Bayesian Methods for Evidence Evaluation

Goodman, Steven N.

doi:10.1161/circulationaha.113.003193

Cited by 4 publications

(1 citation statement)

References 12 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such an approach would assign less weight to study design types that are more susceptible to bias (e.g., observational designs) relative to RCT designs. Empirically, these weights might be developed via meta-regression examining how effect estimates vary by study design, as has been suggested previously [ 21 ]. Additionally, expert judgments may be elicited via survey or using a Delphi or group consensus approach, where this information may be quantified in the form of a prior probability distribution.…”

Section: Discussionmentioning

confidence: 99%

Meta-Analysis of Sulfonylurea Therapy on Long-Term Risk of Mortality and Cardiovascular Events Compared to Other Oral Glucose-Lowering Treatments

2018

View full text Add to dashboard Cite

IntroductionAmong the most pressing clinical decisions in type 2 diabetes treatments are which drugs should be used after metformin is no longer sufficient, and whether sulfonylureas (SUs) should remain as a suitable second-line treatment. In this article we summarize current evidence on the long-term safety risks associated with SU therapy relative to other oral glucose-lowering therapies.MethodsThe MEDLINE database and Clinicaltrials.gov were searched for observational and experimental studies comparing the safety of SUs to that of other diabetes medications in people with type 2 diabetes mellitus through December 15, 2015. Studies with at least 1 year of follow-up, which explicitly examined major cardiovascular events or death in patients who showed no evidence of serious conditions at baseline, were selected for inclusion in meta-analyses.ResultsSU treatment was associated with an elevated risk relative to treatment with metformin (METF), thiazolidinedione (TZD), dipeptidyl peptidase-4 inhibitor (DPP-4), and glucagon-like peptide-1 (GLP-1) agonist classes, either when compared alone (as a monotherapy) or when used in combination with METF. Significant findings were almost entirely derived from nontrial data and not confirmed by smaller, efficacy designed randomized controlled trials whose effects were in the same direction but much more imprecise.ConclusionAlthough much of the evidence is derived and will continue to come from observational studies, the methodological rigor of such studies is questionable. A key challenge for evaluators is the extent to which they should incorporate evidence from study designs that are quasi-experimental.Electronic supplementary materialThe online version of this article (10.1007/s13300-018-0443-z) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Meta-Analysis of Sulfonylurea Therapy on Long-Term Risk of Mortality and Cardiovascular Events Compared to Other Oral Glucose-Lowering Treatments

2018

View full text Add to dashboard Cite

show abstract

Heart failure treatment — clinical trials versus clinical practice

Cohn

2016

Nat Rev Cardiol

View full text Add to dashboard Cite

Evidence-based decision support for the clinical practice of acupuncture: Data mining approaches

Meng

Zhang

Zeng

et al. 2013

2013 IEEE International Conference on Bioinformatics and Biomedicine

View full text Add to dashboard Cite

the concept and methodology of evidence-based medicine (EBM) and the strategy to promote efficacy of acupuncture in clinical practice are introduced in this paper. Then it focuses on using the data mining approaches to integrate the primary evidence from real practice based on conventional clinical data and secondary evidence by systematic literature review or Meta-analysis. The new analytic method is capable of explore in-depth on the latent rules and relations of acupuncture and Chinese medicine versus the effectiveness in real practice. A data warehouse is recommended to be set up to store and manage the above evidence processed by appropriate data mining algorithms and models. As the data from different origins is hopefully to be integrated in a clinical decision support system, it will be able to provide evidence-based references and recommendations for the clinical practice of acupuncture and Chinese medicine.

show abstract

Bayesian Methods for Evidence Evaluation

Cited by 4 publications

References 12 publications

Meta-Analysis of Sulfonylurea Therapy on Long-Term Risk of Mortality and Cardiovascular Events Compared to Other Oral Glucose-Lowering Treatments

Meta-Analysis of Sulfonylurea Therapy on Long-Term Risk of Mortality and Cardiovascular Events Compared to Other Oral Glucose-Lowering Treatments

Heart failure treatment — clinical trials versus clinical practice

Evidence-based decision support for the clinical practice of acupuncture: Data mining approaches

Contact Info

Product

Resources

About