BCL11A expression in acute myeloid leukemia

Tao, Huiquan; Ma, Xiao; Su, Guanghao; Yin, Jiawei; Xie, Xiaoli; Hu, Chenxi; Zheng, Chen; Tan, Dongming; Xu, Zhongjuan; Zheng, Yuanna; Liu, Hong; He, Chao; Mao, Zhuo; Yin, Hongchao; Wang, Zhiwei; Chang, Weirong; Gale, Robert Peter; Chen, Zixing; Wu, Depei; Yin, Bin

doi:10.1016/j.leukres.2015.12.001

Cited by 16 publications

(21 citation statements)

References 36 publications

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“…Additionally, BCL11A is related to the development of B cell malignancies, in which it is expressed at high levels (26). BCL11A is upregulated by FOXQ1 overexpression in colorectal cancer and acute myeloid leukemia (21,27).…”

Section: Inhibition Of Foxq1 Induces Apoptosis and Suppresses Prolifementioning

confidence: 99%

Inhibition of FOXQ1 induces apoptosis and suppresses proliferation in prostate cancer cells by controlling BCL11A/MDM2 expression

Zhang

Wang

et al. 2016

Oncology Reports

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Forkhead box Q1 (FOXQ1) has been recognized as an oncogene that is overexpressed in different cancers, and several studies have shown that FOXQ1 is related to apoptosis and proliferation in many cancer types. However, the role and the molecular mechanism of FOXQ1 in prostate cancer remains unclear. In this study, we aimed to explore the role of FOXQ1 in regulating cell apoptosis, proliferation and invasion in prostate cancer and the underlying mechanism. We found that FOXQ1 was highly expressed in the prostate cancer tissues and cell lines. In our FOXQ1 loss-of-function experiments, the data indicate that the expression of BCL11A and MDM2 was significantly downregulated, prostate cancer cell proliferation and invasion were markedly suppressed, and apoptosis was significantly induced. Moreover, overexpression of BCL11A obviously reversed the effect of FOXQ1 inhibition on apoptosis, proliferation and invasion of prostate cancer cells. In addition, BCL11A overexpression also abrogated the inhibitory effect of FOXQ1 suppression on MDM2 expression. Taken together, our study suggests that FOXQ1 regulates prostate cancer cell proliferation and apoptosis by regulating BCL11A/MDM2 expression and indicates that FOXQ1 may serve as a potential therapeutic target for prostate cancer.

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Section: Inhibition Of Foxq1 Induces Apoptosis and Suppresses Prolifementioning

confidence: 99%

Inhibition of FOXQ1 induces apoptosis and suppresses proliferation in prostate cancer cells by controlling BCL11A/MDM2 expression

Zhang

Wang

et al. 2016

Oncology Reports

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“…While, no significant correlation was detected between complete remission rate and survival. These data indicate that BCL11A expression possibly plays role in AML [1].…”

Section: Methodsmentioning

confidence: 59%

“…Acute myeloid leukemia (AML) is an invasive hematological cancer that affects different clonal hematopoietic cells leading to distinct differences in their response to chemotherapy treatment [1]. Despite advancement in leukemia therapy, the mortality rate remains high as a result of disease progression.…”

Section: Introductionmentioning

confidence: 99%

Proteomic profile of acute myeloid leukaemia: A review update

Almaiman¹,

Abdullah²,

Abdul³

et al. 2016

Trop. J. Pharm Res

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“…The Bcl11a transcription factor is also aberrantly‐expressed in some persons with acute myeloid leukemia, and increased in subjects with chronic myeloid leukemia in acute phase compared with those in normal and in subjects in chronic phase including some subjects studied in both phases . Our previous study also showed the expression levels of Bcl11a in B CLL and B‐cell lymphoma was significantly higher than those in the healthy control .…”

Section: Introductionmentioning

confidence: 77%

“…A recent study showed significant associations between levels of Bcl11a expression and clinical and laboratory variables in persons with newly‐diagnosed acute myeloid leukemia. But, there were nonsignificant associations with CR rate and survival . The study of Yin et al .…”

Section: Discussionmentioning

confidence: 93%

The expression pattern of Bcl11a, Mdm2 and Pten genes in B‐cell acute lymphoblastic leukemia

et al. 2017

Asia-Pac J Clncl Oncology

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BCL11A expression in acute myeloid leukemia

Cited by 16 publications

References 36 publications

Inhibition of FOXQ1 induces apoptosis and suppresses proliferation in prostate cancer cells by controlling BCL11A/MDM2 expression

Inhibition of FOXQ1 induces apoptosis and suppresses proliferation in prostate cancer cells by controlling BCL11A/MDM2 expression

Proteomic profile of acute myeloid leukaemia: A review update

The expression pattern of Bcl11a, Mdm2 and Pten genes in B‐cell acute lymphoblastic leukemia

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