Bayesian Hierarchical Modeling with Markov Chain Monte Carlo Methods

Duffull, Stephen B.; Friberg, Lena E.; Dansirikul, C.

doi:10.1002/9780470087978.ch5

Cited by 8 publications

(10 citation statements)

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“…Briefly, the conventional 1‐, 2‐ and 3‐compartment models were estimated using NONMEM VII (ICON Development Solution, Ellicott City, MD, USA). The best pharmacokinetic model, which was the final model, had the minimum values of Bayesian Information Criterion (BIC) among all the evaluated models (Duffull et al. , 2007).…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the predictive performance of a pharmacokinetic model for propofol in Japanese macaques (Macaca fuscata fuscata)

Miyabe‐Nishiwaki

Masui

Kaneko

et al. 2012

Vet Pharm & Therapeutics

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Propofol is a short-acting intravenous anesthetic used for induction/maintenance anesthesia. The objective of this study was to assess a population pharmacokinetic (PPK) model for Japanese macaques during a step-down infusion of propofol. Five male Japanese macaques were immobilized with ketamine (10 mg/kg) and atropine (0.02 mg/kg). A bolus dose of propofol (5 mg/kg) was administrated intravenously (360 mg/kg/h) followed by step-down infusion at 40 mg/kg/h for 10 min, 20 mg/kg/h for 10 min, and then 15 mg/kg/h for 100 min. Venous blood samples were repeatedly collected following the administration. The plasma concentration of propofol (Cp) was measured by high-speed LC-FL. PPK analyses were performed using NONMEM VII. Median absolute prediction error and median prediction error (MDPE), the indices of prediction inaccuracy and bias, respectively, were calculated, and PE - individual MDPE vs. time was depicted to show the variability of prediction errors. In addition, we developed another population pharmacokinetic model using previous and current datasets. The previous PK model achieved stable prediction of propofol Cp throughout the study period, although it underestimates Cp. The step-down infusion regimen described in this study would be feasible in macaques during noninvasive procedures.

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Section: Methodsmentioning

confidence: 99%

Evaluation of the predictive performance of a pharmacokinetic model for propofol in Japanese macaques (Macaca fuscata fuscata)

Miyabe‐Nishiwaki

Masui

Kaneko

et al. 2012

Vet Pharm & Therapeutics

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show abstract

“…The Bayesian Information Criterion value was used to select the best structural model because the Bayesian Information Criterion would provide a more appropriate selection than the OFV when the different structural models are compared. 14…”

Section: Population Pharmacokinetic Modelingmentioning

confidence: 99%

Early Phase Pharmacokinetics but Not Pharmacodynamics Are Influenced by Propofol Infusion Rate

et al. 2009

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This study found that a combined pharmacokinetic-dynamic model consisting of a two-compartmental model with a LAG time and presystemic compartments and a sigmoidal maximum possible drug effect model accurately described the early phase pharmacology of propofol during infusion rate between 10 and 160 mg . kg(-1). h(-1). The infusion rate has an influence on kinetics, but not dynamics. Age was a covariate for LAG time.

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“…Residual intraindividual variability was modelled using constant coefficient of variance model. The best pharmacokinetic model, which was the final model, had the minimum values of Bayesian Information Criterion (BIC) among all the evaluated models (Duffull et al. 2007).…”

mentioning

confidence: 99%

Hypnotic effects and pharmacokinetics of a single bolus dose of propofol in Japanese macaques (Macaca fsucata fsucata)

Miyabe‐Nishiwaki

Masui

Kaneko

et al. 2010

Veterinary Anaesthesia and Analgesia

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Bayesian Hierarchical Modeling with Markov Chain Monte Carlo Methods

Cited by 8 publications

References 0 publications

Evaluation of the predictive performance of a pharmacokinetic model for propofol in Japanese macaques (Macaca fuscata fuscata)

Evaluation of the predictive performance of a pharmacokinetic model for propofol in Japanese macaques (Macaca fuscata fuscata)

Early Phase Pharmacokinetics but Not Pharmacodynamics Are Influenced by Propofol Infusion Rate

Hypnotic effects and pharmacokinetics of a single bolus dose of propofol in Japanese macaques (Macaca fsucata fsucata)

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