"BBAT has made me realise, that it is not only my thoughts that represent me"

Faria, Liliana; Skjærven, Liv Helvik

doi:10.1037/e573112012-068

Cited by 1 publication

(2 citation statements)

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“…Thus, LCIA will likely need to evolve beyond in vivo toxicity data if it is to be applicable for decision support involving new and emerging chemicals. (38) The U.S. National Research Council (NRC) (88) has recommended a transition from in vivo animal testing to in vitro assays (89,90) to address toxicity gaps on the large numbers of chemicals in commerce. For example, data generated under the Tox21 program (a collaboration between the U.S. National Institutes of Health and U.S. EPA) have resulted in information on the bioactivity of thousands of substances.…”

Section: Effectsmentioning

confidence: 99%

“…Instead, in vitro toxicity concentrations can be linked to doses using dosimetry modeling to forward-calculate a resulting blood or target tissue concentration from a given exposure. (89,92) Alternatively, reverse dosimetry can be used to convert a target tissue concentration to an equivalent absorbed dose, which can then be compared with an estimated exposure. (31,55,(93)(94)(95) Other sources of toxicity data include computational (or in silico) models,(96) which do not necessarily require the use of dosimetry modeling and instead may be designed to predict effects based on exposures or absorbed doses.…”

Section: Effectsmentioning

confidence: 99%

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Conceptual Framework To Extend Life Cycle Assessment Using Near-Field Human Exposure Modeling and High-Throughput Tools for Chemicals

Csiszar

Meyer

Dionisio

et al. 2016

Environ. Sci. Technol.

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Life Cycle Assessment (LCA) is a decision-making tool that accounts for multiple impacts across the life cycle of a product or service. This paper presents a conceptual framework to integrate human health impact assessment with risk screening approaches to extend LCA to include near-field chemical sources (e.g., those originating from consumer products and building materials) that have traditionally been excluded from LCA. A new generation of rapid human exposure modeling and high-throughput toxicity testing is transforming chemical risk prioritization and provides an opportunity for integration of screening-level risk assessment (RA) with LCA. The combined LCA and RA approach considers environmental impacts of products alongside risks to human health, which is consistent with regulatory frameworks addressing RA within a sustainability mindset. A case study is presented to juxtapose LCA and risk screening approaches for a chemical used in a consumer product. The case study demonstrates how these new risk screening tools can be used to inform toxicity impact estimates in LCA and highlights needs for future research. The framework provides a basis for developing tools and methods to support decision making on the use of chemicals in products.

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Section: Effectsmentioning

confidence: 99%