Bayesian methods for chromosome dosimetry following a criticality accident

Abstract

Radiation doses received during a criticality accident will be from a combination of fission spectrum neutrons and gamma rays. It is desirable to estimate the total dose, as well as the neutron and gamma doses. Present methods for dose estimation with chromosome aberrations after a criticality accident use point estimates of the neutron to gamma dose ratio obtained from personnel dosemeters and/or accident reconstruction calculations. In this paper a Bayesian approach to dose estimation with chromosome aberrations is developed which allows the uncertainty of the dose ratio to be considered. Posterior probability densities for the total and the neutron and gamma doses were derived.

Analytical and quasi-Bayesian methods as development of the iterative approach for mixed radiation biodosimetry

“…9 ), which corresponds to the contribution of the gamma dose to the total dose and is more practical in use than ρ . It is normalized to the range of [0, 1] and is defined as (Brame and Groer 2003 ): …”

“…Dose estimation using biodosimetry methods for a mixed neutron and gamma radiation field can be found in the literature (IAEA 2011; Brame and Groer 2003; Szłuińska et al 2005; Fornalski 2014). The most common approaches are the classical iterative method, promoted widely by the International Atomic Energy Agency (IAEA 2011), and the increasingly used Bayesian methods (Brame and Groer 2003; Ainsbury et al 2013a, b; Pacyniak et al 2014).…”

“…The most common approaches are the classical iterative method, promoted widely by the International Atomic Energy Agency (IAEA 2011), and the increasingly used Bayesian methods (Brame and Groer 2003; Ainsbury et al 2013a, b; Pacyniak et al 2014). The iterative method is adopted in many accredited laboratories worldwide, including the Central Laboratory for Radiological Protection (CLOR), Poland.…”

The Monte Carlo Method of Mixed Radiation Field Dose Assessment in the Cytogenetic Biodosimetry

“…An example of that informative prior is the Gaussian distribution for ρ however in practical applications, the scaled Gaussian distribution in θ coordinates (see Eq. (2)) is preferred [13]:…”

Applications of Fluorescence in Situ Hybridization in Radiation Cytogenetic Biodosimetry and Population Monitoring

“…Mixed beam exposure can also complicate the interpretation of the dose estimated by DCA if information is lacking on physical determination of dose ratio between the two radiation qualities. In the absence of ratio estimate, a Bayesian approach can be used as described by Brame and Groer [27]. Another limiting factor is the decline of dicentric chromosomes over time and therefore DCA needs to be performed within a reasonable amount of time (~ 4 weeks) after exposure.…”