BbWor1, a Regulator of Morphological Transition, Is Involved in Conidium-Hypha Switching, Blastospore Propagation, and Virulence in Beauveria bassiana

Qiu, Lei; Zhang, Tongsheng; Song, Ji-Zheng; Zhang, Jing; Li, Ze; Wang, Sheng

doi:10.1128/spectrum.00203-21

Cited by 5 publications

(5 citation statements)

References 49 publications

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“…Hyphae secrete hydrolases to strengthen the invasion and damage of C. albicans to the host, which is the key virulence factor [ 24 ]. We therefore examined the effect of MPD on filamentation under two hyphae-inducing media in vitro .…”

Section: Resultsmentioning

confidence: 99%

Inhibitory effects of a maleimide compound on the virulence factors of Candida albicans

Chen

Liu

et al. 2023

Virulence

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Candidiasis caused by Candida albicans infection has long been a serious human health problem. The pathogenicity of C. albicans is mainly due to its virulence factors, which are novel targets of antifungal drugs for low risk of resistance development. In this study, we identified a maleimide compound [1-(4-methoxyphenyl)-1hydro-pyrrole-2,5-dione, MPD] that exerts effective anti-virulence activity. It could inhibit the process of adhesion, filamentation, and biofilm formation in C. albicans . In addition, it exhibited low cytotoxicity, hemolytic activity, and drug resistance development. Moreover, in Galleria mellonella-C. albicans ( in vivo ) infection model, the survival time of infected larvae was significantly prolonged under the treatment of MPD. Further, mechanism research revealed that MPD increased farnesol secretion by upregulating the expression of Dpp3. The increased farnesol inhibited the activity of Cdc35, which then decreased the intracellular cAMP content resulting in the inhibition of virulence factors via the Ras1-cAMP-Efg1 pathway. In all, this study evaluated the inhibitory effect of MPD on various virulence factors of C. albicans and identified the underlying mechanisms. This suggests a potential application of MPD to overcome fungal infections in clinics.

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Section: Resultsmentioning

confidence: 99%

Inhibitory effects of a maleimide compound on the virulence factors of Candida albicans

Chen

Liu

et al. 2023

Virulence

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“…Conidia and hyphae are two cell morphologies of entomopathogenic fungi on host surface: conidia are propagules initiating pathogenesis and involved in disease transmission, and hyphae generations are critical to the invasion and virulence of the fungi. 52 A regulatory G protein-signalling gene, Bbrgs1, has been found to play an important role in regulating the switch between vegetative growth and conidiation of B. bassiana in response to specific environmental cue. 53 Morphological plasticity of pathogenetic fungi enhances their survival and virulence in specific host niches.…”

Section: Discussionmentioning

confidence: 99%

“…Surprisingly, on the cuticle of T. dendrolimi , more conidia were detected at 96 h post‐treatment than those in the previous observations. Conidia and hyphae are two cell morphologies of entomopathogenic fungi on host surface: conidia are propagules initiating pathogenesis and involved in disease transmission, and hyphae generations are critical to the invasion and virulence of the fungi 52 . A regulatory G protein‐signalling gene, Bbrgs1 , has been found to play an important role in regulating the switch between vegetative growth and conidiation of B. bassiana in response to specific environmental cue 53 .…”

Section: Discussionmentioning

confidence: 99%

Laboratory evaluation of the compatibility of Beauveria bassiana with the egg parasitoid Trichogramma dendrolimi (Hymenoptera: Trichogrammatidae) for joint application against the oriental fruit moth Grapholita molesta (Lepidoptera: Tortricidae)

Fang

Liu

et al. 2022

Pest Management Science

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BACKGROUND The entomopathogenic fungus Beauveria bassiana and the egg parasitoid Trichogramma dendrolimi can both contribute to biological control of the global fruit borer Grapholita molesta. To derive insights for optimizing their combined application in augmentation programs, we assayed fungal pathogenicity to both G. molesta (eggs, larvae and adults) and adult parasitoids, and assessed wasp acquisition and transmission of fungal spores following their emergence from B. bassiana‐treated host eggs. RESULTS Concentrations of 108 conidia mL−1 of B. bassiana and higher caused virtually complete mortality of G. molesta larvae, but less than 30% mortality of eggs, and female moths surviving treatments had reduced fecundity. More than 80% of adult T. dendrolimi survived B. bassiana treatments of 107 conidia mL−1, and more than 60% survived 109 conidia mL−1, with surviving females achieving reproductive success equivalent to controls. Parasitoid females preferred healthy eggs over B. bassiana‐infected ones in choice tests; wasps emerging from treated eggs carried about 104 conidia each and contributed an additional 11% host mortality in trials combining both agents. CONCLUSION Our results indicate that combined applications of B. bassiana and T. dendrolimi can have complimentary impacts on G. molesta, the wasps compensating for low fungal pathogenicity to eggs and their progeny potentially aiding in subsequent disease transmission. Although foraging wasps tended to avoid infected eggs, negative interactions between the two agents might be further mitigated by timing B. bassiana applications from late instar larva to early moth stage, and T. dendrolimi releases several days later to coincide with peak oviposition periods. © 2022 Society of Chemical Industry.

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“…After 3 and 4 days of culture, blastospore production (cell mL −1 ) was recorded. A conidial germination assay was performed to assess the time for 50% conidial germination (GT 50 , h) as a viability index ( 60 ). Additionally, the conidial thermotolerance of the strains at 45°C was measured, and the median lethal time (LT 50 , min) was used as the resistance index.…”

Section: Methodsmentioning

confidence: 99%

Ada2 and Ada3 Regulate Hyphal Growth, Asexual Development, and Pathogenicity in Beauveria bassiana by Maintaining Gcn5 Acetyltransferase Activity

Zheng

et al. 2023

Microbiol Spectr

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BbWor1, a Regulator of Morphological Transition, Is Involved in Conidium-Hypha Switching, Blastospore Propagation, and Virulence in Beauveria bassiana

Cited by 5 publications

References 49 publications

Inhibitory effects of a maleimide compound on the virulence factors of Candida albicans

Inhibitory effects of a maleimide compound on the virulence factors of Candida albicans

Laboratory evaluation of the compatibility of Beauveria bassiana with the egg parasitoid Trichogramma dendrolimi (Hymenoptera: Trichogrammatidae) for joint application against the oriental fruit moth Grapholita molesta (Lepidoptera: Tortricidae)

Ada2 and Ada3 Regulate Hyphal Growth, Asexual Development, and Pathogenicity in Beauveria bassiana by Maintaining Gcn5 Acetyltransferase Activity

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