Bc-Prom

Hu, Xiaojuan; Zhang, Chunsen; Zhang, Yanbo

doi:10.1097/md.0000000000006781

Cited by 6 publications

(4 citation statements)

References 26 publications

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“…This study, therefore, focuses on trial recruitment and patient acceptability, considering the disease and treatment aspects that may influence adherence to the proposed intervention. To qualify a possible future trial, this study might be used to facilitate public and patient involvement [ 16 , 17 ].…”

Section: Methodsmentioning

confidence: 99%

The “home-based exercise for breast and prostate cancer patients during treatment—a feasibility trial” (BENEFIT CA trial): rationale and methodological protocol

da Silva,

Leite,

Ignacio

et al. 2023

Pilot Feasibility Stud

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Background Physical activity has been shown to benefit patients undergoing adjuvant cancer therapy. Although exercise interventions may be applied in several settings, most trials have focused on specialized facilities for their interventions. While these approaches benefit the access for individuals living near exercise centers, it hampers the assessment of real-world effectiveness. Therefore, evaluating the feasibility and implementation of home-based models of exercise training, especially in low-to-middle-income settings, may inform future physical activity trials and programs. In this article, we present the protocol for the BENEFIT CA trial, which aims to assess the implementation of a remote exercise intervention for patients with breast cancer or prostate cancer, primarily quantifying adherence to an exercise program. Methods This is a 12-week study, utilizing a non-randomized, single-arm design to assess the feasibility of a home-based exercise training. The intervention is remotely guided, and participants also receive an educational component about cancer and exercise. The study aims to recruit 40 patients diagnosed with breast cancer and 40 patients diagnosed with prostate cancer, all of whom undergoing active hormonal treatment. The primary outcome is the level of adherence, indicated as the proportion of performed exercise episodes. Secondary outcomes include recruitment rates, fatigue, quality of life, and functional capacity. Adverse events will be monitored throughout the study. Because this is a feasibility trial, the statistical analysis plan is based on descriptive statistics, which encompasses an intention-to-treat analysis and a plan for handling missing data. Discussion This is a low-cost feasibility study to orient the design of a wide-range, pragmatic phase 3 trial based on remote exercise intervention. With this study, we aim to better understand the adherence and implementation strategies regarding home-based exercise for the proposed population and, in the near future, move forward to a randomized clinical trial. In addition, this trial may contribute to engage patients with cancer in exercise programs throughout their treatment and beyond. Trial registration This trial has been approved by the Hospital de Clínicas de Porto Alegre Ethics Committee/IRB (48,869,621.9.0000.5327), and it is registered at Clinicaltrials.gov (NCT05258526), registered on February 25, 2022, prior to the beginning of the study.

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Section: Methodsmentioning

confidence: 99%

The “home-based exercise for breast and prostate cancer patients during treatment—a feasibility trial” (BENEFIT CA trial): rationale and methodological protocol

da Silva,

Leite,

Ignacio

et al. 2023

Pilot Feasibility Stud

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“…The Arabic version of the EORTC QLQ-C30 has previously been validated for BC patients. 14,18 The current study utilized the functional scale and global health subscales.…”

Section: Arabic Mcgill Quality Of Life Questionnaire-revisedmentioning

confidence: 99%

“…10,11 Consequently, there is a strong recommendation to develop and validate tools that can systematically incorporate HRQoL screening into oncology clinical practice and rehabilitation. [12][13][14] In response to this need, several patient-reported outcome measures (PROMs) have been validated in Arabic, such as the European Organization for Research and Treatment of Cancer (EORTC) Breast Cancer-Specific Quality of Life Questionnaire-23 item (QLQ-BR23), the Functional Assessment of Cancer Therapy-Breast (FACT-B), the EORTC Quality of Life Questionnaire, Version 3.0 (EORTC QLQ-C30), and the FACT-G. [15][16][17][18][19] However, these instruments are lengthy, primarily focus on physical characteristics and symptoms, and fail to consider existential or spiritual attributes. [20][21][22] Furthermore, these tools solely concentrate on the negative aspects of quality of life, despite both positive and negative factors influencing it.…”

Section: Introductionmentioning

confidence: 99%

Psychometric Properties and Factorial Analysis of the Arabic McGill-QoL Questionnaire in Breast Cancer

Omar,

Alnahdi

2023

BCTT

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This study aimed to assess the psychometric properties of the Arabic McGill Quality of Life Questionnaire-Revised (MQOL-R) in breast cancer survivors. Patients and Methods: One-hundred-forty breast cancer survivors were recruited and completed the questionnaire. The construct validity was assessed using confirmatory factor analysis (CFA). MQOL-R scores were correlated with Global Health Status/QoL and functional subscales of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) for convergent validity. Reliability was estimated using Cronbach's alpha and intraclass correlation coefficients (ICC). Results: CFA reproduced a four-factor model (ie, physical, psychological, existential, and social) with good fit indices (comparative fitting index = 0.980; root mean square error of approximation = 0.091), with all items significantly loading on their respective subscales. The total MQOL-R scores were correlated with the global health status/QoL and functional subscales of the EORTC QLQ-C30 (r = -0.172, P < 0.01). Known-group validity was proven by different MQOL-R scores according to functional status (50.62 ± 6.35 vs 45.98 ± 7.19, P < 0.01). Reliability was supported by good internal consistency and high test-retest correlation coefficients for the Arabic MQOL-R and its subscales (ICC range, 0.83-0.95). Conclusion:The Arabic MQOL-R demonstrated adequate construct validity, factor structure, excellent test-retest reliability, and good internal consistency. This tool is valuable for assessing the quality of life in research and physical therapy rehabilitation settings among Arabic-speaking breast cancer survivors.

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“…Although reports on coronavirus disease 2019 (COVID-19) affecting health already exceed 32 000 articles, studies on direct effects on the eye appear to be limited . Conjunctivitis, retinitis, episcleritis, and optic neuritis have all been described as ocular manifestations, but frequency and morbidity are fortunately not striking.…”

mentioning

confidence: 99%

2020 as the Year of Quarantine Myopia

2021

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Although reports on coronavirus disease 2019 affecting health already exceed 32 000 articles, studies on direct effects on the eye appear to be limited. 1 Conjunctivitis, retinitis, episcleritis, and optic neuritis have all been described as ocular manifestations, but frequency and morbidity are fortunately not striking. This has relieved us as ophthalmologists and given the impression that we have been spared a heavy patient load attributable to COVID-19 complications. We have focused on reorganizing our clinics and made sure that anti-vascular endothelial growth factor treatments and other urgent patient care were not obstructed.In this issue of JAMA Ophthalmology, Wang et al 2 are telling us another story. They suggest we should be worried about the ophthalmic outcome of COVID-19, not from the virus itself but from the potential outcome of an antivirus measure on eye health, specifically an outcome in children that may have major consequences for visual acuity later in life. China, followed by other Asian countries, was the first to experience the severe virus outbreak, the first to start closing schools and imposing home confinement, and the first (to our knowledge) to report the potential consequences of these actions on myopia. For the eye, this appears to be development of myopia at a young age; particularly, an early onset potentially increases the burden.What Wang et al 2 are reporting reflects an impressive scientific achievement. In China, a complete lockdown with home confinement took place from January to May, and schools reopened in June. During this 1 month, the examiners performed noncycloplegic photorefraction in schoolchildren aged 6 to 13 years; during the 3 months that followed, they analyzed all data and prepared for publication. The study was part of a yearly survey that started in 2015 and was in its totality truly big data (N = 123 535). A slight but potentially relevant omission is the number of children who participated each year, particularly this year. It is therefore unclear whether the number of participants in 2020 is the same as in other years, which would provide greater confidence of a fair comparison. Also, cycloplegic refractions are the gold standard in defining myopia in this age group.To assess temporal trends across age groups, the authors 2 calculated the mean spherical equivalent for each age at each year and estimated the prevalence of myopia. Overall, it is important to note the high proportion of myopia in these Asian children who are still in elementary school. At age 13 years, more than 80% already had myopia, while the prevalence at this age in European children is 25%. At all ages, mean refractive error involved greatest myopia in 2020, in girls even more so than boys. Most com-

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Bc-Prom

Abstract: Supplemental Digital Content is available in the text

Cited by 6 publications

References 26 publications

The “home-based exercise for breast and prostate cancer patients during treatment—a feasibility trial” (BENEFIT CA trial): rationale and methodological protocol

The “home-based exercise for breast and prostate cancer patients during treatment—a feasibility trial” (BENEFIT CA trial): rationale and methodological protocol

Psychometric Properties and Factorial Analysis of the Arabic McGill-QoL Questionnaire in Breast Cancer

2020 as the Year of Quarantine Myopia

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