Bcl11 Transcription Factors Regulate Cortical Development and Function

Simon, Ralph; Wiegreffe, Christoph; Britsch, Stefan

doi:10.3389/fnmol.2020.00051

Cited by 44 publications

(44 citation statements)

References 116 publications

(186 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Conditional gene inactivation of Bcl11a in mDA neurons results in a rostral-to-caudal shift of Bcl11a-mDA neurons from the VTA to the CLi Since BCL11A is a transcription factor that has been shown to influence neuronal fate, neuronal morphology and migration (Simon et al, 2020), we investigated whether BCL11A is necessary for establishing and/or maintaining Bcl11a-expressing mDA neurons and their cell fate as well as their particular projection pattern. We generated a specific knock-out for Bcl11a in mDA neurons by crossing Bcl11a flox mice with Dat IRES-Cre mice (Bcl11a cko flox ; Genotype:…”

Section: Bcl11a-expressing Mda Neurons Form a Subcircuit In The Dopammentioning

confidence: 99%

“…BCL11A is a zinc finger transcription factor that acts mainly as a repressor but it is also part of an ATP dependent chromatin remodeling complex in neural tissue. Bcl11a is expressed in many types of neurons in almost every region of the CNS (Allen Brain Atlas), but its molecular function has only been studied in a few regions so far (Simon et al, 2020). In the cortex, BCL11A is important for the specification of cortical neurons that project to subcerebral areas (Canovas et al, 2015;Woodworth et al, 2016) and it controls the acquisition of sensory area identity and the establishment of sensory input fields (Greig et al, 2016).…”

Section: Function Of Bcl11a In Developing and Mature Mda Neuronsmentioning

confidence: 99%

“…We discovered that the C2H2 zinc finger transcription factor BCL11A (B cell CLL/lymphoma) is expressed in a subpopulation of mDA neurons from embryogenesis to adulthood. BCL11A, also known as CTIP1 (Chicken ovalbumin upstream promoter transcription factor-interacting proteins 1), is a transcriptional repressor and a dedicated subunit of the mammalian SWI/SNF complex, a polymorphic assembly of at least 14 subunits (encoded by 28 genes) that functions as an ATP-dependent chromatin remodeler (Kadoch et al, 2013;Simon et al, 2020). In the mouse, BCL11A regulates neuronal fate determination during cortex and spinal cord development (Simon et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…BCL11A, also known as CTIP1 (Chicken ovalbumin upstream promoter transcription factor-interacting proteins 1), is a transcriptional repressor and a dedicated subunit of the mammalian SWI/SNF complex, a polymorphic assembly of at least 14 subunits (encoded by 28 genes) that functions as an ATP-dependent chromatin remodeler (Kadoch et al, 2013;Simon et al, 2020). In the mouse, BCL11A regulates neuronal fate determination during cortex and spinal cord development (Simon et al, 2020). In humans, BCL11A haploinsufficiency results in neurodevelopmental disorders characterized by developmental delay, mild to severe intellectual disability and behavioral problems (Basak et al, 2015;Deciphering Developmental Disorders Study, 2015;Dias et al, 2016;Peron et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The transcription factor BCL11A defines a distinctive subset of dopamine neurons in the developing and adult midbrain

Tolve

Ulusoy

Islam

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Midbrain dopaminergic (mDA) neurons are diverse in their projection targets, impact on behavior and susceptibility to neurodegeneration. Little is known about the molecular mechanisms that establish this diversity in mDA neurons during development. We find that the transcription factor Bcl11a defines a subset of mDA neurons in the developing and adult murine brain. By combining intersectional labeling and viral-mediated tracing we show that Bcl11a-expressing mDA neurons form a highly specific subcircuit within the dopaminergic system. We demonstrate that Bcl11a-expressing mDA neurons in the substantia nigra (SN) are particularly vulnerable to neurodegeneration in an α-synuclein overexpression model of Parkinson’s disease. Inactivation of Bcl11a in developing mDA neurons results in anatomical changes, deficits in motor learning and a dramatic increase in the susceptibility to α-synuclein-induced degeneration in SN-mDA neurons. In summary, we identify an mDA subpopulation with highly distinctive characteristics defined by the expression of the transcription factor Bcl11a already during development.

show abstract

Section: Bcl11a-expressing Mda Neurons Form a Subcircuit In The Dopammentioning

confidence: 99%

Section: Function Of Bcl11a In Developing and Mature Mda Neuronsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The transcription factor BCL11A defines a distinctive subset of dopamine neurons in the developing and adult midbrain

Tolve

Ulusoy

Islam

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…We discuss also data from recent genome-wide association studies (GWAS) that suggest to some extent a potential influence for this gene in modulating the occurrence of cardiovascular disease. The function of Bcl11b in T cell biology and the brain is largely covered by numerous reviews ( Liu et al, 2010 ; Avram and Califano, 2014 ; Lennon et al, 2017 ; Rothenberg, 2019 ; Simon et al, 2020 ) and is presented only briefly in the present review.…”

Section: Introductionmentioning

confidence: 99%

Bcl11b/Ctip2 in Skin, Tooth, and Craniofacial System

Daher

Bausero

Agbulut

et al. 2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Ctip2/Bcl11b is a zinc finger transcription factor with dual action (repression/activation) that couples epigenetic regulation to gene transcription during the development of various tissues. It is involved in a variety of physiological responses under healthy and pathological conditions. Its role and mechanisms of action are best characterized in the immune and nervous systems. Furthermore, its implication in the development and homeostasis of other various tissues has also been reported. In the present review, we describe its role in skin development, adipogenesis, tooth formation and cranial suture ossification. Experimental data from several studies demonstrate the involvement of Bcl11b in the control of the balance between cell proliferation and differentiation during organ formation and repair, and more specifically in the context of stem cell self-renewal and fate determination. The impact of mutations in the coding sequences of Bcl11b on the development of diseases such as craniosynostosis is also presented. Finally, we discuss genome-wide association studies that suggest a potential influence of single nucleotide polymorphisms found in the 3’ regulatory region of Bcl11b on the homeostasis of the cardiovascular system.

show abstract

Corticogenesis across species at single‐cell resolution

Park

Ortiz

Konopka

2022

Developmental Neurobiology

View full text Add to dashboard Cite

The neocortex (or pallium) consists of diverse cell types that are organized in a highly species‐specific manner under strict spatiotemporal control during development. Many of the cell types are present transiently throughout development but contribute to permanent species‐specific cortical features that are acquired through evolution. Therefore, capturing cell type‐specific biological information has always been an important quest in the field of neurodevelopment. The progress in achieving fine cellular resolution has been slow due to technical challenges. However, with recent advancements in single‐cell and multi‐omics technologies, many laboratories have begun to successfully interrogate cellular and molecular mechanisms driving corticogenesis at single‐cell resolution. In this review, we provide summarized results from many primary publications and several in‐depth review articles that utilize or address single‐cell genomics techniques to understand important topics, such as cellular and molecular mechanisms governing cortical progenitor proliferation, cell lineage progression, neuronal specification, and arealization, across multiple gyrencephalic (i.e., human and non‐human primates) and lissencephalic species (i.e., mouse, reptiles, and songbirds). We also examine findings from recent studies involving epigenomic and posttranscriptional regulation of corticogenesis. In the discussion section, we provide our insights on the challenges the field currently faces as well as promising future applications of single cell technologies.

show abstract

Bcl11 Transcription Factors Regulate Cortical Development and Function

Cited by 44 publications

References 116 publications

The transcription factor BCL11A defines a distinctive subset of dopamine neurons in the developing and adult midbrain

The transcription factor BCL11A defines a distinctive subset of dopamine neurons in the developing and adult midbrain

Bcl11b/Ctip2 in Skin, Tooth, and Craniofacial System

Corticogenesis across species at single‐cell resolution

Contact Info

Product

Resources

About