bcl‐2 EXPRESSION IN PLEURAL AND EXTRAPLEURAL SOLITARY FIBROUS TUMOURS

Chilosi, Marco; Facchetti, Fabio; Tos, Angelo Paolo Dei; Lestani, Maurizio; Morassi, Maria Laura; Martignoni, Guido; Sorio, Claudio; Benedetti, A.; Morelli, Luca; Doglioni, Claudio; Barberis, Massimo; Menestrina, Fabio; Viale, Giuseppe

doi:10.1002/(sici)1096-9896(199704)181:4<362::aid-path764>3.3.co;2-p

Cited by 39 publications

(44 citation statements)

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“…Uniquely in this anatomic site, SFT reacts with vimentin, CD34, bcl-2, and CD99. The combination of bcl-2 and CD34 has been reported to be consistently identified in SFT, a finding helpful in establishing the diagnosis [18,19]. CD34 is a cell adhesion transmembrane glycoprotein found on the surface of many cells, showing myofibroblastic differentiation, hematologic progenitor cells, vascular endothelium, and dendritic cells.…”

Section: Discussionmentioning

confidence: 96%

Solitary Fibrous Tumor of the Larynx

Thompson

Karamurzin

et al. 2008

Head and Neck Pathol

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Section: Discussionmentioning

confidence: 96%

Solitary Fibrous Tumor of the Larynx

Thompson

Karamurzin

et al. 2008

Head and Neck Pathol

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“…In fact, in the case series of Hanau [14], the percentage of Ki-67 positive nuclei was low in all benign SFTs with values of 0-2%, while histologically malignant and highly cellular tumours showed higher nuclear scores (mean 30%, range 20-40%). Chilosi et al [6] reported no proliferative potential in benign SFT, but no data were provided for malignant SFTs.…”

Section: Discussionmentioning

confidence: 99%

Solitary fibrous tumour of the adrenal gland associated with pregnancy

Bongiovanni¹,

Viberti²,

Giraudo

et al. 2000

Virchows Archiv

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Solitary fibrous tumour (SFT), first described as a pleural lesion, has been reported in several extrathoracic sites over the past 10 years. We describe a SFT of the left adrenal gland incidentally discovered in a 23-year-old, 22-week pregnant woman and characterised by a rapid growth during the third trimester of pregnancy. Elevated serum and urinary levels of cortisol and elevated blood levels of delta 4 androstendione and 17-OH progesterone were observed. After spontaneous delivery, the patient underwent laparoscopic resectioning of the mass and of the left adrenal gland from which the tumour was apparently originating. The kidney was not involved, and no other abdominal tumours were found. Histological and immunohistochemical features were typical of SFT of pleura and other locations. Only one case of adrenal SFT is on record, and the adrenal gland is to be added to the long list of extrathoracic locations of SFT. The association with pregnancy was a previously unrecognised event in SFT. The focal expression of progesterone receptors in the tumour cells may be related to pregnancy. This observation prompted an analysis of steroid hormone receptors in SFT of classical sites (pleura). Two of five cases had focal progesterone receptors too, a finding which deserves further investigations in a much larger series of SFTs.

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“…The reason for this extensive heterogeneity is presently unknown. This finding is also relevant since cdk6 is a kinase that is overexpressed in T-cell [2] and myeloid leukemias and its characterization could provide useful information on the complexity of cell cycle derangement occurring in these malignancies.…”

Section: -D Mapping Of Mantle Cell Lymphomamentioning

confidence: 99%

“…These findings suggest that the integrated analysis of the discrete array of molecules involved in the cell cycle regulation and the "p53 pathway" may provide relevant information regarding tumor response in vivo, and may supply clinically useful information at the single patient level. The analysis of the molecular repertoire of a neoplastic cell population can be practically obtained by different methodological approaches, including extensive immunophenotypical analysis of tissues sections, expression analysis by complex molecular array systems based on the measurement of mRNA expression levels in target cells, and also by proteome analysis [1][2][3][4]. All these approaches are potentially able to provide a large number of data, which can be related to different lymphoma entities and their clinical features.…”

Section: Introductionmentioning

confidence: 99%

Proteomics and immunomapping of reactive lymph-node and lymphoma

Antonucci¹,

Chilosi

Santacatterina

et al. 2002

Electrophoresis

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In the present study we show that two-dimensional (2-D) maps together with immuno-detection allow the precise identification of important leukocyte differentiation and tumor markers (e.g., CD3 and CD5), and important cell cycle regulatory molecules such as cyclin dependent kinases, notably CDK6. In addition, the comparative evaluation of molecular expression (e.g., CD5) in maps developed with normal and lymphoma samples can provide reproducible and precise information regarding the molecular expression in different cell populations. Accordingly, we could detect a much increased level of expression of CD5 in mantle cell lymphoma, up to ten times higher than in the control. In addition, CD5 in tumor tissues seems to be microheterogeneous as compared to normal samples.

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bcl‐2 EXPRESSION IN PLEURAL AND EXTRAPLEURAL SOLITARY FIBROUS TUMOURS

Cited by 39 publications

References 0 publications

Solitary Fibrous Tumor of the Larynx

Solitary Fibrous Tumor of the Larynx

Solitary fibrous tumour of the adrenal gland associated with pregnancy

Proteomics and immunomapping of reactive lymph-node and lymphoma

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