BCG‐Induced cold abscess as a complication of inadvertent vaccine injection: A case series

Sedighi, Parinaz; Sadrosadat, Seyedeh Taravat; Movahedi, Mahsa; Sedighi, Iraj

doi:10.1002/ccr3.5711

Cited by 2 publications

(1 citation statement)

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“…Moreover, this case underscores the necessity for continuous monitoring of vaccine safety, especially given the global efforts to expand immunization programs [ 3 , 5 ]. The rarity of such complications necessitates collaboration among healthcare providers, researchers, and vaccine manufacturers to gather and analyze data systematically.…”

Section: Discussionmentioning

confidence: 99%

A Case Report of a Cold Chest Wall Abscess Following Bacillus Calmette-Guérin Vaccination

Hussain,

Rayyani,

Fatani

et al. 2024

Cureus

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The Bacillus Calmette-Guérin (BCG) vaccine, a cornerstone in global immunization programs for tuberculosis prevention, has generally proven to be safe and effective. However, rare complications, including localized abscess formation, have been reported. This case report highlights a two-year-old male who developed a painless swelling on the left chest wall, noticed six weeks post-BCG vaccination. Physical and imaging evaluations confirmed a cold abscess. Laboratory tests ruled out alternative diagnoses. Antitubercular therapy led to a favorable response, avoiding surgical intervention. Follow-up revealed complete resolution, showcasing successful management of this rare BCG-related complication in a pediatric patient. The success of antimycobacterial therapy supports a tailored and conservative approach, raising questions about the necessity of surgical intervention. The presented case sheds light on the complex interplay between BCG vaccination, host response, and rare complications, providing valuable insights for further research. Vigilance, robust surveillance, and collaborative efforts are essential to unravel vaccine-related adverse events. This case contributes to a deeper understanding of rare BCG-related complications, guiding clinical practice, and advancing the knowledge base.

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Section: Discussionmentioning

confidence: 99%