BCL2-Negative Follicular Lymphoma of the Uterine Cervix: A Case Report and Literature Review

Abstract

Lymphoma involving the female genital tract is rare and the uterine cervix is an uncommon site for lymphoma. Follicular lymphoma is the second most common Non-Hodgkin's lymphoma involving the uterine cervix. The t(14;18)(q32;q21) chromosome abnormality is the genetic hallmark of Follicular lymphoma and can be detected in about 80% of Follicular lymphoma involving the gynecologic tract. The t(14;18)(q32;q21) negative follicular lymphoma is unusual and may cause confusion for the pathologist not familiar with its clinical, histologic and immunohistochemical features. This case report intends to create awareness of this rare clinical entity. Lymphoma should be included in the differential diagnosis of gynecologic malignancies.