Bayesian evaluation of temporal changes in sensitivity and specificity of three serological tests for multiple circulating strains of rabbit haemorrhagic disease virus
Abstract:Competition and indirect ELISAs are currently being used to monitor
rabbit hemorrhagic disease viruses (RHDV1 and RHDV2) in rabbits
worldwide. Temporal changes in the sensitivity (Se) and specificity (Sp)
of assays were investigated using Bayesian Latent Class models (BCLM) in
the Australian wild rabbit population where both viruses circulate
simultaneously and a long-term serological dataset exists. When cELISA1
was compared to IgG1 ELISA, the Se of cELISA1 improved while the Sp of
IgG1 ELISA declined over th… Show more
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