2010
DOI: 10.1007/s10985-010-9181-x
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Bayesian analysis for monotone hazard ratio

Abstract: We propose a Bayesian approach for estimating the hazard functions under the constraint of a monotone hazard ratio. We construct a model for the monotone hazard ratio utilizing the Cox's proportional hazards model with a monotone time-dependent coefficient. To reduce computational complexity, we use a signed gamma process prior for the time-dependent coefficient and the Bayesian bootstrap prior for the baseline hazard function. We develop an efficient MCMC algorithm and illustrate the proposed method on simula… Show more

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Cited by 8 publications
(9 citation statements)
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“…See, for example, Dimatteo et al (2001), Hennerfeind (2006), Sharef et al (2010), Xing et al (2012) and Nasri et al (2013). In addition, a prior based on a Gamma process is devised for monotonically increasing time-varying coefficients, which have been frequently used as an alternative to constant coefficients (Gill & Schumacher, 1987;Deshpande & Sengupta, 1995;Kim et al, 2011). Moreover, monotonically increasing time-varying coefficients are used to assess the existence of waning of treatment effect (Durham et al, 1998).…”
Section: Introductionmentioning
confidence: 99%
“…See, for example, Dimatteo et al (2001), Hennerfeind (2006), Sharef et al (2010), Xing et al (2012) and Nasri et al (2013). In addition, a prior based on a Gamma process is devised for monotonically increasing time-varying coefficients, which have been frequently used as an alternative to constant coefficients (Gill & Schumacher, 1987;Deshpande & Sengupta, 1995;Kim et al, 2011). Moreover, monotonically increasing time-varying coefficients are used to assess the existence of waning of treatment effect (Durham et al, 1998).…”
Section: Introductionmentioning
confidence: 99%
“…In this study, we follow the common practice to select d jk , j = 1, … , G − 1 as the jGth percentile of X ik and conduct sensitivity analysis by disturbing G from 5 to 10. Kim et al 29 and others also considered alternative approaches, such as the Bayesian Bootstrap prior, for modeling the baseline hazard function.…”
Section: Bayesian Inferencementioning
confidence: 99%
“…Details of the Bayesian bootstrap and applications can be found in Kim and Lee ( 2003 ) and Kim et al. ( 2011 ). After obtaining the posterior samples, we calculated the Bayes estimates of If the estimates are over 0.5, we reject equivalence of hazard functions, i.e., we choose a model with higher posterior probability.…”
Section: Partial Likelihood Priors and Posteriors For The Testmentioning
confidence: 99%
“…Although Kalbfleisch ( 1978 ), Hjort ( 1990 ), and Kim ( 2006 ) turned to the Bayesian methodology for estimation of hazard or survival function and Kim et al. ( 2011 ) proposed the Bayesian test for monotone hazards, to our best knowledge, there are only a few studies done for testing equivalence of hazards including crossing hazards.…”
Section: Introductionmentioning
confidence: 99%