Bcl‐2 expression on fine‐needle aspirates from primary breast carcinoma

Abstract

Bcl-2 expression, evaluated by immunocytochemistry on FNAs from primary breast carcinoma, correlates with favorable prognostic features such as ER and PgR expression, p53 negativity, a low Ki-67 index, and high tumor differentiation. These results are in agreement with those found on histologic samples. As FNA biopsy is used increasingly as a primary tool in the diagnosis of breast carcinoma, Bcl-2 evaluation by immunocytochemistry on FNA may provide, in addition to other biologic variables, useful information for prognostic and predictive purposes, particularly in patients considered to be candidates for neoadjuvant treatments. Cancer (Cancer Cytopathol)

High expression of Ki-67 and cyclin D1 in invasive extramammary Paget's disease

“…In our study, we found no association between the invasive lesions of EMPD and p53 expression. In addtion, a previous study revealed that Bcl-2 expression was only seen at a low incidence in EMPD [29] compared with breast carcinomas [30,31]. Also in the present…”

Molecular markers in Paget disease of the breast

“…Overexpression has been shown to prevent or delay apoptosis induced by g-irradiation, growth factor deprivation, glucocorticoids, and various chemotherapeutic agents. Bcl-2 has been detected in 46±76% [46±48] of breast carcinomas, and its presence has been associated with other favorable prognostic factors such as ER and PR expression, a low Ki-67 index, p53 and Her-2/neu negativity [28,49], and low histologic tumor grade [48]. It is present in normal breast epithelium and may be an estrogen-related protein that is involved in the glandular cell renewal system of the breast [49].…”

p53 and breast cancer, an update

“…On the other hand, the expression of BCL2, MDM2, MDM4, PTEN and USP7 has been associated with the 'luminal-like' phenotype of breast cancer cells (BCC) and/or tumours (Bozzetti et al 1999, Kappes et al 2001, Phelps et al 2003, Garcia et al 2004, Lacroix et al 2004, Charafe-Jauffret et al 2006.…”