Abstract:Adoptive immunotherapy using T cells has produced some encouraging clinical responses, but deficiencies resulting from a frequent lack of tumor specificity and poor survival of these cells has limited the widespread application of this approach. We used a chimeric receptor gene specific for erbB2 in T cells with genetic resistance to apoptosis to address these deficiencies. Expression of the chimeric receptor was found to be equivalent in T cells from bcl-2 transgenic-, lpr-and wild-type C57BL/6 mice. Furtherm… Show more
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