Batzella, Crambe and Monanchora: Highly Prolific Marine Sponge Genera Yielding Compounds with Potential Applications for Cancer and Other Therapeutic Areas

Abstract

Pyrroloquinoline and guanidine-derived alkaloids present distinct groups of marine secondary metabolites with structural diversity that displayed potentialities in biological research. A considerable number of these molecular architectures had been recorded from marine sponges belonging to different marine genera, including Batzella, Crambe, Monanchora, Clathria, Ptilocaulis and New Caledonian starfishes Fromia monilis and Celerina heffernani. In this review, we aim to comprehensively cover the chemodiversity and the bioactivities landmarks centered around the chemical constituents exclusively isolated from these three marine genera including Batzella, Crambe and Monanchora over the period 1981–2017, paying a special attention to the polycyclic guanidinic compounds and their proposed biomimetic landmarks. It is concluded that these marine sponge genera represent a rich source of novel compounds with potential applications for cancer and other therapeutic areas.

Long-term experimental in situ farming of Crambe crambe (Demospongiae: Poecilosclerida)

“…Farming C. crambe as a source of bioactive compounds will probably support the supply of marine pharmaceuticals ( Mayer et al, 2017 ) with potential applications for the therapy of cancer and other diseases ( El-Demerdash et al, 2018 ). Moreover, it has a low environmental impact and increases ecosystem services without affecting wild populations ( Pronzato & Manconi, 2008 ).…”

Chemistry and Biological Activities of the Marine Sponges of the Genera Mycale (Arenochalina), Biemna and Clathria

“…Crambescidins, batzelladines, mirabilins and ptilocaulins are definite groups of marine cyclic guanidine-containing alkaloids that display potent biological activities, such as cytotoxic, antiviral, antifungal and anti-HIV-1 gp 120-human. These compounds were isolated from various marine sponge genera, like Batzella , Crambe , Monanchora and Ptilocaulis , and are chemotaxonomic markers for the marine sponges belonging to the orders Poecilosclerida and Axinellida [ 22 , 27 ]. Crambescidin 800 ( 1 ), a pentacyclic guanidine alkaloid, was isolated from the marine sponge Clathria ( Thalysias ) cervicornis , and was found to display potent antimicrobial activity against Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa , with MIC values of 2, 1 and 1 μg/mL, respectively [ 21 ].…”

“…They are rich producers of diverse and physiologically active secondary metabolites [ 12 , 13 ] with a wide range of biological activities, including cytotoxic, antimalarial [ 14 , 15 ], anti-HIV [ 16 ], anti-inflammatory [ 17 , 18 ], enzyme inhibitors [ 19 ], antifungal and antibacterial properties [ 20 , 21 ]. Some of these compounds are chemotaxonomic markers, particularly for some Poecilosclerida marine sponges of the genera Batzella , Crambe and Monanchora [ 22 ]. The World Porifera Database [ 23 ] lists 14 valid species of Mycale ( Arenochalina ), 55 of Biemna, and 381 of Clathria .…”

“…sp., C. calla, C. reinwardtii, C. lissosclera, C. basilana, C. strepsitoxa and C. pyramida were chemically investigated ( Table 1 ). Due to our interest in the marine sponges of the order Poecilosclerida [ 22 , 24 , 25 , 26 ], we have reviewed the literature reporting the isolation of secondary metabolites from these three marine sponge genera, covering the period of 1976–2018. This up-to-date review focuses mainly on the chemistry of the isolated metabolites, although their biological and pharmacological properties are also discussed when they are available.…”

Recent Advances on Marine Alkaloids from Sponges

“…[8] In 2018, El-Demerdash and co-workers summarized chemical structures and biological activities of 147 pyrroloquinoline and guanidine-derived alkaloids from genus of Batzella, Crambe and Monanchora in 1981 -2017. [9] However, these preceding reviews are merely limited to single or few sponge genus and one or two kinds of alkaloids. In this article, we reviewed comprehensively structural features and bioactivities of alkaloids from various sponge genus from 2015 to 2020, aiming at providing more useful information toward clinical utilization of sponge-derived alkaloids with high efficiency and to serve as an update reference for researchers.…”