Bayesian network meta-analysis suggests a similar effectiveness between a monovalent and a pentavalent rotavirus vaccine

Takeuchi, Masato

doi:10.4161/hv.28284

Cited by 8 publications

(3 citation statements)

References 19 publications

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“…There are other vaccine-preventable diseases for which the RCTs and other studies were conducted more similarly to one another, allowing for NMA to synthesize the comparable efficacy or effectiveness. 15,16 While use of an NMA to evaluate the comparative efficacy or effectiveness of PCV-13 and PHiD-CV would allow for a relatively simple statistical analysis of existing data to address an important data gap, the current evidence base is insufficient to conduct and NMA. In the absence of head-to-head studies, public health decision-makers evaluating PCVs will need to rely on real-world evidence such as the reviews conducted by the WHO Strategic Advisory Group of Experts on Immunization 1 and the Comité sur l'immunisation du Québec (CIQ), 44 together with cost considerations.…”

Section: Discussionmentioning

confidence: 99%

“…14 More recently in vaccines, NACI commissioned an NMA in order to assess relative efficacy, effectiveness and safety of vaccines for herpes zoster, 15 and an NMA has been used to evaluate the comparative effectiveness of two rotavirus vaccines. 16 Given the complexity of the pediatric pneumococcal disease literature and the evolving landscape of new vaccine preparations, the use of NMA methodology to compare vaccines is a logical next step. The objective of this feasibility study was to assess whether NMA methodology could be used to evaluate the comparative efficacy or effectiveness of PHiD-CV and PCV-13 in preventing IPD in children aged <5 years, using RCTs and observational studies.…”

Section: Introductionmentioning

confidence: 99%

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A systematic literature review and network meta-analysis feasibility study to assess the comparative efficacy and comparative effectiveness of pneumococcal conjugate vaccines

McGirr

Iqbal

Izurieta

et al. 2019

Human Vaccines & Immunotherapeutics

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Background: No head-to-head studies are currently available comparing pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) with 13-valent pneumococcal conjugate vaccine (PCV-13). This study explored the feasibility of using network meta-analysis (NMA) to conduct an indirect comparison of the relative efficacy or effectiveness of the two vaccines.Methods: A systematic literature search was conducted for published randomized controlled trials (RCTs) and non-RCT studies reporting data on vaccine efficacy or effectiveness against invasive pneumococcal disease in children aged <5 years receiving 7-valent pneumococcal conjugate vaccine (PCV-7), PHiD-CV or PCV-13. Study quality was evaluated using published scales. NMA feasibility was assessed by considering whether a connected network could be constructed by examining published studies for differences in study or patient characteristics that could act as potential treatment effect modifiers or confounding variables.Results: A total of 26 publications were included; 2 RCTs (4 publications), 7 indirect cohort studies, and 14 case-control studies (15 publications). Study quality was generally good. The RCTs could not be connected in a network as there was no common comparator. The studies differed considerably in design, dose number, administration schedules, and subgroups analyzed. Reporting of exposure status and subject characteristics was inconsistent.Conclusion: NMA to compare the relative efficacy or effectiveness of PHiD-CV and PCV-13 is not feasible on the current evidence base, due to the absence of a connected network across the two RCTs and major heterogeneity between studies. NMA may be possible in future if sufficient RCTs become available to construct a connected network.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A systematic literature review and network meta-analysis feasibility study to assess the comparative efficacy and comparative effectiveness of pneumococcal conjugate vaccines

McGirr

Iqbal

Izurieta

et al. 2019

Human Vaccines & Immunotherapeutics

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“…The statistical analyses will be performed by one author (MT) on the basis of previous expertise. 50 …”

Section: Methods and Analysismentioning

confidence: 99%

Comparative effectiveness of inhaled corticosteroids for paediatric asthma: protocol for a systematic review and Bayesian network meta-analysis

et al. 2015

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IntroductionUse of inhaled corticosteroid (ICS) is the mainstream maintenance therapy for paediatric asthma. Several forms of ICS are available, but the relative effectiveness among ICS has not been well investigated in published, randomised, controlled trials. The paucity of direct comparisons between ICS may have resulted in insufficient estimation in former systematic reviews/meta-analyses. To supplement the information on the comparative effectiveness of ICS for paediatric asthma, we plan to conduct a network meta-analysis that will enable summary of direct and indirect evidence.Methods and analysisWe will retrieve randomised, controlled trials that examined the effectiveness of ICS for paediatric asthma from the PubMed and Cochrane Central Register of Controlled Trials. After one author scans the title and abstract for eligible studies, two authors will independently review study data and assess the quality of the study. Studies of children (≤18 years old) with chronic asthma or recurrent wheezing episodes will be included if they used ICS for ≥4 weeks. We will define a priori core outcomes and supplemental outcomes of paediatric asthma, including exacerbation, healthcare use and pulmonary function. Studies reporting a minimum of one core outcome will be entered into the systematic review. After the systematic review is performed, extracted data of relevant studies will be synthesised in the Bayesian framework using a random-effects model.Ethics and disseminationThe results will be disseminated through peer-reviewed publications and conference presentations.Protocol registration numberUMIN (000016724) and PROSPERO (CRD42015025889).

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Recommendations for vaccination against ROTAvirus in PREMature newborns (ROTAPREM)

Aldeán

Segura

González

et al. 2019

Anales de Pediatría (English Edition)

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Bayesian network meta-analysis suggests a similar effectiveness between a monovalent and a pentavalent rotavirus vaccine

Cited by 8 publications

References 19 publications

A systematic literature review and network meta-analysis feasibility study to assess the comparative efficacy and comparative effectiveness of pneumococcal conjugate vaccines

A systematic literature review and network meta-analysis feasibility study to assess the comparative efficacy and comparative effectiveness of pneumococcal conjugate vaccines

Comparative effectiveness of inhaled corticosteroids for paediatric asthma: protocol for a systematic review and Bayesian network meta-analysis

Recommendations for vaccination against ROTAvirus in PREMature newborns (ROTAPREM)

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