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Zaretsky, Joseph Z.; Barnea, Itay; Aylon, Yael; Gorivodsky, Marat; Wreschner, Daniel H.; Keydar, Iafa

doi:10.1186/1476-4598-5-57

Cited by 63 publications

(38 citation statements)

References 66 publications

(78 reference statements)

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“…1). In agreement with other reports (29), MCF-7 cells express high MUC1. Interestingly, H2073 and H1793 cells, derived from female patients, also express high MUC1 protein.…”

Section: Resultssupporting

confidence: 93%

“…We did not detect E 2 regulation of MUC1 mRNA in any lung adenocarcinoma cells, HBECs, or MCF-7 cells and conclude that E 2 does not regulate MUC1 in these cells. The difference between our results and those reported earlier in MCF-7 cells (29) is that we used Q-PCR rather than a MUC1-promoter-reporter and non-quantitative PCR. While the samples size is small, we observed no significant difference in MUC1/A and MUC1/B splice variant expression between lung adenocarcinoma cell lines derived from female versus male patients.…”

Section: Discussioncontrasting

confidence: 94%

“…The factors regulating MUC1 expression appear to be cell-type specific. E 2 and tamoxifen increased the secreted MUC1 isoform transcription via ERα activation in breast cancer cells (29), but E 2 did not increase MUC1 in human endometrial cancer cells (42). We did not detect E 2 regulation of MUC1 mRNA in any lung adenocarcinoma cells, HBECs, or MCF-7 cells and conclude that E 2 does not regulate MUC1 in these cells.…”

Section: Discussionmentioning

confidence: 98%

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Targeting the Intracellular MUC1 C-terminal Domain Inhibits Proliferation and Estrogen Receptor Transcriptional Activity in Lung Adenocarcinoma Cells

Klinge

Radde

Imbert-Fernandez

et al. 2011

Molecular Cancer Therapeutics

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Mucin 1 (MUC1) is a diagnostic factor and therapy target in lung adenocarcinoma. MUC1 C-terminal intracellular domain (CD) interacts with estrogen receptor α (ERα) and increases gene transcription in breast cancer cells. Because lung adenocarcinoma cells express functional ERα and estrogen receptor β (ERβ) we examined MUC1 expression and MUC1-ER interaction. Since blocking MUC1 CD with an inhibitory peptide (PMIP) inhibited breast tumor growth, we tested whether PMIP would inhibit lung adenocarcinoma cell proliferation. We report that MUC1 interacts with ERα and ERβ within the nucleus of H1793 lung adenocarcinoma cells in accordance with MUC1 expression. PMIP was taken up by H23 and H1793 cells and inhibited the proliferation of H1793, but not H23 cells, concordant with higher MUC1 in H1793 cells. Lower MUC1 protein in H23 does not correspond to miR-125b and miR-145 that have been reported to reduce MUC1 expression. PMIP had no effect on the viability of normal human bronchial epithelial cells, which lack MUC1 expression. PMIP inhibited estradiol (E2) –activated reporter gene transcription and endogenous cyclin D1 and nuclear respiratory factor-1 (NRF-1) gene transcription in H1793 cells. These results indicate MUC1-ER functional interaction in lung adenocarcinoma cells and that inhibiting MUC1 inhibits lung adenocarcinoma cell viability.

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“…1). In agreement with other reports (29), MCF-7 cells express high MUC1. Interestingly, H2073 and H1793 cells, derived from female patients, also express high MUC1 protein.…”

Section: Resultssupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 94%

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Targeting the Intracellular MUC1 C-terminal Domain Inhibits Proliferation and Estrogen Receptor Transcriptional Activity in Lung Adenocarcinoma Cells

Klinge

Radde

Imbert-Fernandez

et al. 2011

Molecular Cancer Therapeutics

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“…The expression of MUC1 protein was observed in the 282 cytoplasm and along the cell membrane as previously mentioned 283 in literature [25][26][27][28]. Gene expression studies showed that MUC1 284 expression was reduced following treatment with two drug 285 cocktails: the first cocktail (i.e.…”

mentioning

confidence: 64%

The effects of HAART on the expression of MUC1 and P65 in a cervical cancer cell line, HCS-2

Thabethe¹,

Adefolaju²,

Hosie³

2015

Biomedicine & Pharmacotherapy

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“…ACOX2 up-regulation in the tumor conferred the same protective effect on mortality as MUC1 (mucin 1, cell surface associated 1q21). Variants of MUC1 interact with estrogen [30], and higher expression is associated with late stage epithelial ovarian cancer [31, 32] and prostate cancer [33]. …”

Section: Discussionmentioning

confidence: 99%

Race-associated biological differences among Luminal A breast tumors

D’Arcy

Fleming

Robinson

et al. 2015

Breast Cancer Res Treat

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Purpose African American (AA) women have higher breast-cancer specific mortality rates. A higher prevalence of the worse outcome Basal-like breast cancer subtype contributes to this, but AA women also have higher mortality even within the more favorable outcomes Luminal A breast cancers. These differences may reflect treatment or health care access issues, inherent biological differences, or both. Methods To identify potential biological differences by race among Luminal A breast cancers, gene expression data from 108 CAU and 57 AA breast tumors were analyzed. Race-associated genes were next evaluated for associations with survival. Finally, expression of race- and survival-associated genes was evaluated in normal tissue of AA and CAU women. Results Six genes (ACOX2, MUC1, CRYBB2, PSPH, SQLE, TYMS) were differentially expressed by race among Luminal A breast cancers and were associated with survival (HR < 0.8, HR > 1.25). For all six genes, tumors in AA had higher expression of poor prognosis genes (CRYBB2, PSPH, SQLE, TYMS) and lower expression of good prognosis genes (ACOX2, MUC1). A score based on all six genes predicted survival in a large independent dataset (HR = 1.9 top vs. bottom quartile, 95% CI: 1.4 – 2.5). For four genes, normal tissue of AA and CAU women showed similar expression (ACOX2, MUC1, SQLE, TYMS), however, the poor outcome associated genes CRYBB2 and PSPH were more highly expressed in AA vs. CAU women’s normal tissue. Conclusions This analysis identified gene expression differences that may contribute to mortality disparities and suggests that among Luminal A breast tumors there are biological differences between AA and CAU patients. Some of these differences (CRYBB2 and PSPH) may exist from the earliest stages of tumor development, or even precede malignancy.

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Cited by 63 publications

References 66 publications

Targeting the Intracellular MUC1 C-terminal Domain Inhibits Proliferation and Estrogen Receptor Transcriptional Activity in Lung Adenocarcinoma Cells

Targeting the Intracellular MUC1 C-terminal Domain Inhibits Proliferation and Estrogen Receptor Transcriptional Activity in Lung Adenocarcinoma Cells

The effects of HAART on the expression of MUC1 and P65 in a cervical cancer cell line, HCS-2

Race-associated biological differences among Luminal A breast tumors

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