Abstract:Bacillus Calmette-Gu erin (BCG) has been given to more than three billion persons since its first use in 1921. The routine is to administer a single dose of the vaccine at, or soon after, birth in countries where tuberculosis (TB) is endemic. Most industrialized countries administer BCG to selected high-risk groups only.BCG constitutes a group of strains of live, attenuated Mycobacterium bovis. The parental strain was created in 1908 after serial subculture of the virulent bacterium over a period of 13 years. … Show more
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