BCNU-loaded PEG–PLLA ultrafine fibers and their in vitro antitumor activity against Glioma C6 cells

Xu, Xiuling; Chen, Xuesi; Xu, Xiaoyi; Lu, Tiancheng; Wang, Xin; Yang, L.; Jing, Xiabin

doi:10.1016/j.jconrel.2006.05.031

Cited by 157 publications

(79 citation statements)

References 34 publications

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“…Recent work has examined the possibility of using electrospun matrices as constructs for giving controlled release of a number of drugs including antibiotics [95e97] and anticancer drugs [98,99]; as well as proteins [31,33,50,66] and DNA [66,90,100] for applications in tissue engineering ( Table 2). Following an invasive surgery in a region such as the abdominal wall, it is common to deliver antibiotics either systemically or locally in order to prevent infection at the surgery site.…”

Section: Drugs/drug Loadingmentioning

confidence: 99%

Electrospinning: Applications in drug delivery and tissue engineering

Sill¹,

Recum²

2008

Biomaterials

2,849

1,936

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Section: Drugs/drug Loadingmentioning

confidence: 99%

Electrospinning: Applications in drug delivery and tissue engineering

Sill¹,

Recum²

2008

Biomaterials

2,849

1,936

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“…Moreover, electrospinning process allows scaffold functionalization, by encapsulation of different bioactive agents, which can modulate the activity of seeded cells. A number of molecules can be delivered, including antibiotics, anticancer drugs, and proteins [12,13]. Bioactive nanoparticles dispersed in electrospun microfibers have demonstrated a capacity to modulate the differentiation of human mesenchymal stem cells (hMSCs) [11].…”

Section: Introductionmentioning

confidence: 99%

Bioactive electrospun scaffold for annulus fibrosus repair and regeneration

et al. 2012

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Purpose Annulus fibrosus (AF) tissue engineering is gathering increasing interest for the development of strategies to reduce recurrent disc herniation (DH) rate and to increase the effectiveness of intervertebral disc regeneration strategies. This study evaluates the use of a bioactive microfibrous poly(L-lactide) scaffold releasing Transforming Growth Factor (TGF)-b1 (PLLA/TGF) for the repair and regeneration of damaged AF. Methods The scaffold was synthesized by electrospinning, with a direct incorporation of TGF-b1 into the polymeric solution, and characterized in terms of morphology and drug release profile. Biological evaluation was performed with bovine AF cells (AFCs) that were cultured on the scaffold up to 3 weeks to quantitatively assess glycosaminoglycans and total collagen production, using bare electrospun PLLA as a control. Histological evaluation was performed to determine the thickness of the deposited neo-ECM. Results Results demonstrated that AFCs cultured on PLLA/TGF deposited a significantly greater amount of glycosaminoglycans and total collagen than the control, with higher neo-ECM thickness. Conclusions PLLA/TGF scaffold induced an anabolic stimulus on AFCs, mimicking the ECM three-dimensional environment of AF tissue. This bioactive scaffold showed encouraging results that allow envisaging an application for AF tissue engineering strategies and AF repair after discectomy for the prevention of recurrent DH.

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“…It showed that the drug release behavior was able to be controlled by adjusting the loaded drug amount. Xu et al (20) also discovered a similar phenomenon when they investigated the in vitro release of BCNU-loaded PEG-PLLA ultra-fine fibers. Fig.…”

Section: Resultsmentioning

confidence: 64%

Preparation of a composite fibrous membrane loaded with mesalazine and metronidazole by interlaced electrospinning

Wang

Suo

2011

Mol Med Report

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Abstract. Novel composite fibrous membranes loaded with mesalazine and metronidazole were fabricated via interlaced electrospinning. The fibers were characterized by scanning electron microscopy and FTIR transmission spectra techniques. These characterizations were performed in the aim of optimizing the experimental conditions which allowed us to obtain good morphology of fibrous membrane loaded drugs. The in vitro release experiments revealed that mesalazine and metronidazole were released continuously from the loaded drug fibrous membrane. The fibrous membrane-loaded drugs also showed excellent stability. Compared to those of other drug delivery systems, the main advantage of these two fibrous membrane-loaded drugs is that they can be directly implanted as a lesion after surgery to inhibit recurrence in Crohn's disease.

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BCNU-loaded PEG–PLLA ultrafine fibers and their in vitro antitumor activity against Glioma C6 cells

Cited by 157 publications

References 34 publications

Electrospinning: Applications in drug delivery and tissue engineering

Electrospinning: Applications in drug delivery and tissue engineering

Bioactive electrospun scaffold for annulus fibrosus repair and regeneration

Preparation of a composite fibrous membrane loaded with mesalazine and metronidazole by interlaced electrospinning

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