“…To date, several (patho)physiological factors are reported to account for PK variability of AMK in ICU patients with sepsis: body weight, oxygen extraction ratio, serum albumin, and sepsis severity (estimated by the Acute Physiology And Chronic Health Evaluation [APACHE] II score) for the Vd variability, creatinine clearance, positive end-expiratory pressure, and catecholamine administration for the CL variability. [11][12][13][14][15] Among PK-based dosing methods dedicated to the aminoglycoside TDM, the Bayesian maximum a posteriori approach appears attractive for ICU patients. Unlike nonBayesian methods (eg, nomogram, non-Bayesian least-squares method), the maximum a posteriori estimation displays better predictive performance for individualized drug dosage, because it incorporates some prior information (ie, covariates, PK model, residual error model, prior distributions).…”