Dysplasia (MDS-SLD) (n = 28, 18.4%). A normal karyotype was observed in 59 patients (57.3%), while 44 patients (42.7%) had cytogenetic abnormalities. Trisomy 8 (+ 8) was the most common cytogenetic abnormality (n = 14) followed by del 17p (n = 9) and monosomy 7 (− 7) (n = 7). Twelve patients (11.65%) were transformed to AML. Conclusion Our data betokened that among our MDS patients, Trisomy 8 is the predominant cytogenetic abnormality, and MDS-MLD and MDS-SLD are the most common of subtypes. Noteworthy, the male: female ratio was slightly higher in Iran than in previous reports from other parts of the world. Our study is the first report of the clinical, hematological, and cytogenetic spectrum of MDS patients in Iran

show abstract

BCR/ABL analysis in myelodysplastic syndromes

Cited by 2 publications

References 17 publications

Clinico-Hematological and cytogenetic spectrum of adult myelodysplastic syndrome The first retrospective cross-sectional study in Iranian patients

Clinico-Hematological and cytogenetic spectrum of adult myelodysplastic syndrome The first retrospective cross-sectional study in Iranian patients

Clinico-Hematological and cytogenetic spectrum of adult myelodysplastic syndrome: The first retrospective cross-sectional study in Iranian patients

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