Biochemical Pharmacology volume 79, issue 11, P1589-1599 2010 DOI: 10.1016/j.bcp.2010.01.032 View full text
Bhavya Balan Chandrika, Sathish Kumar Maney, Swathi U. Lekshmi, Jeena Joseph, Mahendra Seervi, Praveen K.S., Santhoshkumar T.R.

Abstract: Tumors often acquire drug resistance due to functional loss of pro apoptotic gene Bax, a critical and essential component of cell death rendering them insensitive to most anti-tumor agents. Compounds that can induce Bax independent apoptotic cell death are expected to overcome such drug resistance. We have employed a live cell based screening platform to identify potential compounds that can induce programmed cell death in Bax deficiency. Release of cytochrome C from mitochondria into the cytosol is a decisive…

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