Bawei Chenxiang Wan Ameliorates Cardiac Hypertrophy by Activating AMPK/PPAR-α Signaling Pathway Improving Energy Metabolism

Zhang, Xiaoying; Zhang, Zhiying; Wang, Pengxiang; Han, Yijie; Liu, Lijun; Li, Jie; Chen, Yi‐Chun; Liu, Duxia; Wang, Jinying; Tian, Xiaoying; Zhao, Qin; Yan, F.

doi:10.3389/fphar.2021.653901

Cited by 9 publications

(11 citation statements)

References 46 publications

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“…It has been proved that PPAR-α activation during the pressure overloaded HF induction can improve cardiac function and energy. In addition, PPAR-α also participates in the signaling cascades driven by AMPK [ 28 , 33 , 34 ]. In accordance with previous studies, PPAR-α, PGC-1α, CD36, CPT-1, and ACADM levels were decreased in the HF group, compared to that in the sham control group.…”

Section: Discussionmentioning

confidence: 99%

Cardiac contractility modulation ameliorates myocardial metabolic remodeling in a rabbit model of chronic heart failure through activation of AMPK and PPAR-α pathway

et al. 2022

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Metabolic remodeling contributes to the pathological process of heart failure (HF). We explored the effects of cardiac contractility modulation (CCM) on myocardial metabolic remodeling in the rabbit model with HF. The HF in rabbit model was established by pressure uploading and then CCM was applied. We evaluated the cardiac structure and function by echocardiography, serum BNP level, and hematoxylin and eosin and Masson’s trichrome staining. We detected the accumulation of glycogen and lipid droplets in myocardial tissues by periodic acid-Schiff and Oil Red O staining. Then, we measured the contents of glucose, free fatty acid (FFA), lactic acid, pyruvate, and adenosine triphosphate (ATP) levels in myocardial tissues by corresponding kits and the expression levels of key factors related to myocardial substrate uptake and utilization by western blotting were analyzed. CCM significantly restored the cardiac structure and function in the rabbit model with HF. CCM therapy further decreased the accumulation of glycogen and lipid droplets. Furthermore, CCM reduced the contents of FFA, glucose, and lactic acid, and increased pyruvate and ATP levels in HF tissues. The protein expression levels related to myocardial substrate uptake and utilization were markedly improved with CCM treatment by further activating adenosine monophosphate-activated protein kinase and peroxisome proliferator-activated receptor-α signaling pathways.

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Section: Discussionmentioning

confidence: 99%

Cardiac contractility modulation ameliorates myocardial metabolic remodeling in a rabbit model of chronic heart failure through activation of AMPK and PPAR-α pathway

et al. 2022

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“…Ensuring the blood supply recovery of the ischemic myocardial tissue is an important goal in the efforts to prevent or alleviate MI/RI. As an essential component of traditional Chinese medicines, TTMs have advantages in terms of their efficacy and fewer side effects due to their many targets, which make them unique in the treatment of cardiovascular disease [ 22 , 23 ]. In our previous study, we found that O. falcata extract demonstrated significant protective effects against MIRI, but the underlying mechanism is not clear.…”

Section: Discussionmentioning

confidence: 99%

7-Hydroxyflavone Alleviates Myocardial Ischemia/Reperfusion Injury in Rats by Regulating Inflammation

et al. 2022

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Inflammation is the primary pathological process of myocardial ischemia/reperfusion injury (MI/RI). 7-Hydroxyflavone (HF), a natural flavonoid with a variety of bioactivities, plays a crucial role in various biological processes. However, its cardioprotective effects and the underlying mechanisms of MI/RI have not been investigated. This study aimed to explore whether pretreatment with HF could attenuate MI/RI-induced inflammation in rats and investigate its potential mechanisms. The results showed that pretreatment with HF could significantly improve the anatomic data and electrocardiograph parameters, reduce the myocardial infarct size, decrease markers of myocardial injury (aspartate transaminase, creatine kinase, lactate dehydrogenase, and cardiac troponin I), inhibit inflammatory cytokines (IL-1β, IL-6, and TNF-α), suppress oxidative stress, and recover the architecture of the cardiomyocytes. The cardioprotective effect of HF was connected with the regulation of the MAPK/NF-κB signaling pathway. What is more, molecular docking was carried out to prove that HF could be stably combined with p38, ERK1/2, JNK, and NF-κB. In summary, this is a novel study demonstrating the cardioprotective effects of HF against MI/RI in vivo. Consequently, these results demonstrate that HF can be considered a promising potential therapy for MI/RI.

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“…A study has proved that BCW inhibits cardiac hypertrophy by increasing the expression of CPT-1b, P-AMPK, AMPK, and PPAR-α proteins in ISO-induced cardiac hypertrophy rats. The results indicated the anti-cardiac hypertrophy effects of BCW were linked to the amelioration of disturbance in fatty acid metabolism (Zhang et al, 2021). Shensong Yangxin Capsule (SSYX) is a traditional Chinese medicine which has long been used in China to treat cardiac diseases.…”

Section: Cardiac Hypertrophymentioning

confidence: 99%

Fatty acid metabolism disorders and potential therapeutic traditional Chinese medicines in cardiovascular diseases

Liu

Zhang

et al. 2023

Phytotherapy Research

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Cardiovascular diseases are currently the primary cause of mortality in the whole world. Growing evidence indicated that the disturbances in cardiac fatty acid metabolism are crucial contributors in the development of cardiovascular diseases. The abnormal cardiac fatty acid metabolism usually leads to energy deficit, oxidative stress, excessive apoptosis, and inflammation. Targeting fatty acid metabolism has been regarded as a novel approach to the treatment of cardiovascular diseases. However, there are currently no specific drugs that regulate fatty acid metabolism to treat cardiovascular diseases. Many traditional Chinese medicines have been widely used to treat cardiovascular diseases in clinics. And modern studies have shown that they exert a cardioprotective effect by regulating the expression of key proteins involved in fatty acid metabolism, such as peroxisome proliferator‐activated receptor α and carnitine palmitoyl transferase 1. Hence, we systematically reviewed the relationship between fatty acid metabolism disorders and four types of cardiovascular diseases including heart failure, coronary artery disease, cardiac hypertrophy, and diabetic cardiomyopathy. In addition, 18 extracts and eight monomer components from traditional Chinese medicines showed cardioprotective effects by restoring cardiac fatty acid metabolism. This work aims to provide a reference for the finding of novel cardioprotective agents targeting fatty acid metabolism.

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Bawei Chenxiang Wan Ameliorates Cardiac Hypertrophy by Activating AMPK/PPAR-α Signaling Pathway Improving Energy Metabolism

Cited by 9 publications

References 46 publications

Cardiac contractility modulation ameliorates myocardial metabolic remodeling in a rabbit model of chronic heart failure through activation of AMPK and PPAR-α pathway

Cardiac contractility modulation ameliorates myocardial metabolic remodeling in a rabbit model of chronic heart failure through activation of AMPK and PPAR-α pathway

7-Hydroxyflavone Alleviates Myocardial Ischemia/Reperfusion Injury in Rats by Regulating Inflammation

Fatty acid metabolism disorders and potential therapeutic traditional Chinese medicines in cardiovascular diseases

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